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Kidney Disease: Early Symptoms Doctors Warn You Shouldn’t Miss

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

Silent Threat: Why Early Kidney Disease Detection is Crucial – and What to look For

World-Today-News.com – June 25, 2025 – Kidney disease is often a “silent” killer, progressing undetected until significant damage has occurred. Experts are now emphasizing the critical importance of recognizing subtle early warning signs to prevent the condition from escalating to kidney failure, dialysis, or even the need for a transplant.

The body does offer initial signals, but these are frequently overlooked because symptoms often manifest only after substantial kidney damage has taken place [[1]]. Dr. Chhya Vaja, an internal medicine expert at Apollo Spectra Mumbai, highlights that chronic kidney disease (CKD) typically develops gradually and quietly [source]. Many patients are only diagnosed when their kidneys are severely compromised, sometimes requiring immediate dialysis or even removal [source].

Early stages of CKD often present no noticeable symptoms, as the body can usually compensate for reduced kidney function [[2]]. However, being vigilant for potential indicators is vital. While these symptoms can be associated with other conditions, thay warrant a medical evaluation to rule out kidney disease [[1]].

Chronic kidney disease involves a gradual loss of kidney function, hindering the body’s ability to filter waste and excess fluids [[3]].Key takeaway: Don’t ignore potential warning signs. Early detection is paramount to preventing the progression of chronic kidney disease and preserving kidney function. Consult your doctor if you have any concerns.

CTA: Learn more about kidney health and risk factors at KidneyCareUK.org

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Health

New Diabetes & Obesity Drug: Promising Results, No Side Effects

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

New Type 2 Diabetes Drug Shows Promise in Lowering blood Sugar and Burning Fat

A groundbreaking study reveals a potential new oral drug for type 2 diabetes and obesity, demonstrating lower blood sugar and increased fat burning without the adverse effects of appetite suppression or muscle loss. Researchers from Karolinska Institutet and stockholm University published their findings in the journal Cell, highlighting the drug’s unique mechanism of action [[1]].

A Novel Approach to Diabetes Treatment

Unlike existing GLP-1-based drugs like ozempic, which are administered via injection and affect hunger through gut-brain signals, this new drug activates metabolism directly in skeletal muscle. Animal studies have shown promising results in blood sugar control and body composition without the side effects commonly associated with GLP-1 drugs.

did You No? The global prevalence of diabetes is estimated to be 10.5% (537 million people) in 2021, and is projected to rise to 12.2% (783 million) by 2045,according to the International Diabetes Federation [[2]].

Phase I Clinical Trial Results

an initial Phase I clinical trial involving 48 healthy individuals and 25 people with type 2 diabetes indicated that the treatment was well-tolerated in humans. This is a crucial step forward in determining the safety and efficacy of the drug.

“Our results point to a future where we can improve metabolic health without losing muscle mass. Muscles are crucial in both type 2 diabetes and obesity, and muscle mass is also directly correlated with life expectancy.”

Tore Bengtsson, Professor at Stockholm University

How the New Drug Works

The drug substance is based on a novel molecule, a type of β2 agonist developed in the laboratory. This molecule selectively activates signaling pathways in the body,positively affecting muscles without overstimulating the heart,a known issue with traditional β2 agonists.

Pro Tip: Maintaining a healthy lifestyle through diet and exercise remains a cornerstone of diabetes management, even with new drug therapies.

potential Benefits and Future Studies

“This drug represents a completely new type of treatment and has the potential to be of great importance for patients with type 2 diabetes and obesity,” says Shane C. Wright, Assistant Professor at Karolinska Institutet. “Our substance appears to promote healthy weight loss, and, in addition, patients do not have to take injections.”

The drug can be used alone or in combination with GLP-1 drugs due to their different mechanisms of action. Atrogi AB, the company developing the treatment, is planning a larger Phase II clinical study to assess the drug’s effects in people with type 2 diabetes or obesity.

Comparison of Diabetes Treatments
Treatment Type Mechanism of Action Administration Potential Side Effects
GLP-1 Drugs (e.g., Ozempic) Affects hunger via gut-brain signals Injection Loss of appetite, reduced muscle mass, gastrointestinal problems
New β2 Agonist Drug Activates metabolism in skeletal muscle Oral Tablet None reported in initial trials

Collaboration and Funding

The study involved collaboration between researchers from Karolinska Institutet, Stockholm University, Uppsala University, the University of Copenhagen, Monash University, and the University of Queensland.Funding was provided by the Swedish Research Council,the Swedish Society for Medical Research,and the Novo Nordisk Foundation,among others.

