Prostate Cancer Can Present with Unexpected Skin Changes: What to Watch For
New York, NY - September 24, 2025 – While often associated with urinary difficulties, prostate cancer can sometimes manifest with subtle yet critical warning signs on the skin, including the development of nodules, papules, and other dermal changes. Recognizing these less-common symptoms could be vital for earlier diagnosis and improved treatment outcomes for the roughly 299,000 men expected to receive a prostate cancer diagnosis in the United States this year, according to the American Cancer Society.
Prostate cancer’s progression can, in rare instances, lead to cutaneous metastases – the spread of cancer cells to the skin. These manifestations aren’t typically the frist indication of the disease, but their appearance warrants immediate medical evaluation. Delayed diagnosis can significantly impact prognosis, underscoring the importance of awareness among both men at risk and healthcare providers. This information is particularly crucial as prostate cancer remains the second leading cause of cancer death in American men, with approximately 34,520 fatalities projected for 2025.
Skin Manifestations to Be Aware Of
The skin changes associated with prostate cancer are diverse and can be easily mistaken for other, benign conditions. However, persistent or unusual skin alterations should prompt a consultation with a dermatologist or oncologist. Key signs include:
* nodules: firm, raised bumps under the skin, often painless, can appear on the chest, abdomen, back, or thighs.
* Papules: Small, raised bumps, sometimes resembling pimples, that may be skin-colored, red, or purple.
* Plaques: Flat, raised areas of skin that may be scaly or discolored.
* Ulcers: Open sores that don’t heal readily.
* Skin Discoloration: Unusual changes in skin pigmentation.
* Itching: Persistent, localized itching without an obvious cause.
These skin lesions typically develop due to cancer cells traveling through the lymphatic system or bloodstream to reach the skin. While cutaneous metastases are uncommon, accounting for less than 5% of prostate cancer cases, they represent a serious progression of the disease.
Who is at Risk and What to Do
Men over the age of 50, those with a family history of prostate cancer, and African American men are at higher risk of developing the disease. Regular prostate exams, including a digital rectal exam and prostate-specific antigen (PSA) blood test, are recommended for early detection.
If you notice any unusual skin changes, particularly if you have been diagnosed with prostate cancer or have risk factors for the disease, consult a healthcare professional promptly. Early detection and treatment of cutaneous metastases can improve quality of life and potentially extend survival. A biopsy of the affected skin can confirm the presence of cancer cells and guide appropriate treatment strategies, wich may include radiation therapy, chemotherapy, or hormone therapy.
