‘Forever Chemicals’ Linked to Brain Harm

Study finds connection to anxiety and memory deficits, especially in males

Health experts are sounding the alarm regarding per- and polyfluoroalkyl substances (PFAS), also known as “forever chemicals.” Found in many everyday items, these chemicals are now increasingly associated with neurological harm, raising concerns about long-term health impacts.

Key Development

Research from the University of Rochester, published in the European Journal of Neuroscience, indicates that even short-chain PFAS variants, such as PFHxA, may significantly affect brain development. The study revealed that males are particularly susceptible, leading to anxiety and memory deficits.

The Rise of PFAS

Developed in the 1940s, PFAS gained popularity because of their resistance to heat, water, and oil. They became a staple in nonstick cookware, water-resistant clothing, cosmetics, dental floss, and fast-food wrappers. Data from the National Health and Nutrition Examination Survey (NHANES) showed that over 98% of the US population has detectable levels of PFAS in their blood (CDC Fact Sheet).

Brain Impact

The Rochester study found that early-life exposure to PfhxA may heighten anxiety and impair memory in male mice. “Although these effects were mild, finding behavioral effects only in males was reminiscent of the many neurodevelopmental disorders that are male-biased. This finding suggests that the male brain might be more vulnerable to environmental insults during neurodevelopment,” said Ania Majewska, PhD, professor of Neuroscience and senior author.

Lasting Consequences

Researchers tracked the mice into adulthood and found that PFHxA exposure affected behavior long after the exposure had ended. “This work points to the need for more research in short-chain PFAS. To our knowledge, PFHxA has not been evaluated for developmental neurobehavioral toxicity in a rodent model,” added Majewska.