heredity

Suspicion of PCOS in case of irregular menstruation, increased body hair and acne, male pattern baldness, and abdominal obesity
Two generations of male offspring cause obesity and metabolic disorders
There is no cure, but drugs and lasers can increase your chances of getting pregnant

A new study has found that diseases common in women of childbearing age are involved in obesity in male offspring. According to Cell Reports Medicine, an international medical journal, on the 5th, boys born to mothers with polycystic ovary syndrome (PCOS) are about three times more likely to be obese.

This study suggests that PCOS can be passed on to multiple generations through males and cause health problems, and has provided a new perspective on the identification of related symptoms and preventive treatment.

PCOS is a condition in which a small amount of testosterone in the ovaries is abnormally increased. Women with PCOS are more likely to experience irregular ovulation, acne, increased body hair, male pattern baldness, and difficulty conceiving. In addition, they have insulin resistance, so they tend to be obese, and obesity increases more testosterone, leading to a vicious cycle in which PCOS symptoms worsen.

The exact cause of PCOS is not known, but it is common for mothers, daughters, and sisters to have PCOS in families. However, it was not clear how PCOS affected male offspring (sons).

According to researchers at the Karolinska Institute in Stockholm, Sweden, PCOS in mothers is more likely to cause weight and hormonal problems in sons.

In this research paper, the researchers used registry data and a mouse model to confirm that similar traits of PCOS are passed on to their sons. More than 460,000 men born in Sweden between July 2006 and December 2015 were included in the study. Of these, about 9,000 were born to mothers with PCOS. The researchers confirmed obesity in all subjects.

Professor Elisabeth Stener-Victorin, who led the study, said: “We found that sons of women with polycystic ovarian syndrome had a three times higher risk of obesity and higher levels of bad cholesterol, which later increased their risk of developing insulin resistance and type 2 diabetes. did,” he said.

The researchers also tried to prove it through a mouse model. Female mice exposed to high-fat, high-calorie, androgen levels, and female mice bearing PCOS, and male mice from standard female mice, were fed a standard diet until adulthood, and their fat distribution and metabolism were investigated.

The results revealed that, despite being fed a healthy diet, male puppies of PCOS-bearing females had more adipose tissue, larger fat cells and impaired basal metabolism. These male mice were bred with healthy female mice and passed on the obesity factor to the second generation, only to lose the trait in the third generation.

“This experiment demonstrates that women’s obesity and high levels of testosterone during pregnancy can cause long-term health problems in their male offspring,” said Cao Lin Deng, one of the researchers. affects,” he said.

Unfortunately, there is no cure for PCOS yet, but symptoms can be improved. Laser treatment that destroys ovarian tissue that produces male hormones is sometimes applied to the use of medications for irregular ovulation cycles or infertility caused by PCOS. If you make an effort to find a balance in your body through weight loss, a balanced diet, and exercise, improvement is expected to be faster.

Professor Elisabeth Stener-Victorin said, “This study is important because it can help men’s generational genetic health problems to identify future reproductive and metabolic diseases early and find treatment and prevention options.”

Chemical News Reporter Park Chan-seo

Chemistry is everywhere. Copyright © Chemical News Unauthorized reproduction and redistribution prohibited