The gut bacterium *Odoribacter*, particularly the species *Odoribacter splanchnicus*, is frequently observed in lower abundance during colonic inflammation, suggesting a potential role in preserving gut health and balance[[38, 39]. While *Odoribacter* levels rose in both mothers and their offspring, only the maternal group demonstrated a decreased susceptibility to colitis. This observation implies that the mere presence of *Odoribacter* might not be sufficient to confer protection. in contrast, a notable increase in *Desulfovibrio* was noted in the offspring. This genus has been associated with the pathology of inflammatory bowel disease (IBD)[[40, 41], potentially worsening inflammation and negating any protective effects inherited from the maternal microbiome. These findings highlight the intricate nature of host-microbiota interactions.
Though, several limitations of this study warrant consideration. The establishment of *E. multilocularis* infection within the peritoneal cavity led to a reduction in reproductive success among the infected mothers. This resulted in a limited number of offspring available for subsequent analysis, which may have impacted the sample size and diminished the statistical power of observations related to the offspring. Furthermore, while the study suggests a potential link between increased *Foxp3* expression, alterations in the microbiota, and reduced colitis severity in maternal mice, the precise molecular and cellular mechanisms underlying these effects remain not fully elucidated. Further investigation with additional markers is