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Otsuka Receives Japanese Approval โfor Paradise Ultrasound System toโค Treatโ Resistant Hypertension
Published:โค August โค25, 2025
Source: world-today-news.com
Articleโ Section: Medical Devices, Cardiology
Backstory: Resistant hypertension, a condition โaffecting millions globally, poses a significant challenge โฃto healthcare systems. The Paradise ultrasound renal denervation system represents a perhaps groundbreaking non-pharmacological approach to managing this difficult-to-treat form ofโ high blood โpressure, offering hope to patients who haven’t responded to conventional therapies.
otsuka Medical Devices Co., โLtd. โคannounced โขtoday theโ receipt of manufacturing and โmarketing approvalโ in โขJapan for the โขParadiseโ ultrasound renal denervation (uRDN) system. this innovative system is designed to treat resistant hypertension – high blood pressure that remains uncontrolled despiteโ the use โofโ three or more different medications, including a diuretic.
The Paradise uRDN system was โขdeveloped by โRecor Medical, Inc., aโ U.S.-based subsidiary of โขOtsuka Medical Devices. the approval in โJapan is based onโค compelling โdata from the RADIANCE-HTNโ TRIO study, aโ rigorous randomized, sham-controlled clinical trial conducted across the United States and Europe.
Theโ RADIANCE-HTNโ TRIO study enrolled patientsโ alreadyโ receiving a standardized tripleโค antihypertensive therapy regimen.Results demonstrated a statistically significant andโ clinically meaningful reductionโค in daytime ambulatory โsystolic blood โคpressure atโฃ two months post-treatment with the Paradise โuRDN system. โImportantly, the system โexhibitedโ a consistently โขfavorable safety profileโ throughout the duration of the study.
Otsuka Medical Devices confirmed that a postmarketโ surveillance study willโค be conducted inโ Japan, adhering โคto โall local regulatory requirements. This ongoing monitoring will โprovide further insights into the โฃlong-term safetyโข and efficacy โof the Paradise system within the Japaneseโ population.
The paradiseโฃ uRDN system has already secured regulatory approvalsโ in key markets, including โฃthe United statesโข (FDA approval) and Europe โข(CEโข Mark approval). โTo ensure comprehensiveโ and long-term data collection, theโ GPS postmarket โregistry is actively enrolling patients in โthe European Union, United Kingdom, and United States, โwith plans for expansionโค to a โglobal scale.
“This approval marks a significant milestone in our commitment to providing innovative solutions โfor patients with resistant hypertension,” stated โฃa representativeโฃ from Otsuka Medical Devices.
“We โbelieve the Paradise system has the potential to transform the treatment landscape for this challenging condition.”
Renalโ denervation, the underlying โคprinciple of the Paradise system, involves using ultrasound โenergy to disrupt โคthe nerves surrounding the renal arteries. This disruption helps to โขregulate blood pressure by reducing sympathetic nervous system activity. Theโ Paradise system’s unique ultrasound-based approach aims to offer aโค precise and targetedโ treatment option.
Understanding Resistant Hypertension:โฃ Trends and Insights
Resistant hypertension is a growing โคglobal โhealth concern, frequently enough linked to factors like aging populations,โฃ increasing rates of obesity, and lifestyle factors. Current estimates suggestโข that 10-30% of hypertensive patientsโค experience resistanceโ to conventional therapies. The progress of novel treatment modalities,such asโ renalโข denervation,is crucial to address this unmet medical need.โค Future research will likely โขfocus on identifying ideal โฃpatientโข populations for uRDN and optimizing โtreatment protocols to maximize efficacy and long-term benefits.
Frequently Asked Questions about the Paradise Ultrasound System
| Question | Answer | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| What is resistant โขhypertension? | Resistant hypertension is high blood pressureโค that remains uncontrolledโฃ despiteโฃ takingโฃ three or more different types of blood pressure medication, including a diuretic. | |||||||||||
| How does the Paradise system work? | The Paradise system โขusesโ ultrasoundโฃ energy to disrupt theโฃ nerves around the renal arteries, reducingโ sympathetic nervous system activity and lowering bloodโข pressure. | |||||||||||
What โคwere the keyโ findings
CATL’sโฃ Naxtra Sodium-Ion Battery Set to Disrupt EV IndustryTable of Contents Augustโฃ 17, 2025 -โข Contemporary Amperex Technology Co. Limited โ(CATL), the world’s leading battery manufacturer [[1]], is poisedโ to introduce a groundbreakingโฃ sodium-ion battery, dubbed Naxtra,โค that could significantly lower the cost of electric vehicles and extend battery lifespan. Production is rampingโฃ up,withโ initial deliveries toโฃ six automakers โslated for โ2026. A Leap in Batteryโ TechnologyThe Naxtra batteryโฃ represents a strategic shift away from reliance โon lithium, nickel,โฃ manganese, and โฃcobalt – materials often subject to priceโ volatility andโข geopolitical concerns.Rather,it utilizes sodium,an abundant and inexpensive element commonly found in โฃsalt. This innovative approachโข is โprojected to reduce โbattery production costsโ to approximately 10% โขof current lithium-ion โbatteryโ prices. CATL initially unveiled plans for the sodium-ion battery in April 2025 alongside other โadvancements, โฃbut is now moving swiftly toward large-scale production. this commitment โunderscores the company’s โขconfidence in the technology’s potential to reshape the energy storage โlandscape. How โฃNaxtra Differs from Existing BatteriesWhile sodium-ion batteries have been exploredโข for years, previous iterations suffered from lower โenergy โขdensity andโฃ increased weight, limiting their suitability for automotive applications. CATL’s Naxtra battery overcomes these limitations with an electrolyte designed to prevent dendrite formation โฃand degradation, ensuring โstable performance across a wide temperature range. the โbattery operatesโ effectively between -40ยฐC andโข +70ยฐC, โmaintaining 90% of its โฃdischarge power even at -40ยฐC. This resilience is a notableโฃ advantage over customary lithium-ionโ batteries, which can experienceโ performance drops inโค extremeโค temperatures. Key Specifications of the Naxtra Battery
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We’re excited to witness theโ impactโ of CATL’sโ Naxtra battery onโข the futureโ of electric vehicles. Share your โthoughts โinโ the โcomments โbelow, and don’t forget to subscribeโ for โฃthe latest updates on energy storage technology! 
