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side effects

The Adverse Effects of Drinking Excessive Young Coconut Water: Side Effects and Risks Revealed

by Chief editor of world-today-news.com August 16, 2023

written by Chief editor of world-today-news.com

There are several side effects of drinking too much young coconut water. Even though it is known as a miracle drink, drinking too much coconut water can cause bad effects. Photos/Getty Images

JAKARTA – There are some side effects of drinking young coconut water excessive. Even though it is known as a refreshing miracle drink, drinking too much coconut water can cause adverse health effects.

Dietitian and nutritionist Melissa Hooper says that the extra calories from sugar are young coconut water can contribute to weight gain. Because it’s important to balance it with other foods and drinks consumed throughout the day.

The natural sugar content of young coconut water can also cause dental caries if you don’t diligently brush your teeth every day. Also, if you have diabetes, drinking coconut water in excess can lead to high blood sugar levels.

Most Side Effects of Drinking Young Coconut Water

Following are the side effects of drinking too much young coconut water, reported by Stylecraze, Wednesday (16/8/2023).

SINDOnews Photo/Infographic

1. Diarrhea

2023-08-16 12:15:00
#Side #Effects #Drinking #Young #Coconut #Water #High #Blood #Sugar

August 16, 2023 0 comments

Health

Tips for Managing Type 2 Diabetes Medications

by Chief editor of world-today-news.com July 20, 2023

written by Chief editor of world-today-news.com

Written by Nahir Abdel Nabi Wednesday, July 19, 2023 03:00 AM Submitted Type 2 diabetes medications Many options to help manage your blood sugar (also known as blood glucose) and your condition. But sometimes a medication doesn’t do its job, causes troublesome side effects, or doesn’t mix well with other medications you take.

According to webmd, if your treatment isn’t working well enough or you don’t feel it’s right for you, talk to your doctor. They may tell you it’s time to change your treatment plan.

Your doctor may need to change your medication, dose, or other aspects of your treatment if you often have:

-High blood sugar

It is important to keep your blood sugar in a healthy range. This reduces the chances of complications and helps you manage other conditions that come with diabetes. If your glucose readings are trending too high with your current medications, your doctor can change your dose or add another medication.

This can happen even if your medication worked well at first sometimes it just doesn’t do the trick on its own anymore.

If one medication does not control your blood sugar well enough, your doctor may add another medication. If two don’t work, they can add a third.

Low blood sugar

Sometimes diabetes medications can drop your blood glucose level too low. That can make you feel shaky, sweaty, dizzy, and confused. Your doctor calls this hypoglycemia, and it can be dangerous.

If this happens often, your doctor may need to lower your dose or change your medication.

Side effects of diabetes medications

It may also be time to change your diabetes medication if it is causing side effects that interfere with your life, or if it interacts with other medications you are taking.

Keep in mind that some side effects are temporary as your body gets used to a new medication. Talk to your doctor if you have serious side effects or if they don’t go away. They can tell you the best way to deal with them.

Different types of diabetes medications work in different ways, each with their own potential side effects and ways they can interact with other medications you take. Always make sure your doctor knows about any medications you take.

When you take these medicines, you could have:

nausea

Gas

bloating

Diarrhea or upset stomach

Vitamin B12 deficiency

These problems are usually temporary. Taking the medication with food can help.

It’s rare, but metformin can cause a serious condition called lactic acidosis. This happens when too much lactic acid (a chemical your body makes when it breaks down carbohydrates) builds up in your bloodstream. Call your doctor right away if you develop any of these symptoms:

