“Anti-Aging Hormone” โฃKlotho: โKidney–Brainโค Protein Linked โคto longevity, Boosted by Exercise & Diet, Says Expert
Madrid, Spain – A protein primarily produced in the kidneys and brain, known as Klotho, โขis emerging as a critical factor โin healthy โaging, according to nephrologist โBorja quiroga.Research indicates declining Klotho levels accelerate age-related decline, increasing oxidative stress, โคinflammation, and โขimpacting kidney function, Quiroga explained in recent โฃinterviews.
discovered in the late 1990s,Klotho’s importanceโ was first โขhighlighted by studies showing โmice genetically deficient in the gene aged prematurely. The protein’s influence โคextends beyond kidney health, impacting vitamin D metabolism, cardiovascular function, โคneuronal protection, andโฃ insulin sensitivity.
“When Klotho โlevels โdecrease, oxidative stress, inflammation andโค deteriorationโค of phosphocalcium metabolism increase, factors associated โwith the loss of kidney function andโ systemic aging,” Quiroga stated.
Crucially, individuals โคhave agencyโ in influencing their Klotho โขproduction. โคquiroga emphasizesโ thatโ regular physical activity – aiming for 90 to 150 minutes of cardio exercise weekly, plusโค 7-10 minutes of isometric strength training – can regenerate Klotho levels. He also highlighted the detrimental impact of ultra-processed foods, stating, “The person whoโ eats a lot of ultra-processed โขfood will age much more than the person whoโค does not consume it.”
Anโฃ anti-inflammatory diet rich in fruits, vegetables, and omega-3 fatty acids, โcoupled with โadequateโฃ rest, are also key to maintaining Klotho expression. Whileโ specific drugs to directly enhance โKlotho production are still under progress,โข researchers โare exploringโค therapies that mimic its effects.
Quiroga โขbelieves a deeper โunderstanding โof โคKlotho modulation could revolutionize preventativeโ medicine, shifting the focus towards not just extending lifespan, but improving โquality of life in laterโฃ years. โ “Understanding how to modulate the โขKlotho protein could open the doorโข to a new type of preventive medicine,” he concluded.