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Health

Women’s Underrepresentation in Retracted Medical Research

by Dr. Michael Lee – Health Editor November 20, 2025
written by Dr. Michael Lee – Health Editor

Women Authors Considerably Underrepresented in Retracted medical Research

GENEVA, Switzerland – A new study reveals ‌a⁤ striking disparity in retractions within medical research: women’s names appear⁤ on just 23% of ​author ‍slots in nearly 900 retracted articles published ⁢between 2008 and 2017. The research,‌ published November 19 in PLoS ONE, suggests women may be less frequently associated with research leading to retraction, but the⁢ reasons remain complex.

The‍ study, led by Paul Sebo,⁣ an internal medicine specialist and researcher at the University of Geneva, utilized an artificial intelligence tool to⁤ infer author gender based on first names. Findings showed women​ held 16.5% of first-author positions and 12.7% of last-author positions on retracted papers. This contrasts sharply⁢ with ‍a previous⁤ analysis of all articles from the same journals ⁤and ⁣timeframe, which found‌ women represented⁢ 41-45% of first authors and 26-33% of last ​authors.1

“this​ is a really interesting, creative⁤ and robust study,” says Curt Rice, who promotes publishing literacy at the Publishing Unlocked project in Oslo, Norway. “The article invites us to dig into issues like negotiations about authorship and the⁢ likelihood of scrutiny.”

While acknowledging the limitations ⁤of gender-prediction ‍tools – including thier inability to ⁢account for non-binary identities and potential inaccuracies with non-Western names ‍- Sebo conducted ⁣a manual check of 200 names and found no discrepancies.

In an email ​to Nature, Sebo theorized the disparity may ⁤be linked to women’s underrepresentation in⁣ senior academic roles and leadership of research projects.‌ He suggests this could result in women being less⁣ exposed to the “kinds of responsibilities (and risks) that are ​more commonly associated with retractions.”

The findings add‍ to existing data showing women are⁤ generally under-represented⁤ in medical research.2

1 ⁤ Sebo, P. et al. PLoS ONE (2023).
2 nature. ⁢https://www.nature.com/articles/d43978-021-00132-4

November 20, 2025 0 comments
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Health

Obesity Drugs Target Brain Activity to Curb Cravings

by Dr. Michael Lee – Health Editor November 17, 2025
written by Dr. Michael Lee – Health Editor

Breakthrough Study Reveals How Obesity Drugs like Zepatide Calm Compulsive Food ‍Cravings

PHILADELPHIA, PA⁤ – In a first-of-its-kind⁣ study, researchers have directly observed how blockbuster obesity drugs mimicking ⁢the hormone GLP-1, such as zepatide (marketed as Mounjaro or Zepbound), impact brain ​activity and suppress the intense, intrusive thoughts about food known as “food noise.” The findings, published today ‍in Nature Medicine1, offer‍ a crucial neurological insight into how ‍thes medications curb extreme cravings.

The research team, led ​by neurosurgeon-scientist​ Casey Halpern⁤ at the University of Pennsylvania, initially ‌aimed to test‌ deep brain stimulation as a treatment ⁤for compulsive eating in individuals​ for whom ‍other options, like bariatric surgery, had failed. ​Participants were‍ implanted with electrodes in ⁣the nucleus accumbens – a brain region involved ⁢in‌ reward and known ⁣to express the GLP-1 receptor.

However, a serendipitous chance arose when the third participant, a‌ 60-year-old woman, began taking a high dose of tirzepatide, prescribed‌ for‍ type 2⁢ diabetes,​ shortly before electrode ⁤implantation. Researchers then observed​ a significant change.

Prior to the medication, episodes ​of intense food ⁢noise in ‍the first ​two ⁣participants were accompanied by a surge ⁢in low-frequency brain activity, establishing a measurable neurological signature for compulsive ⁣food cravings.But⁤ in the third participant, ⁣after starting tirzepatide, ‍this pattern was notably diminished. The medication appeared to quiet the “food noise” by altering the electrical signals in the brain.

“it’s a great strategy to try and ​find a neural signature of food noise,‌ and then try to ⁣understand how drugs can manipulate it,” says Amber Alhadeff, a neuroscientist at the⁣ Monell Chemical Senses⁣ Center in Philadelphia, Pennsylvania.

christian Hölscher,a neuroscientist at the Henan academy​ of innovations in Medical Science in Zhengzhou,China,highlighted the importance of the ‍nucleus‍ accumbens,noting,”so we know that⁤ GLP-1 plays a role ‍in modulating reward here.”

The study represents a significant step forward ⁤in understanding the neurological mechanisms behind ​obesity and the effectiveness of GLP-1 mimicking ‌drugs.

