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Gout Treatment Advances: New Therapies and Cardiovascular Benefits Highlighted at EULAR 2025
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Barcelona, Spain – June 16, 2025 – New data presented at the European Alliance of Associations for Rheumatology (EULAR) annual congress in Barcelona showcases significant advancements in gout treatment, emphasizing the importance of achieving target serum urate levels and introducing novel therapeutic options. The research underscores the link between effective gout management and reduced cardiovascular risk, alongside the development of promising new urate-lowering drugs [[source: EULAR]].
Targeting Serum Urate Levels for Cardiovascular Protection
Gout flares have been linked to an increased risk of cardiovascular events. A study by Edoardo Cipolletta and colleagues,analyzing data from over 116,000 patients in England and Sweden,revealed that achieving a serum urate level of โค360 ฮผmol/L within the frist year of urate-lowering therapy significantly improved 5-year MACE-free survival and lowered the risk of major adverse cardiovascular events (MACE). This highlights the importance of proactive gout management in mitigating cardiovascular risks [[source: EULAR]].
Did You Know? Maintaining a serum urate level below 360 ฮผmol/L can significantly reduce the risk of cardiovascular events in gout patients.
The study’s findings remained consistent across various analyses, including different MACE definitions and censoring follow-up upon therapy discontinuation. Notably, the beneficial effect was more pronounced in patients over 65 years old. These results reinforce the need for targeted urate-lowering strategies in gout management to improve overall patient outcomes.
Emerging Therapies for Urate Lowering
Several new therapies are under development to effectively lower urate levels in gout patients. Pozdeutinurad (AR882), a selective URAT1 inhibitor, has demonstrated sustained reductions in serum urate and significant reductions in tophi. A Phase 2 open-label trial presented by Robert Keenan evaluated the long-term safety and tolerability of pozdeutinurad, alone or combined with allopurinol, in patients with subcutaneous tophi [[source: EULAR]].
The trial results indicated that pozdeutinurad was generally safe and well-tolerated over 18 months, with most treatment-emergent adverse events (TEAE) being mild to moderate. Gout flares were the most frequent adverse event in the first six months, with a decreasing trend thereafter.There were no clinically significant liver function abnormalities or serum creatinine elevations reported.
Pro tip: Newer gout medications focus on selectively inhibiting URAT1, a key protein involved in uric acid reabsorption in the kidneys.
Another promising therapy, ruzinurad, also a URAT1 inhibitor, was evaluated in a Phase 3 study presented by Huihua ding.The study compared ruzinurad to allopurinol over a 16-week double-blind period. Results showed that a significantly greater proportion of patients in the ruzinurad group achieved the target serum urate level of โค360 ฮผmol/L at the last two monthly measurements compared to the allopurinol group (39.7% vs. 26.5%). This difference was maintained until Week 52 [[source: EULAR]].
During the 52-week treatment period, TEAE occurred in 89.7% and 91.7% of patients in the ruzinurad and allopurinol groups,respectively. The most common adverse events included gout flares, increased alanine aminotransferase, upper respiratory tract infection, and increased blood creatinine. The study concluded that ruzinurad demonstrated superior urate-lowering efficacy compared to allopurinol and exhibited a well-tolerated safety profile in patients with hyperuricemia associated with primary gout.
gout Treatment Comparison
| Therapy | Mechanism of Action | Efficacy (Target Urate โค360 ฮผmol/L) | Common Adverse Events |
|---|---|---|---|
| Allopurinol | Urate-lowering therapy [[2]] | 26.5% (at week 16) | Gout flares, increased alanine aminotransferase |
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Jakarta – Gout or gout is joint inflammation caused by high levels of uric acid in the body. This compound is produced by the body naturally to break down purines. After completing its function, the uric acid will be excreted through urine. This condition can appear within 12 to 24 hours and will subside over time or when uric acid levels decrease. Gout can recur if the sufferer does not pay attention to their diet, does not take regular medication and maintains a healthy lifestyle. So, can gout be completely cured?Gout attacks are usually characterized by stabbing pain in the joints that causes redness and swelling. Quoted from the page Johns Hopkins Arthritis Centerpain due to gout can develop quickly in just a few hours. This condition can subside on its own, but requires care and treatment. This is necessary so that uric acid levels can decrease and prevent the risk of complications. With proper treatment, this condition can heal within five to seven days. Even though the pain that appears begins to subside or heals, it does not mean that gout has completely healed. According to the US Centers for Disease Control and Prevention (CDC), until now there is no medicine that can treat gout until it is completely cured. Current medical and natural treatments and treatments only help reduce the complaints felt by patients. Apart from that, it only prevents severe gout attacks and prevents recurrence. Quoted from the page Arthritis Health, if someone has had a gout attack, it is likely that it will appear again and cannot be predicted until it lasts a long time. Pain can appear in the big toe, joints in the instep, heel, ankle, and knee. If gout is chronic, it can cause permanent joint damage and result in disability. That is what makes gout sufferers need to take appropriate treatment to control their uric acid levels. If gout recurs, how do you deal with it?Gout cannot be cured completely. However, it can still be controlled with treatment and changing lifestyle, such as:
However, it is recommended to consult a doctor first. This is to find out the right way to treat or control gout which often recurs. Watch Video “Cameroon Starts World’s First Malaria Vaccination Program” (sao/naf) 2024-01-23 07:31:23 
High levels of uric acid in the blood (Hyperuricemia) an abnormality that is often found. The medical profession will determine when The uric acid in the blood is above the limit. The solubility of uric acid (Monosodium urate) is 6.8 mg/dL at a temperature of 37 degrees Celsius, considered to have high uric acid.
