Inactivated COVID-19 Vaccine Shows Promise in Dampening Inflammation, Mouse Study Finds
Jakarta, Indonesia โข- As the world continues to grapple with the long-term effects of โขthe COVID-19 pandemic, research into vaccine efficacy and safety remains paramount. A new study published in Jurnal kedokteran Hewan dan Veteriner (Journal of Medical and Veterinary Science) offers encouraging data regardingโข the impact of an inactivated โขSARS-CoV-2 vaccine candidate on inflammatory responses in a mouse model. The research, conducted by Covered Abdul โคRantam, suggests the vaccine is safe and effectivelyโ modulates key inflammatory markers.
Theโค study focused on K18-hACE2 mice, aโ genetically engineered strain that expresses โthe human angiotensin-converting enzyme 2 (hACE2) receptor โ- the protein thatโ SARS-CoV-2 uses to enter cells. This makesโ them a โvaluable model forโ studying COVID-19 in aโฃ laboratory โsetting. Researchers comparedโค the effects of the inactivatedโ vaccine candidate against a placebo (pseudo vaccine) andโ a carrierโ vaccine.
Aโฃ key objective was โto assess the vaccine’s impact on body weight, a common indicator of overall health, โฃand levels of pro-inflammatory cytokines – signaling molecules that play a crucial role in the body’s immune response. Theseโข cytokines included interleukin-4 (IL-4),โฃ interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-ฮฑ), and interferon-gamma (IFN-ฮณ).
The findings revealedโค that administration of the inactivated โvaccine candidateโ did not โresult inโ critically important weightโค changes โฃin the mice comparedโ to the control group.More importantly, theโ study demonstrated a significant reduction in the levels of all four measured cytokines (IL-4, IL-6, TNF-ฮฑ, and IFN-ฮณ) inโ vaccinated mice. This suggests theโ vaccine effectively dampened the inflammatory response, a hallmark of severe COVID-19.
“These results indicate a favorable safetyโข profile and potential benefits associated with this inactivated SARS-CoV-2 vaccine candidate,” explains the study. “The ability to regulate these key inflammatory markers is crucial in mitigating the โseverityโ of COVID-19 and โpreventing long-term complications.”
While further research is โneeded, these findingsโค contribute valuable data to the ongoing effortโ to develop safe and effective COVID-19 vaccines. The study underscores the importanceโ of understanding not only a vaccine’s ability to generate an immune response, but also its impact on the inflammatory cascade โthat can drive severe disease.
Source: โ Evaluation and its Impact of โคSARS-CoV-2 Inactivated Vaccine Candidateโค in K18-hACE2 mice. jur. Med.Vet.; โVol.8 No.1, 54-62. โฃAvailable at: https://e-journal.unair.ac.id/JMV
SEO Notes:
Keywords: COVID-19 vaccine, inactivated vaccine,โ SARS-CoV-2, inflammation,โข cytokines, K18-hACE2 mice, vaccine safety, vaccine efficacy, Indonesia, research.
Target โฃAudience: General public interested inโค COVID-19 news,โ medical professionals, researchers.
Meta Description: New research shows an inactivated COVID-19 vaccine candidate effectively reduces inflammation in a โmouse model,โ suggesting a safe and beneficial profile.
Headline Optimization: Clear,โ concise, and includes โฃkey keywords.
Internal Linking: (Would add links โคto other relevant COVID-19โฃ articles on world-today-news.com โคif available).
external Linking: Direct link to the original research article provided.