Several authors have affiliations with Atrogi AB, including Tore Bengtsson, the founder and chief scientific officer, who has applied for patents related to the investigated substances.

Understanding Type 2 Diabetes

type 2 diabetes is a chronic metabolic disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin. It is often associated with obesity, physical inactivity, and genetic predisposition. Effective management includes lifestyle modifications, medication, and regular monitoring of blood glucose levels.

Frequently Asked Questions about type 2 Diabetes and the New Drug

what is type 2 diabetes?

type 2 diabetes is a condition where the body doesn’t use insulin properly, leading to high blood sugar levels.

How does this new drug work for type 2 diabetes?

The new drug activates metabolism in skeletal muscle,helping to lower blood sugar and burn fat without affecting appetite or muscle mass.

Is the new diabetes drug better than existing treatments?

It offers a different mechanism of action and may avoid some side effects associated with GLP-1 drugs, but further studies are needed to confirm its long-term efficacy and safety.

What are the potential side effects of the new type 2 diabetes drug?

Initial trials showed good tolerance in humans, but larger studies are needed to identify any potential side effects.

Can this new drug cure type 2 diabetes?

No, this drug is a treatment to manage blood sugar levels and improve metabolic health, not a cure for type 2 diabetes.

When will the new type 2 diabetes drug be available?

The drug is currently in clinical trials. Its availability will depend on the results of these trials and regulatory approvals.

How does this new drug compare to Ozempic for treating type 2 diabetes?

Unlike Ozempic, which is injected and affects appetite, this new drug is an oral tablet that directly impacts muscle metabolism. It may offer an choice for those seeking different treatment options.

Disclaimer: This article provides details for general knowledge and informational purposes only, and does not constitute medical advice. It is indeed essential to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or treatment.

What are your thoughts on this new potential treatment for type 2 diabetes? How do you think it will impact the future of diabetes management?

Share your comments below and subscribe to World Today News for more updates on health and medical breakthroughs!

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Health

Alzheimer’s & Diet: Can Vegetables, Sugar & Grains Impact Risk?

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

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Combatting High Blood Sugar: Dietary Strategies to Prevent AGEs Accumulation

Table of Contents

new research highlights the critical role of diet in preventing the accumulation of Advanced Glycation End Products (AGEs), harmful compounds linked to aging and chronic diseases. Nutrition experts are urging individuals to adopt specific dietary habits to manage blood sugar levels and minimize AGEs formation, ultimately safeguarding their long-term health.

The Link Between High Blood Sugar and AGEs

When blood sugar remains elevated over time, excess glucose binds to proteins, fats, and even DNA, triggering a process called glycation. This glycation process leads to the formation of AGEs, which act like “aging garbage” in the body, hardening tissues and promoting inflammation. According to a Facebook post by nutrition scholar Hong Taixiong,excessive AGEs accumulation is associated with accelerated skin aging,increased risk of cardiovascular disease,and even links to Alzheimer’s disease and cancer.

Did You Know? AGEs can accumulate in the body from both internal metabolic processes and external sources like processed foods cooked at high temperatures.

The Consequences of AGEs Accumulation

The accumulation of AGEs can have far-reaching consequences for overall health. These compounds contribute to:

  • Accelerated skin aging
  • Aggravated vascular complications in diabetes
  • Increased risk of cardiovascular disease
  • Damage to kidneys, eyes, and nerves
  • Potential links to Alzheimer’s disease and cancer

Top 10 Dietary Strategies to Prevent AGEs

To combat the harmful effects of AGEs, nutrition experts recommend incorporating these ten key foods into your daily diet:

  1. Dark Green Leafy Vegetables: Spinach, kale, and cabbage are rich in vitamin C, folic acid, and antioxidant phytochemicals, which neutralize free radicals and stabilize blood sugar.
  2. Beans: Soybeans, black beans, and red beans offer plant protein, dietary fiber, and isoflavones, aiding in blood sugar stabilization and reducing inflammation.
  3. Whole grains: Brown rice, oats, and quinoa are packed with B vitamins, minerals, and dietary fiber, promoting a steady release of blood sugar and minimizing post-meal spikes.
  4. Citrus Fruits: Oranges, grapefruits, and lemons provide vitamin C and flavonoids, which directly inhibit glycation and protect blood vessels.
  5. Berries: Blueberries, strawberries, and cranberries boast high levels of polyphenols and anthocyanins, offering potent antioxidant power to eliminate free radicals and protect the nervous and cardiovascular systems.
  6. Tomatoes: Lycopene and vitamin C in tomatoes act as strong antioxidants, reducing AGEs accumulation, protecting the skin, and reducing inflammation.
  7. Deep-Sea Fish: Salmon, mackerel, and sardines are rich in Omega-3 fatty acids, which help reduce chronic inflammation and improve insulin sensitivity.
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Health

