FOR โIMMEDIATEโฃ RELEASE
Author Correction Published: Sirt1‘s Neuroprotective Role in Huntington’s โDisease Models Confirmed
A recent correction โฃhas been published regarding the article “Neuroprotective role of Sirt1 in mammalianโค models of Huntington’s disease through activation of multiple Sirt1 targets,” clarifying author affiliations and ensuring accuracy in attribution. Theโ study,originally detailing the neuroprotective effects of Sirt1 activation in Huntington’s disease (HD) models,involved collaborative research across multiple institutions.
Key researchers contributing to the work โขinclude Hyunkyung jeong and Dimitri Krainc from Harvard Medical School, Boston, Massachusetts; Tim West andโ David M Holtzmanโ fromโข Washington University School of Medicine, St. Louis, Missouri;โค Zhipeng Hou, jiangyang Zhang & Susumu Mori from Johns Hopkinsโข University School of Medicine, Baltimore, Maryland; Huan Caiโค & Bronwen Martin from the Metabolism Unit, Laboratory of Clinical Investigation, National โขInstitute โขon Aging (NIA), US National Institutes โฃof Health (NIH), Baltimore, Maryland; Tamaraโค Seredenina & Ruth Luthi-Carter from the Brain Mind Institute, Ecole โฃPolytechnique Fรฉdรฉraleโ de Lausanne, Lausanne, Switzerland; X William Yang from the University of California, Los Angeles, California; Kellie L Kโ Tamashiro &โค timothyโ H Moran from Johnsโฃ Hopkins University School of Medicine, Baltimore, Maryland; Just Susanโข from the Center for Metabolism and Obesity Research, โคjohnsโฃ Hopkins University โSchool of Medicine, Baltimore, โMaryland; Stuart maudsley & Mark P Mattson from the Laboratory of Neurosciences, NIA, NIH, Baltimore,โข Maryland; and Christopher A Ross andโ Wenzhen Duan from Johns Hopkins University School of Medicine, Baltimore, Maryland.
The research highlights the potential of targetingโ Sirt1, a protein involved โฃinโ regulating โcellular health, as a therapeuticโ strategy for Huntington’s disease, a fatal genetic disorder that causes the progressive breakdown of nerve cells in the brain. The study demonstrated that activating Sirt1โข in mammalianโข modelsโ led to the activation of multiple โคdownstream targets, resulting in neuroprotection.