1 https://www.nature.com/articles/d41586-022-04505-7

November 17, 2025 0 comments
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Technology

Vera C. Rubin Observatory Reveals Unexpected Stellar Stream

by Rachel Kim – Technology Editor November 8, 2025
written by Rachel Kim – Technology Editor

Rubin ‌Observatory’s First‍ light Reveals Unexpected Stellar Stream Behind Galaxy M61

Chile – In a⁢ stunning early result, the⁢ Vera C. Rubin Observatory has detected a ‌previously unseen stellar stream trailing the iconic‌ galaxy Messier 61, hinting at a past galactic‌ collision and demonstrating the‍ observatory’s potential to reshape our understanding of ​cosmic history. ‍The discovery was made while examining the observatory’s first test ⁢image, even before the commencement of its official scientific survey.

“This is the first stellar ‍stream detected from Rubin,” says ​Sarah Pearson, an astrophysicist at the University⁤ of Copenhagen. “And it’s just a precursor for all​ of the many, many features we’ll find‌ like this.” The findings have been reported⁤ in the Research Notes of ⁣the American Astronomical Society1.

Messier 61, first observed in 1779 within ‍the Virgo Cluster, is a well-studied “starburst galaxy” known for its high rate‍ of star⁢ formation and frequent supernovae. Despite extensive observation with powerful telescopes ⁤like the ‍James Webb and Hubble ⁢Space Telescopes, the stellar stream remained undetected until now.

“Despite all of ⁢this intense study, no one had ever found this stellar⁤ stream,” says Aaron Romanowsky, an astronomer at San Jose state University in California and a co-author⁣ of the study. The newly ⁢discovered stream suggests that ​Messier 61 gravitationally disrupted and absorbed a smaller galaxy, leaving ‍behind a trail of stars.

1 Research ‌Notes ⁤of the American Astronomical Society.

November 8, 2025 0 comments
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Health

The new frontier in understanding human and mammalian brain development

by Dr. Michael Lee – Health Editor November 6, 2025
written by Dr. Michael Lee – Health Editor

Brain Progress⁢ Across ‌Species Yields⁢ New ⁣Insights ⁢into ⁢Human Neurobiology

BOSTON, MA – A growing body of research, spearheaded by comparative studies‌ of mammalian brain development, is revealing fundamental principles governing how brains ⁤are built and how these processes translate‌ across ‌species – offering a new frontier in understanding ​human neurobiology and potential ⁣avenues for addressing developmental disorders. scientists are increasingly ⁤focused on identifying conserved “developmental ⁣time”‍ – a concept that maps stages of​ brain development not ‍by chronological ⁣age, but by the sequence of events occurring within the developing neural circuitry.

For decades, researchers have recognized that brain development doesn’t simply scale with body⁤ size or lifespan. A ⁤mouse brain ⁣matures much faster than a human brain, but corresponding developmental events-like‍ the formation of cortical layers or the refinement of neural connections-follow a similar order. This ‍realization has prompted‌ investigations into how these developmental sequences are ⁣”translated” between species, ​providing a powerful framework for studying human brain​ development, which‍ is frequently ‍enough difficult to​ access directly. understanding‌ these conserved principles ⁤could unlock new strategies for diagnosing and treating neurodevelopmental conditions affecting humans.

Key to this work ⁢are studies by researchers including B. ⁢Clancy, R.B. Darlington, ‍and B.L. Finlay, whose 2001 Neuroscience publication ⁤explored the concept of translating developmental⁤ time across⁤ mammals. Their work laid the groundwork for subsequent⁤ investigations into the​ underlying mechanisms ⁤governing ‌these transformations.

Building on⁤ this foundation, a 2013 study in The Journal of Neuroscience by‌ A.D. ⁤Workman, C.J. Charvet, B. ⁢Clancy, R.B. Darlington, and B.L. Finlay, detailed a⁣ modeling approach⁣ to understand ‌how neurodevelopmental sequences transform across mammalian species. This research, available through ⁤PubMed (23616543) and PubMed Central (PMC3928428), demonstrates ⁤that the ‍timing of developmental events can be predicted based on species-specific parameters, offering a quantitative framework for‍ comparative neurobiology.

These findings are not merely ‌academic.⁤ By leveraging the accessibility of ⁢animal ‌models, researchers can investigate the genetic and environmental factors influencing brain‌ development in ways that are unachievable in humans.‌ This comparative approach promises to accelerate ‍the revelation of biomarkers for neurodevelopmental disorders, refine existing therapies, and potentially lead to the development of novel interventions.⁣ The⁤ ongoing research signifies a paradigm​ shift, moving beyond species-specific descriptions of brain development toward a more unified understanding of⁤ the fundamental principles governing this complex process.

November 6, 2025 0 comments
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Health

Anti-progestin therapy targets hallmarks of breast cancer risk

by Dr. Michael Lee – Health Editor November 6, 2025
written by Dr. Michael Lee – Health Editor

New Research Reveals Anti-Progestin Therapy’s Potential to Disrupt Breast Cancer​ Risk Factors

A study​ published ‍in Nature details how anti-progestin ⁤therapy impacts key hallmarks of ⁤breast cancer risk, offering potential new avenues‌ for ⁢prevention and treatment. Researchers investigated the effects of ‍this therapy on cellular processes linked to cancer growth, utilizing quantitative PCR and ⁢Western blot analyses.

