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Home » toxicology; toxicity; poisoning; toxins » Page 2
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toxicology; toxicity; poisoning; toxins

Health

Think Glass Bottles Are Safer? Think Again

by Dr. Michael Lee – Health Editor July 5, 2025
written by Dr. Michael Lee – Health Editor

Key Takeaways

Table of Contents

  • Key Takeaways
  • Health Risks
  • Contamination Levels
  • Glass Bottles

• A study by the French Agency for Food, Environmental and Occupational Health & Safety (ANSES) measured microplastics (MPs) in various beverages sold in France.

• Contamination was found in all drinks, including those in glass bottles.

• Without toxicological data, the health risks associated with the consumption of MPs remain unclear.

Since the 1950s, plastic production has soared, and single-use plastics have driven pollution in both terrestrial and aquatic environments. As they degrade, they form micro- and nano-plastics that permeate every ecosystem — from 10,000 m beneath the ocean surface to Himalayan glaciers and even clouds.

A French national study by the MICROSOF project — led by National Research Institute for Agriculture, Food and Environment and Institute for Research in Materials — found MPs in 75% of soil samples across 33 sites. The findings highlight the widespread presence of MP pollution in French soils and its potential risks to ecosystems and agriculture.

Health Risks

Although quantifying MPs in the environment and human samples is challenging, micro- and nano-plastics can penetrate organs of exposure, such as the lungs, colon, and skin, and reach distant organs, such as the testes, placenta, kidneys, and brain.

A report by the Parliamentary Office for Scientific and Technological Assessment stated that 0.5% of the brain mass is made up of plastic. Moreover, the number of MPs in the lungs increases with age, suggesting long-term persistence in the body. Data indicate that MP exposure may increase the risk for conditions such as stomach cancer, myocardial infarction, and stroke. Their toxicity is also linked to the chemical substances they contain or can absorb from the environment; over 4000 are classified as hazardous to human health.

Contamination Levels

Humans primarily ingest MPs through contaminated food and drinks. Numerous studies have noted the presence of MPs in bottled and tap water and in certain foods, such as vegetables, fruits, meat, eggs, tea, and rice.

ANSES researchers recently measured MP counts in bottled water, soft drinks, iced teas, lemonades, beers, and wines. They detected MPs measuring 30 μm to 500 μm in every beverage, with levels varying by beverage type.

Bottled water showed relatively low concentrations (2.9 MPs/L compared to the results already published in the literature. Sodas and lemonades registered 31.4 MPs/L and 101.5MPs/L, respectively; iced teas, 14.6 MPs/L; and beer, 84 MPs/L, with no notable difference between the varied brands evaluated. Wine in glass bottles averaged 12.0 MPs/L, although other studies have reported higher levels. The authors caution that comparing studies is challenging given the variations in standards, the variability in the size of the particles considered, the samples, and the volumes taken.

Glass Bottles

Beverages in glass bottles contained higher levels of MPs than those in plastic bottles or cans. The MPs matched the colour and polymer composition of the cap materials, suggesting that cap abrasion during large-scale storage drives contamination. Washing caps before sealing can significantly reduce MP levels. Within the glass bottle category, only wine stands out because of the use of cork stoppers.

This story was translated from Univadis France.

July 5, 2025 0 comments
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Health

Nuclear Emergency Drug: New Usage Guidelines Released

by Dr. Michael Lee – Health Editor June 20, 2025
written by Dr. Michael Lee – Health Editor

Imreplys Recommended for Hematopoietic Acute Radiation Syndrome treatment by EMA Committee

Table of Contents

  • Imreplys Recommended for Hematopoietic Acute Radiation Syndrome treatment by EMA Committee
    • Understanding Hematopoietic Acute Radiation Syndrome (H-ARS)
    • How Imreplys Works
    • Imreplys Indication and Prior Use
    • Exceptional Circumstances Authorization
      • Clinical Trial Results
    • Potential Side Effects
    • Usage Recommendations
    • Key Data on Imreplys
    • The Broader Context of Radiation Exposure and Treatment
    • Frequently Asked Questions About Radiation and H-ARS

The european Medicines Agency’s (EMA) Committee for Medicinal Products for Human Use (CHMP) has issued a positive recommendation for Imreplys, a drug designed to treat Hematopoietic Acute Radiation Syndrome (H-ARS) following acute exposure to myelosuppressive doses of radiation. This decision marks a significant step forward in addressing the life-threatening consequences of radiation exposure, especially in emergency scenarios.

Understanding Hematopoietic Acute Radiation Syndrome (H-ARS)

H-ARS arises when radiation suppresses bone marrow hematopoiesis, leading to a compromised immune system and increased susceptibility to infections and bleeding. This condition typically manifests after exposure to ample whole-body radiation doses, frequently enough in the range of 1 to 6 Gray (Gy), frequently associated with radiological or nuclear emergencies. Radiation is the emission of energy as electromagnetic waves or moving subatomic particles [[3]].

Did You Know? The average person is exposed to approximately 2.4 mSv of ionizing radiation annually from natural environmental sources [[1]].

How Imreplys Works

Imreplys contains sargramostim, a granulocyte-macrophage colony-stimulating factor, which counteracts H-ARS by stimulating the bone marrow to produce essential immune cells.These include granulocytes, macrophages, monocytes, red blood cells, and platelets, all crucial for fighting infection and maintaining overall health.

