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Lower Antibody Response to Vaccinations Found in Individuals with Serious Psychiatric Disorders
Amsterdam, Netherlands – People diagnosed with severe psychiatric disorders, such as schizophrenia and bipolar disorder, exhibit a substantially reduced antibody response following vaccination against diseases like influenza and COVID-19, according to new research published November 12, 2025, in teh NRC. The findings raise concerns about the effectiveness of vaccination programs within this vulnerable population and highlight the need for tailored strategies to ensure adequate protection.
The study, conducted by researchers at[researchinstitution-[researchinstitution-[researchinstitution-[researchinstitution-details not provided in source], analyzed antibody levels in individuals with and without serious mental illness after receiving standard vaccinations. Results showed that those with psychiatric disorders produced consistently lower levels of antibodies, potentially leaving them more susceptible to infection despite being vaccinated. This diminished response is believed to be linked to the underlying biological mechanisms of these disorders and the impact of psychiatric medications on the immune system. Approximately 1-2% of the adult population experiences schizophrenia, and around 1% experiences bipolar disorder, meaning a significant number of individuals could be affected by this reduced vaccine efficacy. Further research is underway to determine optimal vaccination schedules and potential booster strategies for this group,and also to investigate the specific immunological factors contributing to the weaker response.
