A traditional Chinese medicinal herb, Polygonum multiflorum, is gaining attention from scientists for its potential to treat hair loss, according to a new review of historical and clinical data.
For centuries, Polygonum multiflorum – known in China as Ho-shou-wu or He shou wu, and commonly referred to in English as tuber fleeceflower or Chinese knotweed – has been used in traditional medicine to combat premature graying and hair loss. Recent research suggests that these long-held beliefs may be supported by modern scientific evidence.
The findings are detailed in a review accepted for publication in the Journal of Holistic Integrative Pharmacy. Researchers, led by Han Bixian, examined ancient records dating back to the Tang Dynasty alongside modern clinical and laboratory studies.
“Our analysis bridges ancient wisdom and modern science,” Han stated. The team discovered that descriptions of the herb’s effects in historical texts “align perfectly with today’s understanding of hair biology.” Modern clinical data, they found, closely mirrored the historical writings regarding the herb’s uses.
Beyond addressing hair loss, Polygonum multiflorum also shows potential in restoring hair color at the onset of graying. The herb appears to function by blocking hormones linked to hair shrinkage, promoting blood flow to the scalp, and supporting natural hair regrowth processes. This multi-faceted approach distinguishes it from many currently prescribed hair loss medications, which often target only a single biological pathway.
Specifically, the herb appears to minimize the effects of dihydrotestosterone (DHT), a hormone known to contribute to hair follicle shrinkage. It also appears to protect hair follicles at a cellular level and extend their lifespan, potentially facilitating hair regeneration rather than simply slowing hair loss.
While further testing is needed to confirm its safety profile, Han suggests that existing data is promising, particularly when the herb is prepared using traditional methods. “When properly processed—a key step in traditional preparation—the herb shows a favorable safety profile, making it more acceptable to patients wary of side effects like sexual dysfunction or scalp irritation linked to current medications,” Han and his co-authors wrote in their review.
The research highlights the potential for integrating traditional knowledge into modern medical approaches. “Modern studies now confirm that this isn’t folklore; it’s pharmacology,” Han said.
The team’s review, titled “Research progress on the application of Pleuropterus multiflorus in the treatment of androgenetic alopecia,” builds on previous research into the plant’s medicinal properties. A separate study, published by Frontiers, investigated Polygonum multiflorum-Induced Liver Injury, examining clinical characteristics, risk factors, and potential mechanisms of action. That research underscores the need for careful consideration of potential side effects and proper preparation methods.