Imreplys Indication and Prior Use

The CHMP’s positive opinion indicates that Imreplys is now intended for use in patients of all ages who are suffering from H-ARS following acute exposure to myelosuppressive doses of radiation. Notably, Imreplys has also been utilized in the United States for patients aged two years and older to prevent serious infections in conditions such as leukemia, bone marrow transplants, and pre-chemotherapy blood cell collection.

Exceptional Circumstances Authorization

The authorization of Imreplys falls under “exceptional circumstances,” a regulatory pathway employed when comprehensive data on a medicine’s efficacy and safety are limited.This may occur due to the rarity of the condition, limited scientific knowledge, or ethical considerations that preclude extensive data gathering. Exceptional circumstances authorizations are subject to annual review.

Clinical Trial Results

The CHMP’s recommendation was supported by three randomized, blinded, placebo-controlled studies involving rhesus monkeys exposed to H-ARS-inducing total body irradiation. These studies demonstrated that Imreplys substantially increased 60-day survival rates compared to placebo. Furthermore, the studies revealed faster recovery of absolute neutrophil counts and platelets, reduced infection rates, and fewer instances of sepsis.

Potential Side Effects

As with any medication, imreplys may cause side effects. The most commonly reported side effects include fever, diarrhea, vomiting, skin reactions, rash, asthenia, metabolic laboratory abnormalities, malaise, high glucose levels, abdominal pain, weight loss, low albumin levels, pruritus, gastrointestinal hemorrhage, chills, pharyngitis, bone pain, chest pain, hypomagnesemia, hematemesis, arthralgia, anxiety, and eye hemorrhage.

Usage Recommendations

The EMA has stated that Imreplys will be available as a 250 μg powder for solution for injection and should be administered in accordance with official radiologic/nuclear emergency recommendations.

Pro Tip: Always consult the Summary of Product Characteristics (SmPC) on the EMA website for detailed usage guidelines in all official European Union languages after the European Commission grants marketing authorization.

Key Data on Imreplys

characteristic Details
Active Ingredient Sargramostim
Manufacturer Partner Therapeutics ltd
Indication Treatment of H-ARS following acute exposure to myelosuppressive doses of radiation
Dosage Form 250 μg powder for solution for injection

The Broader Context of Radiation Exposure and Treatment

While H-ARS represents a severe consequence of acute radiation exposure,it’s significant to remember that we are all constantly exposed to low levels of natural radiation from sources like soil,water,and even the air we breathe. Understanding the risks and potential treatments for radiation-related illnesses is crucial for public health preparedness.

Frequently Asked Questions About Radiation and H-ARS

What are the long-term effects of radiation exposure?
long-term effects can vary depending on the dose and type of radiation, but may include an increased risk of cancer and other health problems.
How can I protect myself from radiation exposure?
Minimizing exposure time, increasing distance from the source, and using shielding are effective ways to reduce radiation exposure.

Disclaimer: This article provides information for general knowledge and awareness only. It does not constitute medical advice. Always consult with a qualified healthcare professional for diagnosis and treatment of any medical condition.

What are your thoughts on the availability of treatments like Imreplys? How can communities better prepare for potential radiation emergencies?

Share your insights and join the conversation below!

June 20, 2025 0 comments
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Health

Heat, Poor Air Quality Ups Heart Attack Risk

by Dr. Michael Lee – Health Editor June 18, 2025
written by Dr. Michael Lee – Health Editor

Heat, Ozone Combo Hikes Heart Attack Risk

Study: Environmental Duo Threatens Cardiovascular Health, Especially for Women and Younger Adults

A new study reveals that simultaneous exposure to ozone pollution and high temperatures elevates the risk of acute myocardial infarction (MI) for adults within the United States. The research highlights the dangers of these combined environmental stressors, even at moderate levels, underlining the need for timely patient counseling to mitigate cardiovascular risks.

Joint Exposure Findings

Researchers from Yale School of Public Health, led by Lingzhi Chu, discovered that a combination of ground-level ozone (60 ppb) and temperatures around 90-95°F increased the risk of a heart attack by 33% compared to cooler, low-ozone days. Even with moderate conditions, such as ozone levels at 50 ppb and temperatures at 70°F, the risk increased by 15%.

“The lag of effect means clinicians need to pay close attention to high-pollution and hot days in real time,” stated Lingzhi Chu. “Clinicians should emphasize to younger patients that moderate levels still pose risks” to cardiovascular health.

“This study is important because it focuses on a younger age group that is often overlooked in cardiovascular research,”

—Mary Johnson, Research Scientist

The study indicates women are more vulnerable on days with both high ozone and high temperatures, while men experience heightened risks when either factor is elevated. These exposure-response pattern differences by sex were statistically significant (P = .016).

Prevention and Guidance

Chu recommends prevention strategies clinicians can share with patients, including adjusting outdoor activity timing, staying hydrated, and using cooling methods like fans or air conditioning. She suggests framing mitigation as simple behavior changes rather than dramatic life alterations to avoid overwhelming patients. The American Heart Association reports approximately 800,000 heart attack cases each year in the US.

Johnson, from the Harvard T.H. Chan School of Public Health, agrees with the findings. She highlights that clinicians need to understand the role of environmental factors in cardiovascular health.

“Just because you’re young and healthy does not necessarily rule out the risk of a cardiac event,” she said. “Especially if there’s a combination of poor air quality and elevated temperature.”

June 18, 2025 0 comments
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