Ozempic Users Report Shift in Libido, Experts Weigh In

Weight-loss drug linked to decreased interest in sexual activity

Users of the popular weight-loss medication Ozempic are reporting a significant drop in their libido, with some noting a reduced interest in masturbation. Experts are now exploring how these GLP-1 medications might be impacting sexual desire.

The ‘Ozempic Masturbation’ Phenomenon

Ozempic, whose active ingredient is semaglutide, was initially approved by the US Food and Drug Administration (FDA) in 2017 for managing blood sugar levels in individuals with type 2 diabetes. While not officially licensed as a weight-loss treatment, its ability to regulate appetite and promote satiety has led to its widespread off-label use for shedding pounds. Common side effects include nausea, diarrhea, and abdominal pain. However, a growing number of users are experiencing what is being termed ‘Ozempic masturbation,’ a phenomenon characterized by a diminished sex drive.

Clinical research into Ozempic’s specific effects on sex drives is still in its nascent stages. However, some initial findings suggest a potential correlation. American telehealth company Ro has indicated that preliminary research points to possible links between the medication and fluctuations in libido, either increases or decreases.

Anecdotal reports suggest that rapid weight loss, a common outcome of Ozempic use, can place stress on the body, potentially contributing to side effects such as erectile dysfunction. Beyond physical impacts, many users report a marked decline in their overall libido and a significantly reduced interest in activities like watching pornography and masturbating.

Personal Accounts of Altered Libido

Social media platforms have become a space for individuals to share their experiences. One user on Reddit described a dramatic shift: “Before semaglutide I used porn every day and was addicted. Now I use it maybe 5 min a week and don’t find it that interesting.” In a follow-up, they added, “After Ozempic, I almost [have quit] porn. My interest in normal sex is the same, but maybe my libido is a bit lower (but I like that).”

Another user noted a similar trend, stating, “Mine is down, but now I just don’t masturbate but still have the same amount of sex.” Many attribute these changes to their ‘dopamine reward system’ being altered, suggesting that cravings for food, pornography, and even shopping are substantially reduced.

Expert Insights on Libido Changes

Eric Smith, a bariatric surgeon and medical director of POP Recovery Systems, suggests that these changes in libido experienced by patients on medications like Ozempic are typically temporary. He stated, “For most patients, symptoms improve within a few weeks as their body adjusts to the medication. Proper dose regulation often helps resolve these issues.”

To address a sudden lack of desire to masturbate, lifestyle adjustments are recommended. Dr. Michael Tahery, a urogynecologist, advises that a balanced diet, regular exercise, and adequate sleep can boost mood and sex drive by increasing dopamine receptor stimulation. Open communication with partners is also encouraged.

Beyond medication effects, psychological factors such as stress and depression can significantly impact sexual desire. Studies have historically linked anxiety disorders to reduced sexual desire, difficulty achieving orgasm, and sexual pain.

Novo Nordisk, the manufacturer of Ozempic, emphasized patient safety. A spokesperson advised, “Patient safety is of the utmost importance to Novo Nordisk, and we recommend patients take these medications for their approved indications and under the supervision of a healthcare professional.” They added that the company continuously monitors safety data and encourages patients experiencing side effects to report them to their healthcare provider and via the MHRA Yellow Card scheme.