“Anti-Aging Hormone” Klotho: Kidney–Brain Protein Linked to longevity, Boosted by Exercise & Diet, Says Expert
Madrid, Spain – A protein primarily produced in the kidneys and brain, known as Klotho, is emerging as a critical factor in healthy aging, according to nephrologist Borja quiroga.Research indicates declining Klotho levels accelerate age-related decline, increasing oxidative stress, inflammation, and impacting kidney function, Quiroga explained in recent interviews.
discovered in the late 1990s,Klotho’s importance was first highlighted by studies showing mice genetically deficient in the gene aged prematurely. The protein’s influence extends beyond kidney health, impacting vitamin D metabolism, cardiovascular function, neuronal protection, and insulin sensitivity.
“When Klotho levels decrease, oxidative stress, inflammation and deterioration of phosphocalcium metabolism increase, factors associated with the loss of kidney function and systemic aging,” Quiroga stated.
Crucially, individuals have agency in influencing their Klotho production. quiroga emphasizes that regular physical activity – aiming for 90 to 150 minutes of cardio exercise weekly, plus 7-10 minutes of isometric strength training – can regenerate Klotho levels. He also highlighted the detrimental impact of ultra-processed foods, stating, “The person who eats a lot of ultra-processed food will age much more than the person who does not consume it.”
An anti-inflammatory diet rich in fruits, vegetables, and omega-3 fatty acids, coupled with adequate rest, are also key to maintaining Klotho expression. While specific drugs to directly enhance Klotho production are still under progress, researchers are exploring therapies that mimic its effects.
Quiroga believes a deeper understanding of Klotho modulation could revolutionize preventative medicine, shifting the focus towards not just extending lifespan, but improving quality of life in later years. “Understanding how to modulate the Klotho protein could open the door to a new type of preventive medicine,” he concluded.
