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(Taiwan English News / Zhu Mingzhu comprehensive foreign report) According to a study published in the journal “The Lancet”, researchers have found a particularly severe monkeypox (Mpox) virus in patients with advanced HIV, which not only has a higher fatality rate , and easily lead to serious complications.

Before April of last year (2022), monkeypox epidemic areas were mainly in West and Central Africa, but since the first local case appeared in the UK on May 7 last year, it has spread rapidly around the world, and the vast majority of infected people are people of the same sex Men who have sex, as of now, at least 110 countries have reported more than 86,000 confirmed cases and 93 deaths; 38-50% of these confirmed cases are also HIV-infected, but most of them are receiving anti-AIDS virus treated and in stable condition.

An international team of clinicians from 19 countries analyzed 382 cases of monkeypox and advanced HIV infection, including deaths at the peak of the epidemic, between May 11, 2022, and January 18, 2023. 27 people with monkeypox.

Researchers have identified a particularly severe form of monkeypox (Mpox) virus in patients with advanced HIV and named it “violent monkeypox virus”, which can cause severe symptoms such as extensive sores on the skin and genitals, and even death. Extensive necrotic lesions in the lungs; the most severe symptoms are usually seen in patients with the lowest counts of white blood cells called CD4 cells.

CD4 cells refer to T lymphocytes with CD4+ T molecules on the surface, which are important immune cells in the human immune system. The CD4 cell number index of normal people is about 800-1200 cells/mm3, but when the HIV virus enters the human body, it will It is carried to the whole body through the blood and destroys CD4 cells in the human immune system. According to the US Centers for Disease Control and Prevention (CDC), HIV infection is diagnosed when the CD4 count is below 200.

Epidemiologist Oriol Mitja called on health authorities to give priority to monkeypox vaccination for “people infected with HIV”, especially in countries where diagnosis and antiviral treatment are not widely available. Chloe Orkin, professor of clinical medicine at Queen Mary University of London, suggested that monkeypox patients should be tested for HIV, and if HIV-infected people are infected with monkeypox, CD4 values ​​must be tested.

Study: HIV-infected people found to be at higher risk of complications, death from violent monkeypox virus

(Taiwan English News / Zhu Mingzhu comprehensive foreign report) According to a study published in the journal “The Lancet”, researchers have found a particularly severe monkeypox (Mpox) virus in patients with advanced HIV, which not only has a higher fatality rate , and easily lead to serious complications.

Before April of last year (2022), monkeypox epidemic areas were mainly in West and Central Africa, but since the first local case appeared in the UK on May 7 last year, it has spread rapidly around the world, and the vast majority of infected people are people of the same sex Men who have sex, as of now, at least 110 countries have reported more than 86,000 confirmed cases and 93 deaths; 38-50% of these confirmed cases are also HIV-infected, but most of them are receiving anti-AIDS virus treated and in stable condition.

An international team of clinicians from 19 countries analyzed a total of 382 cases of monkeypox and late-stage HIV infection, including those who died at the peak of the epidemic, between May 11, 2022, and January 18, 2023. 27 people with monkeypox.

Researchers have identified a particularly severe form of monkeypox (Mpox) virus in patients with advanced HIV and named it “violent monkeypox virus”, which can cause severe symptoms such as extensive sores on the skin and genitals, and even death. Extensive necrotic lesions in the lungs; the most severe symptoms are usually seen in patients with the lowest counts of white blood cells called CD4 cells.

CD4 cells refer to T lymphocytes with CD4+ T molecules on the surface, which are important immune cells in the human immune system. The CD4 cell number index of normal people is about 800-1200 cells/mm3, but when the HIV virus enters the human body, it will It is carried to the whole body through the blood and destroys CD4 cells in the human immune system. According to the US Centers for Disease Control and Prevention (CDC), HIV infection is diagnosed when the CD4 count is below 200.

Epidemiologist Oriol Mitja called on health authorities to give priority to monkeypox vaccination for “people infected with HIV”, especially in countries where diagnosis and antiviral treatment are not widely available. Chloe Orkin, professor of clinical medicine at Queen Mary University of London, suggested that monkeypox patients should be tested for HIV, and if HIV-infected people are infected with monkeypox, CD4 values ​​must be tested.

Study: People with advanced HIV infection are at higher risk of complications, death from monkeypox

Rockville, MarylandFebruary 16, 2023 /PRNewswire/ — Tetracore, Inc. (Tetracore®) is pleased to announce a partnership with the United States Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) to provide Large supply of PCR kits. These kits were purchased for use in the National Animal Vaccines and Veterinary Countermeasures Library to ensure that the United States is prepared for a possible outbreak of severe exotic animal disease (FAD). As the only PCR kits authorized by the USDA for use with these diseases, Tetracore’s VetAlert African Swine Fever and Hand, Foot and Mouth Disease Diagnostic Tests are critical to minimizing the potentially devastating impact of exotic animal disease outbreaks.

The emergence of African swine fever in the Dominican Republic represents an imminent threat to the welfare of US food production. Outbreaks of hand, foot and mouth disease and African swine fever can have devastating economic consequences for the livestock industry. This threat requires readily available, accurate and validated diagnostics. The immediate surge of samples flooding animal health testing laboratories will quickly exhaust available countermeasures. To address the need for laboratory surge capacity in the event of an outbreak, the USDA has asked Tetracore to stockpile its USDA-authorized HFMD and ASF test kits.

The VetAlert ASF and HFMD Diagnostic Tests have been updated with modern viral sequences to ensure the tests remain fit for purpose. These assays have been validated in studies in multiple reference laboratories. The VetAlert™ African Swine Fever and Hand, Foot and Mouth Disease Diagnostic Assays were developed and commercially marketed by Tetracore scientists and are sold exclusively by Tetracore.

About Tetracore, Inc.

Tetracore is a biotechnology company that develops and manufactures diagnostic instruments and assays for the detection of infectious diseases. The company is located in the Biotechnology Corridor of Rockville, Maryland. Tetracore was founded in 1998 by former United Nations Special Commission biological weapons inspectors and scientists at the Naval Medical Research Institute in Bethesda, Maryland. For more information, please visit or send email to contact us.

®Tetracore is a registered trademark, and VetAlert yes Tetracore, Inc. the trademark of