Researchers have identified a key gene, COL6A3, that plays a important role in the recurrence and malignancy of meningiomas, a common type of brain tumor. The study, which utilized RNA sequencing and single-cell transcript analysis, tracked changes in tumor cells from primary cancer to recurrence.
The findings revealed that COL6A3 expression substantially increased in recurrent meningiomas, correlating with rapid cell growth. Further analysis indicated that COL6A3 becomes more active in the later stages of tumor progress.
Inter-cell signal transmission analysis highlighted that COL6A3 interacts with immunosuppressive macrophages, a mechanism that appears to promote tumor malignancy. This interaction suggests a potential pathway for the tumor to evade the immune system and progress.
“This study, based on single-cell transcript analysis of primary and recurrent meningiomas, elucidates how the tumor changes over time and interacts with its immune surroundings,” stated a representative from the research team.
The research findings have been published in the international journal Nature Communications,which has an impact factor of 15.7.
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