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Weight Loss Jabs Under Scrutiny for Potential Pancreatitis Risk
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A new study is underway to investigate potential links between popular weight loss jabs, such as Ozempic and Wegovy, and serious side effects, notably pancreatitis. The Medicines and healthcare Regulatory Agency (MHRA) and Genomics England are collaborating to determine if certain individuals are genetically predisposed to adverse reactions from these medications.
Study Launched Amid Rising Concerns
The investigation follows hundreds of reports of acute and chronic pancreatitis in individuals using weight loss drugs [[3]]. While a direct causal link hasn’t been definitively established, the MHRA and genomics England aim to identify those most at risk to ensure safer prescribing practices.
Did you Know? Adverse drug reactions could cost the NHS more than £2.2 billion a year in hospital stays alone.
Dr. Alison Cave, the MHRA’s chief safety officer, emphasized that the study’s findings will help predict which patients are most susceptible to adverse reactions, enabling more personalized and safer treatment plans. The study leverages the MHRA’s Yellow Card scheme, which allows anyone to report issues with medicines, vaccines, or medical devices.
How to Participate in the Study
Patients aged 18 and over who have experienced adverse reactions to weight loss jabs, also licensed for type 2 diabetes, are encouraged to report their experiences on the Yellow Card website. Participants may then be asked to provide additional information and a saliva sample for genetic analysis.
Pro Tip: Reporting any adverse drug reactions, even if you’re unsure if they’re related, can contribute valuable data to ongoing safety investigations.
Data collected through the Yellow Card scheme up to may 13 of this year included 10 cases of fatalities among weight loss drug users due to pancreatitis-related effects, although it remains unclear whether other factors contributed [[1]].
The Genetic Component
Professor Matt Brown, chief scientific officer at Genomics England, highlighted the potential to minimize adverse reactions through a better understanding of their genetic causes. He envisions a future where personalized prescription approaches lead to safer and more effective treatments.
The study aims to generate data that supports a shift towards a more prevention-focused healthcare system, where genetic information informs treatment decisions.