Unusual weakness or tiredness

-difficulty breathing

Abnormal muscle pain

Sudden stomach problems, such as vomiting or diarrhea

-Anorexia

2023-07-19 00:00:00

#change #diabetes #medication

July 20, 2023 0 comments

Health

Frexalimab Shows Strikingly Positive Results in Treatment of Relapsing Multiple Sclerosis

by Chief editor of world-today-news.com June 9, 2023

written by Chief editor of world-today-news.com

Frexalimab, a second-generation anti-CD40L antibody, has shown “strikingly positive” effects in treating relapsing multiple sclerosis (MS), significantly reducing disease activity without depleting B cells. The drug is a novel, second-generation monoclonal antibody designed to block the costimulatory CD40/CD40L cellular pathway, the mechanism of which is believed to potentially modify T-and B-cell activation and innate immune cell function. In a phase 2, multicenter trial, 129 participants with relapsing MS were randomly assigned to one of four groups – high-dose frexalimab (n = 52), low-dose frexalimab (n = 51), or placebo (n = 12 high-dose, n = 14 low-dose) for the 12-week placebo-controlled period. Those receiving high-dose frexalimab had an 89% greater reduction in the number of new gadolinium-enhancing T1-lesions compared with the pooled placebo group after 12 weeks. Furthermore, after 24 weeks, 96% of the high-dose frexalimab group were free of gadolinium-enhanced T1 lesions.

Gavin Giovannoni, MD, PhD, chair of neurology at the Blizard Institute of Barts and the London School of Medicine and Dentistry in the United Kingdom, said these results were “better than expected” and have helped “fundamentally tackle autoimmunity”. He also added that it will be interesting to see if this treatment re-establishes immune tolerance and induces long-term remission. In his newsletter, Giovannoni characterized the study’s results as “strikingly positive,” adding that they “are the most exciting to emerge in MS in the last 12-24 months.”

Salim Chahin, MD, assistant professor of Neurology at Washington University in St. Louis, Missouri, commented that frexalimab represents an intriguing mechanistic approach to MS, “In the world of MS and neuroimmunology, this is indeed a unique mechanism that has not been explored before.” He noted that therapies targeting CD40 and CD40L are not new but were previously associated with unfavorable side effects, mainly thromboembolic events that halted their development. The drug appears to avoid these side effects, providing good phase 2 efficacy data. Additionally, the study found frexalimab to be well-tolerated over the 12-week study, with headache and COVID-19 reported among 4% or fewer participants and no serious adverse events were reported.

However, it remains to be seen whether the drug will be associated with a more favorable safety profile than some of the currently approved MS treatments, and further safety and efficacy issues will be watched closely in the phase 3 trial data. Despite this, the investigators note that this drug has the potential for further development as a high-efficacy therapy that can prevent inflammation in MS.

In summary, the potential of frexalimab in treating relapsing multiple sclerosis is significant, and the drug has demonstrated impressive results in its reduction of gadolinium-enhanced T1 lesions compared to the placebo. Given these results, the importance of developing a drug with limited side effects that can support MS patients is more critical than ever. The study paves the way for the development of new therapies that can control MS effectively.

June 9, 2023 0 comments

Health

“Yellow Fever Vaccine: Safety, Risks, and Side Effects”

by Chief editor of world-today-news.com April 26, 2023

written by Chief editor of world-today-news.com

Is the yellow fever vaccine safe?

Like all vaccines, this one also has its risks and side effects or adverse, however, studies reveal that the vaccine is 90% effective after 10 days of your application and and 99% safe after 30 days. Keep in mind that this vaccine is a single dose for your lifetime.

Between the minor problems that can present after its application are presenting fever, headache, general discomfort, swelling and redness at the application site. Generally, these symptoms are presented by 1 in 4 people who have been vaccinated and manifest shortly after its application. This is how the ‘mediline plus’ portal reports it.

You can see: Colon and rectal cancer is on the rise in Colombia

On the other hand, the serious problems that can occur are: having a allergic reaction to one of the components of the vaccine, it usually happens to 1 person in 55,000. Serious nervous system reactions can also occur, a case that occurs in 1 person in 125,000. In the most serious case of all, organ failure can occur, however, this occurs in 1 person in 250,000.

If no allergic reaction has occurred, the patient could apply a booster dose in the future.