Diabetes Drug Cuts Migraines in Half, Study Finds

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

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GLP-1 Agonist Shows Promise in Reducing Migraine Frequency

Table of Contents

A diabetes drug that lowers brain fluid pressure has slashed monthly migraine days by more than half, according to research presented at the European Academy of Neurology (EAN) Congress 2025. The study highlights a potential new avenue for migraine treatment using GLP-1 agonists.

Liraglutide Reduces Migraine Days

Researchers at the Headache Center of the University of Naples “Federico II” administered the glucagon-like peptide-1 (GLP-1) receptor agonist liraglutide to 26 adults with obesity and chronic migraine (defined as ≥15 headache days per month). The results, presented at the EAN Congress 2025, showed a significant reduction in migraine frequency.

Patients reported an average of 11 fewer headache days per month, and their scores on the Migraine Disability Assessment Test (MIDAS) dropped by 35 points. This indicates a clinically meaningful advancement in their ability to function at work, in their studies, and in social settings.

Did You Know? The global prevalence of migraine is estimated to be around 14%, affecting approximately one in seven adults worldwide [[WHO Fact Sheet]].

The Role of Intracranial Pressure

The study suggests that the benefit of liraglutide in reducing migraine frequency is linked to its ability to modulate cerebrospinal fluid pressure. Participants were screened to exclude papilledema (optic disc swelling) and sixth nerve palsy, ruling out idiopathic intracranial hypertension (IIH) as a primary factor.

Dr. simone Braca,the lead researcher,explained,”we think that,by modulating cerebrospinal fluid pressure and reducing intracranial venous sinuses compression,these drugs produce a decrease in the release of calcitonin gene-related peptide (CGRP),a key migraine-promoting peptide. That would pose intracranial pressure control as a brand-new,pharmacologically targetable pathway.”

Study Findings

While participants experienced a slight decrease in body-mass index (BMI) from 34.01 to 33.65, this change was not statistically significant. An analysis confirmed that BMI reduction did not affect headache frequency, reinforcing the idea that pressure modulation, rather than weight loss, drives the benefit.

Pro Tip: Maintaining a healthy lifestyle, including regular exercise and a balanced diet, can help manage migraine symptoms and reduce the frequency of attacks [[Mayo Clinic – Migraine Treatment]].

Side Effects and Future Research

Mild gastrointestinal side effects, mainly nausea and constipation, occurred in 38% of participants but did not lead to treatment discontinuation.The research team is now planning a randomized, double-blind trial with direct or indirect intracranial pressure measurement to further investigate these findings.

Professor Roberto De Simone, who leads the research team in Naples, stated, “We also want to determine whether other GLP-1 drugs can deliver the same relief, possibly with even fewer gastrointestinal side effects.”

Potential for Drug Repurposing

If confirmed, GLP-1-receptor agonists could offer a new treatment option for the estimated one in seven people worldwide who live with migraine, particularly those who do not respond to current preventives [[1]]. Given liraglutide’s established use in type 2 diabetes and obesity, it may represent a promising case of drug repurposing in neurology.

The following table summarizes the key findings of the study:

Metric Result
Average reduction in headache days per month 11 days
Reduction in MIDAS score 35 points
Percentage of participants with gastrointestinal side effects 38%

Implications for Migraine Treatment

The study suggests that GLP-1 agonists, typically used for diabetes and weight management, may offer a novel approach to migraine prevention by targeting intracranial pressure. This could be particularly beneficial for individuals who have not found relief with existing migraine treatments.

What are your thoughts on repurposing existing drugs for new treatments? How do you manage your migraine symptoms?

Evergreen Insights: Understanding Migraine and GLP-1 Agonists

migraine is a complex neurological disorder characterized by recurrent headaches, often accompanied by symptoms such as nausea, vomiting, and sensitivity to light and sound.While the exact cause of migraine is not fully understood, it is indeed believed to involve a combination of genetic and environmental factors.

