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Semaglutide (Ozempic) Shows Promise in Improving Walking Distance for Type 2 Diabetes Patients with PAD
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Chicago, IL – New findings from a subanalysis of the STRIDE trial, presented at the American Diabetes Association (ADA) 2025 conference, indicate that semaglutide 1.0 mg (Ozempic) provides significant benefits for individuals with type 2 diabetes and peripheral artery disease (PAD). The research demonstrates significant improvements in walking distance, regardless of HbA1c levels or other diabetes treatments [1].
Semaglutide’s Impact on Peripheral Artery Disease
The STRIDE trial, a double-blind, randomized, placebo-controlled study, investigated the effects of semaglutide on walking distance in patients with type 2 diabetes and PAD. The study, which began in 2020, involved 792 patients across 20 countries who were randomly assigned to receive either semaglutide or a placebo for 52 weeks [2].
Did You Know? Peripheral artery disease affects over 200 million people worldwide, and those with diabetes are at a higher risk.
The primary endpoint of the trial focused on the ratio from baseline in maximum walking distance at 52 weeks. Results showed a significant advantage for semaglutide, with an estimated treatment ratio (ETR) of 1.13 (95% CI, 1.06-1.21; *P* = .0004). Secondary outcomes further supported these findings, including greater betterment in walking distance, significantly higher quality-of-life scores, and improved pain-free walking distance [3].
Key Findings Presented at ADA 2025
professor Subodh Verma, MD, PhD, a cardiovascular surgeon at the University of Toronto and senior author of the STRIDE trial, presented a subanalysis at ADA 2025, highlighting that semaglutide was associated with significantly improved walking outcomes, enhanced quality of life, and a 54% reduction in the risk of disease progression.The median ratio to baseline in maximum walking distance was 1.21 in the semaglutide group compared to 1.08 in the placebo group at week 52 [4].
Pro Tip: Regular monitoring of foot health is crucial for individuals with diabetes and PAD to prevent complications.
Efficacy data indicated that the positive effects of semaglutide were independent of baseline glycemic control, duration of diabetes, or intensity of diabetes treatment.The effects were also consistent across different BMI categories and irrespective of background SGLT2 inhibitor use.
Safety and Tolerability
Additional safety data from the STRIDE trial demonstrated that semaglutide was well-tolerated, with no treatment-related deaths and a safety profile consistent with prior data.This reinforces semaglutide as a safe and effective treatment option for this patient population