2023-04-25 23:41:08
#Yellow #fever #vaccine #apply

April 26, 2023 0 comments

Health

The Truth About Algipan: Effectiveness and Safety Concerns

by Chief editor of world-today-news.com April 14, 2023

written by Chief editor of world-today-news.com

Warming ointments such as Algipan are used against muscle pain, cramps, bruises or sprains. Athletes like to use such ointments before or after exercise, to warm up stiff muscles or to relieve muscle pain.

But does Algipan deliver what it promises? Unfortunately there is no convincing scientific evidence that such a muscle ointment really helps with acute or chronic muscle or joint pain. In addition, Algipan contains several active ingredients that security risks content, which is why we advise against it.

What helps against muscle pain?

What is Algipan and what is it used for?

According to the manufacturer, Algipan Balm is indicated for muscle and joint pain: it is said to provide relief from muscle and ligament pain or painful contractures (shortening of muscle tissue): post-traumatic pain (pain after an accident), osteoarthritis, muscle pain, ligament pain, stiff neck and lumbago (lower back pain).

Algipan has the status of a medicinal product and is available in pharmacies without a prescription.

Ingredients and Mechanisms of Action of Algipan

Warming ointments all work on the same principle: they contain substances that locally irritate or irritate the skin. In English this is called a counterirritant. Often it concerns herbal and plant extracts.

The active ingredients of Algipan are glycol salicylate, mephenesin and methyl nicotinate. Glycol salicylate and methyl nicotinate are counterirritantsmephenisine is said to have a muscle relaxant effect.

Effectiveness of Algipan

Our research: does Algipan really work?

By locally irritating the skin, our brain is tricked in two ways: on the one hand, that irritation distracts our brain from the actual pain, on the other hand, it gives a false sensation of heat or cold.

Algipan therefore does not really heat the muscles or joints: it only sends stimuli of heat or cold to our brain, which drown out the pain signal. The effect is the same as when you bump your knee and rub it, where the stimuli of the friction (partially) drown out the pain stimuli.

In addition, the blood vessels at the level of the skin expand, so that more blood flows temporarily through the upper layers of the skin. That explains why the skin often turns red and swells when you apply the cream. However, this better blood flow remains very superficial and does not touch the deeper muscles, tendons or joints. In these deeper tissues there is no temperature rise.

Side effects of Algipan

Not only is there no convincing scientific evidence that Algipan actually helps with acute or chronic muscle or joint pain, the balm also contains a combination of ingredients that may have nasty side effects. side effects can provoke.

Risks of mephenesin in Algipan: allergic reactions

Algipan contains mephenesin which may cause serious skin conditions or local allergic reactions. In addition, it contains the substances methyl parahydroxybenzoate and propyl parahydrobenzoate, which can also cause allergic reactions and change the taste of breast milk.

Risks of glycol salicylate in Algipan: symptoms of poisoning when ingested or overdose

Algipan is for external use only. If the product is accidentally ingested, glycol salicylate can cause poisoning symptoms, especially in small children. These symptoms are fainting, profuse sweating, nausea, vomiting, confusion, fever, increased or deepened breathing (hyperventilation).

In severe cases, ingestion can lead to central nervous system and circulatory problems, as well as respiratory arrest. Therefore always keep this product out of the reach of children.

If someone has used too much Algipan or swallowed the product, contact your doctor, a pharmacist or the pharmacist immediately Antigifcentrum (070 245 245).

Our conclusion: Algipan is not recommended

Not only is there no convincing clinical evidence that Algipan helps with acute or chronic muscle or joint pain, it also contains several active ingredients that pose safety concerns.

Advice on the use of Algipan

If you still want to use Algipan, take the following precautions:

Do not use Algipan without a doctor’s advice if you are pregnant or breastfeeding.
Algipan is not suitable for small children. Also, always keep it out of their reach.
Test the balm on a small area of skin before first use. After all, there is a real chance that you will have an allergic reaction to one or more ingredients.
Wash your hands after each use.
Do not apply Algipan under a bandage or on skin that has already been heated in other ways, as this increases the risk of burns.
Avoid contact with eyes or mucous membranes such as mouth, nostrils or genitals.
Also do not apply to wounds, or to damaged or irritated skin (e.g. insect bites).