GLP-1 agonists are a class of drugs that mimic the effects of glucagon-like peptide-1 (GLP-1), a hormone that helps regulate blood sugar levels. These drugs are commonly used to treat type 2 diabetes and, in certain specific cases, for weight management. Liraglutide is one example of a GLP-1 receptor agonist.

The potential link between GLP-1 agonists and migraine lies in their ability to influence intracranial pressure and reduce the release of CGRP, a peptide known to play a role in migraine development. further research is needed to fully understand this connection and determine the long-term efficacy and safety of GLP-1 agonists for migraine prevention.

Frequently Asked Questions About GLP-1 Agonists and Migraine

  • What are GLP-1 receptor agonists?

    GLP-1 receptor agonists are a class of drugs that mimic the effects of glucagon-like peptide-1 (GLP-1),a hormone that helps regulate blood sugar levels. These drugs are commonly used to treat type 2 diabetes and, in some cases, for weight management. Semaglutide is one example of a GLP-1 receptor agonist [[3]].

  • How might GLP-1 agonists help with migraine?

    Research suggests that GLP-1 receptor agonists, such as liraglutide, may reduce migraine frequency by modulating cerebrospinal fluid pressure and reducing intracranial venous sinuses compression. This could lead to a decrease in the release of CGRP, a peptide known to promote migraines.

  • What is Liraglutide?

    Liraglutide is a GLP-1 receptor agonist primarily used to treat type 2 diabetes. A recent study presented at the European Academy of Neurology (EAN) Congress 2025 indicates it may also significantly reduce migraine frequency in individuals with obesity and chronic migraine.

  • What are the side effects of liraglutide?

    The most common side effects of liraglutide are mild gastrointestinal issues, such as nausea and constipation. in the study presented at the EAN Congress 2025, these side effects were reported by 38% of participants but did not lead to treatment discontinuation.

  • Are GLP-1 agonists approved for migraine treatment?

    Currently,GLP-1 agonists are not specifically indicated for migraine treatment [[3]].However, research is ongoing to explore their potential benefits for migraine sufferers, particularly those who do not respond well to existing treatments [[1]].

  • What is idiopathic intracranial hypertension (IIH)?

    Idiopathic intracranial hypertension (IIH) is a condition characterized by increased pressure around the brain. GLP-1 agonists have shown promise in treating IIH by reducing cerebrospinal fluid secretion

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Health

Carb Responses: A New Window into Your Metabolic Health

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

Personalized Blood Sugar Responses to Carbs Key to Diabetes Prevention

Table of Contents

Individual blood sugar responses to carbohydrates vary substantially based on metabolic health, impacting the risk of prediabetes and type 2 diabetes. A recent study published in Nature Medicine highlights that these variations are linked to conditions like insulin resistance and beta-cell dysfunction, suggesting a need for personalized dietary guidelines. Understanding these individual responses could revolutionize diabetes prevention and treatment.

The Science Behind Postprandial Glycemic Responses

High postprandial glycemic responses (PPGRs) refer to the fluctuations in glucose levels after a meal, representing the body’s reaction to carbohydrates. These PPGRs are closely tied to beta cell function and are considered risk factors for prediabetes and type 2 diabetes (T2D). However, a complete understanding of glucose dysregulation in terms of PPGRs has been limited due to the complexity of metabolic functions, including insulin resistance and secretion.

To delve deeper into individual PPGRs and their connections to metabolic subtypes,researchers conducted a study involving 55 individuals without a history of T2D. Participants underwent metabolic testing for insulin resistance and beta cell dysfunction, along with multi-omics profiling, which included assessments of triglyceride levels, blood metabolites, liver function, and gut microbiome data.

Did You Know? The global prevalence of diabetes is estimated to be 10.5%, affecting 537 million adults in 2021, according to the International Diabetes Federation. This number is projected to rise to 12.2% (783 million) by 2045, underscoring the urgency of effective prevention strategies.

Key Findings: How Different Carbs affect Blood Sugar

The study revealed distinct blood sugar responses to various carbohydrates among participants. Individuals with insulin resistance experienced the highest blood sugar spikes after consuming pasta, while potatoes caused the greatest spikes in those with either insulin resistance or beta cell dysfunction. Multi-omics analysis further showed that potato-sensitive individuals also had elevated levels of triglycerides and fatty acids, consistent with insulin resistance.

