Pancreatic Cancer Projected to Become Second Leading Cause of Cancer Death in Europe
LYON, FRANCE – Pancreatic cancer is on track to overtake colorectal cancer as the second deadliest cancer in Europe, raising urgent concerns among oncologists and prompting a surge in research focused on early detection and innovative therapies. Currently the third leading cause of cancer death, the aggressive nature of the disease and challenges in early diagnosis are driving the grim forecast.
The rising incidence,coupled with the often-late stage at diagnosis,is fueling the projected increase in mortality. unlike some cancers, pancreatic cancer often presents with vague symptoms, delaying crucial intervention. This is prompting a shift towards proactive strategies,including liquid biopsies for early detection and novel immunotherapies designed to bolster the body’s natural defenses. “detect pancreatic cancer as early as possible using a liquid biopsy,a simple blood sample,” explains Professor Sandrine Dabernat,from the Bordeaux Oncology Research Institute. “This approach analyzes the biological specificities of immune cells associated with the detection of precancerous pancreatic lesions or pancreatic cancer at an early stage.”
Researchers are exploring groundbreaking approaches to combat the disease. Professor Dabernat’s team at the Bordeaux Oncology Research Institute is pioneering a gene therapy designed to disrupt the tumor microenvironment and attract anti-tumor immune cells, paving the way for cellular immunotherapy. This involves introducing modified viruses to target pancreatic cancer cells, rendering them vulnerable to attack by the immune system.
Early diagnosis remains paramount, and vigilance regarding potential symptoms is crucial.The Léon-Bérard cancer center in Lyon highlights several warning signs that warrant medical attention: jaundice, abdominal pain, pain in the middle of the back, new onset diabetes, thrombosis, changes in intestinal transit, unexplained weight loss, nausea, and symptoms of depression.
For more facts about pancreatic cancer, resources are available through the National Cancer Institute (Inca) at https://www.cancer.fr/personnes-malades/les-cancers/pancreas/comprendre-la-maladie/l-essentiel.