Alternatives to Algipan

We also took a closer look at the effectiveness and possible risks of Dexsil Sport joints and muscles, Flexicream, Rado Stick, Reflexspray and tiger balm.

Are these products better than Algipan?

To be on the safe side, check our overview before purchasing such a product, and find out which other analgesics you can safely use against muscle and joint pain.

April 14, 2023 0 comments

Health

A review has shown electroconvulsive therapy to have a small advantage over ketamine in improving depressive symptoms in adults with a major depressive episode, but the therapeutic advantage may be smaller than was previously thought. The study suggests ketamine should be tried before ECT for such patients. However, the small size and number of existing trials limits the main recommendation. Experts highlighted a need for more comparative studies with adequate sample size to answer clinically relevant questions about these treatments, which both help some patients with treatment-resistant depression.

by Chief editor of world-today-news.com April 12, 2023

written by Chief editor of world-today-news.com

Major depressive disorder is a debilitating mental illness that affects millions of people worldwide. Despite the availability of various treatment options, a significant proportion of patients do not respond to traditional antidepressants. This has led researchers to explore alternative therapies such as electroconvulsive therapy (ECT) and ketamine. Recently, new data has emerged comparing the efficacy and safety of these two treatments for major depressive disorder. In this article, we will review the latest evidence and explore the pros and cons of ECT and ketamine for the management of this challenging condition.

A meta-analysis has shown that electroconvulsive therapy (ECT) appears to have a slight advantage over ketamine for improving depressive symptoms in adults with a major depressive episode (MDE). The analysis included five trials with 278 adults with MDE. In the main analysis, posttreatment depression ratings showed a trend for lower scores with ECT compared with ketamine. However, the therapeutic advantage may be smaller than what was demonstrated in prior analyses. The study supports a recommendation for a trial of ketamine before ECT for patients with MDE, but this recommendation is limited by the small size and number of existing trials. In terms of cognitive outcomes, there were no significant between-group differences. However, ECT was superior to ketamine in terms of response rates and remission rates. A key limitation of the analysis is the small number of studies with limited sample sizes and a high risk of bias in all trials. The study was published in JAMA Psychiatry.

Several experts offered perspective on the analysis. Rupert McShane, a psychiatrist at the University of Oxford, noted that ECT and ketamine are both “potent” treatments for depression and this meta-analysis shows that they are, “broadly speaking, equally as good as each other with perhaps a slight advantage for ECT.” Allan Young from King’s College London noted that both ketamine and ECT have been shown to help some patients with treatment-resistant depression. George Kirov from Cardiff University said while the study is conducted well, most of the evidence is coming from one large trial conducted in Sweden. He noted that the other studies add small numbers of patients and the dependence of the results on one single study is high.

In conclusion, the study establishes the superiority of ECT against an active comparator (ketamine), which is popular and accepted to be quite effective. However, there is a need for more comparative studies with adequate sample size in non-inferiority designs, examining a wider range of benefits and side effects, and followed up for longer durations, to answer clinically relevant questions about the nature and durability of observed benefits with ketamine. Clinicians may consider a trial of ketamine in patients with MDE for whom the administration of ECT is limited by restricted availability of the treatment, concerns about its cognitive adverse effects, negative patient attitudes, and other issues.

In conclusion, the debate over the best treatment for Major Depressive Disorder continues with the emergence of new data comparing Electroconvulsive Therapy (ECT) and Ketamine. While ECT remains a well-established and effective treatment, Ketamine offers a new option for patients who have not found relief with traditional antidepressants. However, further research is needed to fully understand the long-term effects of Ketamine, and patients should always discuss the potential benefits and risks with their healthcare provider. Ultimately, personalized treatment plans that consider the unique needs of each patient are crucial for achieving successful outcomes in the management of Major Depressive Disorder.

April 12, 2023 0 comments

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