Conversely, beans triggered blood sugar spikes linked with histidine and keto metabolism, indicating the body’s use of fat for energy. These findings suggest that different metabolic subtypes respond uniquely to specific carbohydrates, highlighting the need for tailored dietary recommendations.

Pro Tip: Consider using a food diary or a glucose monitoring system to track your individual blood sugar responses to different foods.This can help you identify which carbohydrates are best suited for your metabolic profile.

Specific Food Reactions and Metabolic Markers

Further analysis revealed that individuals with elevated blood sugar after eating bread were more prone to hypertension. Notably,the differing blood glucose responses between potatoes and grapes were associated with insulin resistance,potentially serving as a future biomarker for the condition. This biomarker could be invaluable for early diagnosis and intervention, as insulin resistance is often asymptomatic.

According to the CDC, more than 88 million U.S. adults have prediabetes, and more than 84% of them don’t know they have it. early detection and lifestyle changes can significantly reduce the risk of developing type 2 diabetes.

“such a biomarker would be useful as insulin resistance is amenable to lifestyle and medication interventions that can reduce risk for diabetes in high-risk individuals. At present there is no easy way to diagnose it in the clinic,” explained Dr. Tracey McLaughlin,professor of endocrinology and co-lead study author.

Implications for Diabetes Prevention and Treatment

The findings suggest that understanding these personalized blood sugar responses could aid more tailored prevention and treatment approaches for prediabetes and diabetes. By identifying individual metabolic subtypes and their specific reactions to carbohydrates, healthcare providers can develop targeted dietary plans to manage blood sugar levels effectively.

“Eating carbohydrates later in a meal is still a good idea even though it has not yet been sorted out whether it is best to eat protein, fat, or fiber before carbohydrates,” saeid Dr. Michael Snyder, professor in genetics. “Eat your salad or hamburger before your French fries.”

Carbohydrate Metabolic Condition Blood Sugar Response
Pasta insulin Resistance Highest Spikes
Potatoes Insulin Resistance or Beta Cell Dysfunction Greatest Spikes
Beans N/A Linked to Histidine and Keto Metabolism
Bread N/A Linked to Hypertension

The Ever-Evolving Landscape of Diabetes Research

Diabetes research has significantly evolved over the past few decades, shifting from generalized dietary advice to more personalized approaches. Historically, dietary guidelines for diabetes management focused on limiting overall carbohydrate intake. However, recent studies, including the one highlighted, emphasize the importance of understanding individual metabolic responses to different types of carbohydrates.

This shift is driven by advancements in technology, such as continuous glucose monitors (CGMs), and a deeper understanding of the human microbiome and its impact on metabolic health. As research continues, personalized nutrition plans tailored to individual metabolic profiles are likely to become the standard of care for diabetes prevention and management.

Frequently Asked Questions About Blood Sugar and Carbohydrates

How can I improve my blood sugar control?
Improving blood sugar control involves a combination of dietary changes,regular physical activity,and,in some cases,medication. Focus on consuming a balanced diet with plenty of non-starchy vegetables,lean proteins,and healthy fats. Regular exercise can also help improve insulin sensitivity and lower blood sugar levels.
What are the best carbohydrates for managing blood sugar?
The best carbohydrates for managing blood sugar are those that are slowly digested and have a lower glycemic index. Examples include whole grains, legumes, and non-starchy vegetables. these foods provide a steady release of glucose into the bloodstream, preventing rapid spikes in blood sugar levels.
How frequently enough should I check my blood sugar levels?
The frequency of blood sugar monitoring depends on individual circumstances and treatment plans. Individuals with diabetes who are on insulin may need to check their blood sugar levels several times a day,while those managing their diabetes with diet and exercise may onyl need to check occasionally. Consult with your healthcare provider to determine the appropriate monitoring schedule for you.
What are the symptoms of high blood sugar?
symptoms of high blood sugar can include increased thirst, frequent urination, blurred vision, fatigue, and slow-healing sores. If you experience these symptoms, it is important to check your blood sugar levels and seek medical attention if necessary.
Can stress affect blood sugar levels?
Yes, stress can significantly impact blood sugar levels. When you are stressed, your body releases hormones that can raise blood sugar levels. Managing stress through relaxation techniques, exercise, and adequate sleep can help stabilize blood sugar levels.

Disclaimer: This article provides general details about blood sugar and diabetes. It is indeed not intended to be a substitute for professional medical advice. Always consult with a qualified healthcare provider for any questions you may have regarding your health or treatment.

What are your thoughts on personalized nutrition for diabetes prevention? Share your experiences and questions in the comments below!

