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The trajectory for GLP-1s in addiction treatment is currently marked by ongoing studies and potential regulatory obstacles. Caron‘s initiative, for instance, faces an uncertain future. This program was initially funded by a grant from the Center for Addiction,Science,Policy,and Research,an advocacy organization established in 2024 that has dedicated its first year to promoting broader availability of GLP-1s for addiction therapy. However, the program’s sustainability hinges on Caron’s capacity to procure affordable, compounded semaglutide. As of now, no GLP-1 medication has received official approval for use as an addiction treatment. Insurers have not committed to covering the high cost of brand-name GLP-1s for addiction, and many are even reducing their reimbursement for these medications when prescribed for weight management.
Moreover, caron’s access to compounded versions may soon be curtailed due to a Food and Drug Administration ruling that is expected to prohibit compounding pharmacies from continuing their production.
Dr. klein is already exploring potential solutions. A limited number of compounding pharmacies, for example, have obtained licenses to produce semaglutide with a 12-month shelf life, extending supply into 2026. Additionally, generic versions of these medications could become available in Canada next year.
Beyond the outcomes of Caron’s pilot program, important questions remain regarding the efficacy of GLP-1s as addiction treatments, especially for the average individual who cannot afford care at a facility like Caron. The willingness of pharmaceutical companies to market these drugs for addiction, along with patients’ ability to access and tolerate them, are also key factors yet to be steadfast.
According to Dr. Sarhan, two aspects are already evident: ther is considerable patient interest in GLP-1s, and these medications are yielding unprecedented results.
“GLP-1 medications are universally more appealing to patients: they are novel, they are trendy, they facilitate weight loss, and they initiate a journey toward improved well-being,” he stated.
He further commented, “I have never had a patient initiated on naltrexone report that their cravings have been fully eliminated,” referring to a common treatment for alcohol and opioid addiction. “Conversely, I have received such feedback from individuals who have begun taking GLP-1 medications.”
STAT’s reporting on chronic health conditions is made possible by a grant from Bloomberg Philanthropies.Our financial supporters do not influence our editorial decisions.
