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Gut-Brain Disorders Common in Children with Celiac Disease Despite Gluten-Free Diet
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A groundbreaking study reveals that disorders of gut-brain interaction (DGBI) are surprisingly common among children with celiac disease (ced), even when they diligently adhere to a gluten-free diet. The research, conducted at Cincinnati Children’s Hospital medical Center (CCHMC), highlights the importance of considering DGBI in pediatric CeD patients who continue to experience gastrointestinal issues despite proper disease management.
Prevalence of DGBI in Pediatric Celiac patients
the retrospective chart review, encompassing nearly 200 pediatric CeD patients, found that a significant 43% met the Rome IV diagnostic criteria for DGBI Rome IV diagnostic criteria. Functional constipation (33%) and functional abdominal pain (29%) were the most prevalent DGBI diagnoses within this cohort.
Did You No? DGBI, formerly known as functional gastrointestinal disorders, affect approximately one-third of adults and 25% of children aged 4-18 years.
Key findings on Risk Factors
The study identified several factors that increase the likelihood of developing DGBI in children with celiac disease. Presenting symptoms such as abdominal pain (OR, 3.09), constipation (OR, 2.19), vomiting (OR, 2.36),and nighttime pain awakening (OR,9.76) at the initial visit were significant predictors. Moreover, patients with complete villous blunting, a marker of severe intestinal damage, also faced an elevated risk (OR, 2.28).
Additional analysis revealed that comorbid conditions, including joint hypermobility syndrome (OR, 5.23), headaches (OR, 3.47), chronic musculoskeletal pain (OR, 3.20), chronic muscle pain (OR, 5.61),and any comorbid