Fish oil Omega-3s May Reduce Dementia and Alzheimer’s Risk, New Research Suggests
New York, NY – September 18, 2025 – A groundbreaking study published today in Neurology indicates a potential link between higher blood levels of omega-3 fatty acids, commonly found in fish oil supplements, and a reduced risk of developing dementia and Alzheimer’s disease. Researchers followed over 2,000 adults aged 65 and older for an average of five years, finding those with the highest concentrations of omega-3s in their blood exhibited a significantly lower incidence of cognitive decline.
The findings arrive as global populations age and the prevalence of dementia – currently affecting over 55 million people worldwide, according to the World Health Organization – continues to rise. Alzheimer’s disease, the most common form of dementia, poses a significant public health challenge, with projections estimating nearly 14 million Americans will be living with the disease by 2050. This research offers a potentially accessible and preventative strategy to mitigate risk, prompting further examination into optimal dosage and long-term effects of omega-3 supplementation.
The study, led by Dr. Michelle Mielke at the mayo Clinic, measured participants’ blood levels of three types of omega-3 fatty acids: EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), and ALA (alpha-linolenic acid). Results revealed that individuals in the top quartile for total omega-3 levels had a 30% lower risk of developing dementia compared to those in the lowest quartile. DHA, in particular, demonstrated a strong inverse association with Alzheimer’s disease.
“While we cannot definitively say that omega-3s prevent dementia,our findings suggest a strong correlation,” explained Dr. Mielke. “Increasing omega-3 intake through diet or supplementation may be a viable strategy to support brain health as we age.”
Participants’ cognitive function was assessed annually using a thorough battery of tests. Researchers controlled for other factors known to influence dementia risk, including age, genetics, education, and lifestyle habits. The study did not investigate why omega-3s might be protective, but theories include their anti-inflammatory properties and their role in maintaining the structural integrity of brain cell membranes.
Experts caution that more research is needed to confirm these findings and determine the optimal dosage of omega-3s for cognitive benefit. Current dietary guidelines recommend adults consume at least two servings of fatty fish per week, such as salmon, tuna, and mackerel. Individuals considering fish oil supplements should consult with their healthcare provider.