The⁤ study ‍employed Taqman universal PCR master mix (Applied biosystems, 4304437) with Thermo Fisher⁣ gene expression assays to measure the expression⁤ of TNFSF11 (Hs00243522_m1), SOX9 (Hs00165814_m1), and KIT (Hs00174029_m1), normalizing ⁣data ⁤against β-actin expression (Hs99999903_m1). Gene expression was assessed using⁣ a QuantStudio 5 Real-time PCR system (Thermo Fisher) and ⁣analyzed with ​QuantStudio Design and Analysis software (v2.6.0).

Protein levels were ‍analyzed via SDS-PAGE and ‍nitrocellulose membrane transfer, followed by incubation with primary antibodies – anti-SOX9 (sigma, AB5535), anti-KIT (R&D Biosystems, MAB332), and anti-β-actin (Sigma, A1978) – at dilutions of 1:1,000, 1:1,000, ⁣and 1:5,000 respectively. Secondary antibodies (Dako, goat anti-rabbit 41424306 and anti-mouse 41424131, both at 1:5,000 dilution) were used for detection⁣ with Classico,⁤ Forte (Millipore) or​ West Femto⁤ (Thermo Fisher) horseradish peroxidase reagents, visualized using a ChemiDoc Touch Imaging System ⁢(Bio-Rad). Densitometry was performed using Image⁤ Lab (v6.1; BioRad) ⁣with normalization‌ to β-actin.

Statistical significance was persistent using the Wilcoxon test (via the⁤ ‘ggpubr’ package, v0.6.0) with *P* values less than 0.05 ⁢considered notable. Data are ‍presented as median and interquartile range, connected by lines for paired data.

The clinical study received approval from the local ethics review ⁣committee ⁣and involved local researchers in all phases, from ‌design to publication authorship. A‌ detailed reporting summary is available as supplementary material.

November 6, 2025 0 comments
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Health

-title COVID-19 Surveillance: Tracking Infections and Emerging Variants

by Dr. Michael Lee – Health Editor November 4, 2025
written by Dr. Michael Lee – Health Editor

COVID-19 Cases Rise Globally with New Variants in Circulation

Geneva, switzerland – COVID-19 is ‍experiencing⁢ a resurgence ‍worldwide, prompting renewed monitoring of viral spread and variant evolution. While surveillance is ‍less comprehensive⁢ than during the height​ of the pandemic, health officials‌ are tracking hospitalizations and utilizing ⁤wastewater analysis to‌ assess the current situation.

Currently, the most prevalent ​variants are XFG, also known ⁢as ⁤Stratus ⁢or ‍the ‘Frankenstein variant,’ ⁤and NB.1.8.1, dubbed Nimbus. According to Maria Van Kerkhove, Stratus accounts for 76% of reported cases and is dominant‌ in Europe and⁣ the Americas. Nimbus is the leading ⁤variant in the Western Pacific region,⁤ representing 15% of‌ cases.​

“Hospital-based surveillance is what we’re mostly doing. But we also have wastewater surveillance,which is quite a useful ⁤indicator of what’s happening in the ‍community,” explains‍ Ho.

Both Stratus and Nimbus share symptoms with previous variants – including fever, cough, ‍and runny nose – but‍ Nimbus has been associated with a distinct ​symptom: a severe ‘razor blade’ ⁤sore throat. as⁢ of⁣ September 4th, both variants ‍are listed ⁤by the⁢ World Health Organization (WHO) ​as⁤ “currently circulating COVID-19 variants under monitoring.”

However,‍ complete data on viral circulation remains elusive.⁢ Fewer than 35 ⁢countries⁣ currently report COVID-19 hospitalization data ⁢to the WHO, highlighting gaps in ⁤global surveillance.⁤ “That’s why we’re trying to make sure that countries ⁤are still doing sequencing,”⁤ Van Kerkhove ⁢stated. despite these limitations, she affirmed that existing ⁢data ​are “sufficient to provide details ⁤to⁢ governments related to the‍ effectiveness ⁣of vaccines.”

Current vaccination⁢ campaigns ⁤primarily target individuals over 65 in the US,and those aged ‌75 or older in the UK ‌and parts of⁣ Europe,and also⁤ individuals with weakened immune ‍systems over 6 months ⁣of age. Epidemiologist⁢ Michael Head of the University of ⁣Southampton, UK, advocates ‍for broader vaccine distribution. “It’s still not a pleasant infection, and ‌vaccines do​ still⁤ have a important public-health benefit, so ⁤they are a vital tool in ​addressing the threat ‍posed⁣ by COVID-19.”

November 4, 2025 0 comments
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