Enjoyed this article? Share it with your friends and family to spread awareness about the importance of personalized blood sugar management.

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Health

Semaglutide Shows Early Heart Benefits: SELECT Trial Results

by Chief editor of world-today-news.com
written by Chief editor of world-today-news.com

Semaglutide’s rapid Impact on Heart Health: New Insights from SELECT Trial

Semaglutide, a medication initially developed for type 2 diabetes, is showing promise in rapidly reducing the risk of heart attacks and other serious cardiovascular complications in adults with overweight or obesity who have pre-existing cardiovascular disease but not diabetes. This is according to a secondary analysis of the Semaglutide and Cardiovascular Outcomes (SELECT) trial, presented at the European Congress on Obesity (ECO) in Malaga, Spain.

Early Benefits Observed

The analysis focused on the early impact of semaglutide on cardiovascular events, examining data from randomization up to 12 months, with a specific focus on the 3- and 6-month marks. Researchers aimed to understand the drug’s effects, the timeline for cardiovascular benefits, and identify potential predictors for early cardiovascular events.

Did you know? Semaglutide mimics the body’s natural incretin hormones, which help regulate blood sugar levels and promote feelings of fullness, aiding in weight loss.

These results highlight semaglutide’s early action on decreasing major cardiovascular events, with notable benefits already evident by the first 6 months, and for some, even earlier, even before any major weight loss and before most patients would have been titrated to their full target dose of 2.4 mg.

Dr. Jorge Plutzky, Director of Preventive Cardiology, Cardiovascular Medicine at Brigham and Women’s Hospital, Boston, MA

SELECT Trial Background

The SELECT trial, a landmark study from 2023, demonstrated that adults with overweight or obesity but without diabetes, who had a history of heart attack, stroke, or peripheral artery disease, experienced a 20% reduction in major adverse cardiac events (MACE) when taking semaglutide compared to a placebo over three years. It is important to note that SELECT was not designed as a weight loss trial; participants received semaglutide or a placebo without specific dietary or weight loss guidance.

Study Details and Key Findings

The study involved 17,604 adults (72% male, aged 45 or older) from 804 sites across 41 countries. All participants had overweight or obesity, defined as a body mass index (BMI) of 27 kg/m² or higher. Participants received weekly injections of either semaglutide (titrated to 2.4 mg by week 16) or a placebo.

  • 3-Month Results: Semaglutide was associated with a 38% reduction in the risk of major adverse cardiovascular events (MACE) compared to the placebo group (36 vs. 58 events, respectively).
  • 6-Month Results: The risk of MACE was reduced by 41% in the semaglutide group compared to the placebo group (67 vs.113 events, respectively).
  • Early Stage Impact: Notably, at both 3 and 6 months, most patients had not experienced significant weight loss and were not yet at the full target dose of 2.4 mg of semaglutide weekly.

Mechanisms and future Research

Our findings reveal an early separation in the treatment effect of semaglutide that occurs even without a significant amount of weight lost and prior to full semaglutide titration, said Dr. Plutzky.He added, More research is needed to understand the mechanisms through which semaglutide produces these early clinical benefits, but they may include the drug’s positive effects on reducing inflammation, blood sugar, blood pressure, direct effects on the heart and blood vessels, early dietary changes, or an interaction among these or other responses.

Pro Tip: While semaglutide shows promise, it’s crucial to consult with a healthcare professional to determine if it’s the right treatment option for you, considering your medical history and current medications.

Important Considerations

The researchers emphasized that the SELECT trial focused on individuals with a history of heart disease, placing them at high risk for cardiovascular events. these patients were already taking other cardio-protective medications to manage cholesterol and blood pressure. The benefits of semaglutide were observed along with these existing treatments.

Frequently Asked Questions (FAQ)

What is semaglutide?
Semaglutide is a GLP-1 medication initially approved for treating adults with type 2 diabetes, and also approved for weight loss in people with obesity or overweight who have at least one other health issue.
Who can benefit from semaglutide?
Adults with overweight or obesity who have pre-existing cardiovascular disease but not diabetes may benefit from semaglutide.
How quickly does semaglutide work?
The SELECT trial showed significant cardiovascular benefits within the first 3 to 6 months of treatment, even before significant weight loss occurred.
Does semaglutide replace other heart medications?
No, semaglutide’s benefits were observed in addition to existing cardio-protective medications. Consult with your doctor before making any changes to your medication regimen.
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