Podcast Explores Essential Vitamins B1 and B2
A new episode of Wirkstoffradio (Active Ingredient Radio) delves into the crucial roles of vitamins, wiht a specific focus on thiamine (vitamin B1) and riboflavin (vitamin B2). Hosts Hans-Dieter Höltje and Bernd Rupp begin with a broad overview of vitamin functions and their categorization as either water- or fat-soluble.
The discussion than centers on thiamine, where Höltje provides a detailed explanation of the pyruvate dehydrogenase complex – outlining its three key steps and highlighting thiamine’s vital function within its active center.he illustrates how pyruvate is transformed into an acetyl residue, later transferred to lipoic acid, and ultimately to coenzyme A.
The podcast also examines riboflavin, detailing its role as a component of FAD and FADH within the body. Höltje and Rupp explain the changes occurring within the molecule’s mesomeric system during reduction reactions. the episode includes a visual explanation of the rearrangement of thiamine pyrophosphate (TPP) to a carbanion, illustrating proton transfers and shifts in the pyrimidine ring’s mesomeric system, as sourced from Hans-dieter Höltje.
