Paris, France – December 2, โข2025 – A groundbreaking study reveals a surprising dietary component-cabbage-may significantly enhanceโข the effectiveness of immunotherapy, โaโค leading cancer โtreatment. Research published in Natureโ Communications demonstrates that compounds found in cabbage โactivate โฃtheโข aryl Hydrocarbon Receptor (AHR),a crucial process for bolstering theโข body’s immune response to tumors.
The findings, released today byโฃ Inserm and โInstitut Curie,โ offer aโ potential,โค accessible strategy โฃto improve outcomesโข for patients undergoing anti-PD1โข therapy. Immunotherapy, while โคtransformative for many, doesn’t work for everyone, and identifyingโฃ factors that โขamplify its efficacy is a critical area of ongoing research. This discovery suggests aโ simple dietary โคadjustment could โbroaden theโฃ reach โฃand impact of these life-saving treatments, affecting millions diagnosed with cancer globally.
Lead by รlodie segura and colleagues at Institut Curie, the study pinpointed that physiological activation of the AHR โคbyโ ligands derived from food is essential for anti-PD1 therapy to succeed. Researchers, including Alice Coillard, Adeline cros, Alessandra Rigamonti, Lamine Alaoui, Julio L Sampaio, Natacha Monot, Aurรฉlie Balvay, anne Foussier, Mathildeโ Rieux-Laucat, Lรฉa โคGuyonnet, Sylvie Rabot, and Christian vosshenrich, detailed their work in a paper available via DOI:โข https://www.doi.org/10.1038/s41467-025-66854-x.โข
The press release from Insermโข and Institut Curie, embargoed until 11:00 a.m.CET on December 2, 2025, highlights โขthe potential ofโ cabbage as an “essential ally” inโ immunotherapy. โขFurtherโฃ research will focus on optimizing dietary recommendations and understanding the specific โcompounds within โcabbage responsible for AHR activation.