President of the Vietnamese Parliament “Vuong Dinh Hue” (Vuong Dinh Hue) He has announced his resignation on Friday, April 26. After his aide was arrested in connection with the bribery case, Hew became the second high-ranking official to resign in the past five weeks. . After the former president of Vietnam Reuters reports that the position of the Speaker of the National Assembly of Vietnam is under consideration One of the 4 pillars of Vietnam’s administrative power structure. Arranged in order of importance, they include: General Secretary of the Communist Party, President, Prime Minister and Speaker of the National Assembly A statement on the Vietnamese government website said: Hew resigned as Speaker of the National Assembly and resigned from the Politburo. They reasoned that they had contravened the rules of conduct for members of the Communist Party. and they would like to show responsibility as a leader Breaking the rules caused negative criticism from the public. and affecting the reputation of the Communist Party Hew’s resignation comes just days after his assistant was arrested earlier this week. about bribery charges in infrastructure companies He is also the second chief executive to resign within just five weeks, after the former president. By Van Thuong He resigned at the end of March 2024, even though he had only been in office for a year. It is believed that Tueng was pressured to resign because he was involved in a case corruption in Quang Ngai Province, a former province. in the responsibility of President who comes first. Previously, vice president Nguyen Xuan Phuc His resignation in January 2023 was pressured by a corruption case related to the management during the COVID of those under his leadership. General Secretary of the Communist Party Nguyen Phu Trong He has done a massive cleanup of corruption in the country. and as a result more than 459 people were arrested, including members of the Communist Party. to famous businessmen and millionaires in Vietnam Before the beginning of this month Truong Mi Lan A famous businessman known as a real estate mogul and the real owner of Saigon Bank. Commercial Bank (SCB) was sentenced to “death” for the biggest fraud in Vietnam. But recently it was reported that he has filed an appeal against the decision. #Vietnam #parliament #speaker #resigns #response #corruption #crackdown #shakes #politics 
As for the latest court movements, Mr. Sorawit Limprangsi, spokesman for the Court of Justice Came out to provide information that The President of the Supreme Court knew the information as it appeared in the news and was not complacent. We have followed up on the progress and had those involved investigate the reasons and facts in the case. Mr. Sorawit explained that the investigating officer Pattaya City Police Station, Chonburi Province, brought Mr. Jane Krish to submit a request for detention with the Pattaya Provincial Court for the first time on Sept. 26, 2022. which the detention at that time It is a request. Detained at the investigative level and the investigating officer who complained did not object in the case where the accused requested temporary release and after the temporary release The accused also came to contact us to request various actions. with the court unfold! Foreigners set up groups to purchase child sexual services. Know how to get rid of the case and flee back to the country. Clarifying the story of the suspect who bought the child’s sex and ran away! Point out that there are no conditions prohibiting flights outside the country. Later on 7 November 2022, Mr. Jane, the accused, filed a complaint with the Pattaya Provincial Court. Requesting permission to temporarily leave the Kingdom to Germany, reasoning that it was necessary to contact a bank in Germany to identify himself and request that the bank enable the use of the online money withdrawal system that had been suspended and the clothing business that the accused co-operated in doing business With a partner in Germany there was a problem that caused the accused to travel to solve the problem on his own. The accused stated that he had not committed the crime as accused and wished to fight the case to the end. The accused will return to Thailand on 13 Nov. 2022 and will report to the court immediately on 14 Nov. 2022. The accused is willing to post bail to the court by offering to deposit 500,000 baht in cash. Comply with the order. or regulations strictly prescribed by the court The court considers the application and attached documents before granting temporary permission to leave the Kingdom. Because he saw that he had a main residence in Thailand. Having business in Thailand Has a Thai wife and wishes to fight the case By reporting on November 14, 2022, otherwise it will be considered a breach of the insurance contract. On November 14, 2022, the accused’s lawyer applied for an extension of the reporting period to November 29, 2022, which the court granted. But when the appointed day arrived, it appeared that the accused had not come to report himself. The court therefore ordered on December 1, 2022 to issue an arrest warrant for the accused. Along with ordering a fine on the bail bondsman according to the bail contract and seizing the bail money leaving the country, totaling 700,000 baht, the court sent a letter to The Police Commander will also be informed on December 2, 2022. Later on December 16, 2022, the Pattaya Provincial Prosecutor Therefore, the case report was brought to be filed against Mr. Jane. To the Pattaya Provincial Court Until the arraignment date, the defendant has not been arrested and the bail bondsman has not brought the defendant to court. The Pattaya Provincial Court therefore issued a new arrest warrant. (The hearing is after being sued) and in the case it is still uncertain when the defendant will be arrested. Therefore, the case was temporarily removed from the registry. It means that until now The process is now between the police officers who will search for the defendant according to the new arrest warrant. sent to the court for further consideration of the case OBEC announces holiday 4 – 8 Dec. to allow students to prepare for TGAT – TPAT exams. Female net idol complains about stomach burn clinic Set yourself on fire! Mae Fah Luang University issues a statement Clarifying the issue of filing a lawsuit against “Dr. Keng” 2023-12-04 12:44:00 
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