Hanmi pharm’s HM15275 Shows Promise in Obesity Treatment with Significant Weight Loss
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- Hanmi pharm’s HM15275 Shows Promise in Obesity Treatment with Significant Weight Loss
Chicago, IL – June 22, 2025 – Hanmi Pharmaceutical unveiled encouraging results from the Phase 1 clinical trial of its next-generation obesity treatment, HM15275, at the 85th American Diabetes Association (ADA) meeting in Chicago. The study demonstrated significant weight loss in participants, paving the way for further progress of this innovative drug. The company also presented preclinical data on HM17321, a novel drug candidate designed to promote both weight loss and muscle gain.
HM15275: A Novel Approach to Weight Management
HM15275 is a triple-acting agent (LA-GLP/GIP/GCG) designed to combat obesity by suppressing appetite and boosting energy metabolism. The Phase 1 clinical trial, involving 74 healthy and obese adults, evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of HM15275 administered subcutaneously once a week for four weeks.
Did You Know? Obesity affects over 40% of adults in the united States, increasing the risk of heart disease, stroke, type 2 diabetes, and certain types of cancer [1].
Key Findings from the Phase 1 Trial
The results of the Phase 1 trial were promising. Participants in the highest dose group (0.5-2-4-8mg) experienced an average weight loss of 4.81% compared to the placebo group after just four weeks of treatment. Notably, some participants exhibited a maximum weight loss of 10.64% on day 43, indicating a sustained effect even after the treatment period.
Lee Moon-hee, head of the GM Clinical Team at Hanmi Pharm, stated that the trial verified the safety of HM15275 and provided valuable data for determining the starting dose and escalation strategy for Phase 2 clinical trials.
Hanmi Pharm also presented data suggesting that HM15275 may offer superior weight reduction compared to existing obesity treatments like Semaglutide (Ozempic) and Tirzepatide (Mounjaro). These medications, while effective, can have side effects and may not be suitable for all patients [2].
HM17321: Targeting Weight Loss and Muscle Gain
Along with HM15275, Hanmi Pharm is developing HM17321, a UCN 2 analog that selectively targets the CRF2 receptor.This novel drug candidate aims to achieve both weight loss and muscle growth, addressing a critical need in obesity management. Sarcopenic obesity, characterized by the loss of muscle mass alongside increased fat, is a growing concern, particularly among older adults [3].
Preclinical Data Shows Promising results
Preclinical studies on HM17321 in rodent obesity models demonstrated significant improvements in body composition. The studies confirmed that the muscles generated through HM17321 dosing exhibited actual metabolic function, suggesting a potential for improved overall health.
Pro Tip: Maintaining muscle mass during weight loss is crucial for preserving metabolic rate and preventing weight regain.
Hanmi pharm’s Commitment to Innovation
Hanmi Pharmaceutical’s presentation at ADA 2025 underscores its commitment to developing innovative solutions for obesity and related metabolic disorders. The company’s pipeline includes a range of promising drug candidates, each with a unique mechanism of action and the potential to address unmet needs in the treatment of obesity.
| Drug Candidate | Mechanism of action | Trial Phase | Key Findings |
|---|---|---|---|
| HM15275 | LA-GLP/GIP/GCG (Triple Agonist) | Phase 1 | Significant weight loss, good safety and tolerability |
| HM17321 | UCN 2 Analog (CRF2 Receptor Agonist) | Preclinical | Weight loss and muscle gain in rodent models |
What are your thoughts on the potential of HM15275 and HM17321 to revolutionize obesity treatment?
How importent is it to maintain muscle mass while losing weight?
the growing Obesity Epidemic: A Global Health crisis
Obesity has become a global health crisis, affecting millions of people worldwide. The World Health Organization (WHO) estimates that over 650 million adults are obese [4]. This chronic disease is associated with a wide range of health complications, including type 2 diabetes, cardiovascular disease, certain cancers, and musculoskeletal disorders.
The rise in obesity rates is attributed to a combination of factors, including changes in dietary habits, decreased physical activity, and genetic predisposition. Addressing this complex issue requires a multi-faceted approach, including lifestyle modifications, pharmacological interventions, and public health initiatives.
Frequently Asked Questions About Obesity Treatment
- What are the current treatment options for obesity?
- Current treatment options for obesity include lifestyle modifications (diet and exercise), medications, and bariatric surgery.The choice of treatment depends on the individual’s health status, weight loss goals, and preferences.
- How effective are weight loss medications?
- Weight loss medications can be effective in promoting weight loss when combined with lifestyle modifications. However, they may have side effects and are not suitable for everyone. It is important to discuss the risks and benefits of weight loss medications with a healthcare professional.
- What is bariatric surgery?
- Bariatric surgery is a surgical procedure that helps people with severe obesity lose weight. It works by reducing the size of the stomach or altering the digestive process.Bariatric surgery is a major procedure and carries risks,but it can be an effective option for individuals who have not been successful with other weight loss methods.
- What are the long-term health benefits of weight loss?
- Weight loss can have significant long-term health benefits, including reduced risk of type 2 diabetes, cardiovascular disease, certain cancers, and improved quality of life. Even modest weight loss (5-10% of body weight) can have a positive impact on health.
- How can I prevent weight regain after weight loss?
- preventing weight regain after weight loss requires a long-term commitment to healthy lifestyle habits,including regular physical activity,a balanced diet,and stress management. It is indeed also critically important to seek support from healthcare professionals and support groups.
Disclaimer: This article provides data about potential new treatments for obesity. It is not intended to provide medical advice. Please consult with a healthcare professional for personalized guidance on weight loss and treatment options.
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