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“where buprenorphine was associated with enhanced physical health outcomes or at least no meaningful differences.Both methadone and buprenorphine can improve physical health by alleviating opioid cravings and withdrawal symptoms. After three years of treatment, buprenorphine demonstrated slight advantages concerning stomach cramps, fatigue, and feelings of coldness17. The reasons for discrepancies in QoL among opioid-dependent patients in our study in Iran compared to other countries remain unclear. However, it is plausible that methadone’s full agonist properties may provide more effective suppression of withdrawal symptoms and cravings, leading to improved physical functioning and fewer limitations compared to buprenorphine7. Additional factors, such as dosage, may contribute to these outcomes.
Regarding psychological health,no significant differences were observed between the treatment groups.”