โHigh uric acidโ what should I eat? Recommend low purine foods that can be eaten every day to reduce gout. How to treat acute and chronic inflammation of “gout” Recommendations for use of medicine by a doctor However, whether it is weight, age, gender, blood pressure and alcohol consumption. These are all factors that can cause high uric acid in the blood. High uric acid risks gout?If the level of uric acid is high for a long time It can affect the occurrence of gout. It was found that people with blood uric acid levels of more than 9 mg/dL for 5 years had a 22% chance of having gout, while those with uric acid levels of 7 โ 8.9 mg/dL. . For 5 years, only 3% were found. For patients diagnosed with high uric acid But there are still no symptoms of gout. The doctor will recommend guidelines for self-care. But for those who are at very high risk or already have gout. The doctor will consider treating with medication. Because if not treated and the accumulation of uric acid is much higher It may occur as a tophi or bump under the skin in joints such as the fingers, feet, elbows, or Achilles tendons. Although this lump does not cause pain, But if the symptoms of the disease recur when? It can cause infection and severe joint pain. Until causing the joint to become distorted and deformed and not disappear There is also a chance of kidney stones arising from the buildup of urate crystals in the urinary tract. This can cause abnormal kidney function or kidney failure. โFake goutโ: How are the symptoms different from gout? Who needs to be careful? I don’t want to have gout. What should I do?
However, high levels of uric acid in the blood Often detected in health examinations. Therefore, this point should not be neglected. Because gout and other chronic diseases are like other diseases. Early detection of risks will help ensure good protection. Or if the disease is found early, it can reduce its spread. Thank you for information from: Samitivej Hospital and Paolo Hospital High levels of uric acid accumulate in the blood, triggering gout. Where can it be found? Check the differences Gout and osteoarthritis โArthritisโ that is often found 2024-01-21 03:39:00 #high #uric #acid #blood #long #Risk #gout #kidney #stones #PPTVHD36
Jakarta – Gout is a condition that is not unfamiliar to society. The characteristic features of this disorder are pain and swelling in the joints. The painful part seems to change shape due to swelling. Quoted from the Digital Repository of the Muhammadiyah University of East Kalimantan (UMKT), uric acid is actually part of the body’s metabolism. Uric acid is the final product of purines, one of the components of nucleic acids. Quoted from the Pocket Book for Gout Control Cadres in the Community from FKKMK UGM, gout is a common form of arthritis that is very painful. Repeated attacks of gout can result in gouty arthritis. As part of the processing results, uric acid is naturally found in the body. Normal uric acid levels according to WHO in men are 3.5-7 mg/dl, while in women it is 2.6-6 mg/dl. More than this amount, there is a risk of uric acid accumulating in the joints to form crystals. The very sharp tip of the crystal will cause an inflammatory response that can lead to gout attacks. Characteristics of Uric Acid DiseaseQuoted from the Denpasar Health Polytechnic Repository and the Surabaya Muhammadiyah University Repository, the following are the characteristics of gout: Swelling in certain jointsPain and decreased function in the joint affected by gout, often found in the big toe. Feeling hot in the swollen area. The joint looks red. Fever accompanied by chills. The heartbeat becomes fast. There has been more than one attack in the joint which is usually acute. The period between attacks can be uneventful. symptoms (asymptomatic intercritical) There is a buildup of uric acid crystals in the fluid and tissue of the joints, kidneys, cartilage and other locations. If the buildup becomes kidney stones, the patient will experience severe back pain. The symptoms of gout will gradually disappear. After that, it does not cause any more symptoms until the next attack occurs. These symptoms can occur in the kneecaps, backs of the arms, back tendons, ankles and earlobes. Causes of Gout DiseaseHere are some causes of gout: 1. Genetic factorsOne of the risk factors for gout is genetic or hereditary factors. Gout is categorized as a multifactorial disease because this disease involves heredity and environmental factors. 2. DietFood has a significant influence on the emergence of disease. The food we consume is interconnected with uric acid. This is related to the purine content found in the food we consume. Unhealthy eating patterns can affect the risk of gout. 3. Alcohol consumptionConsuming large amounts of alcoholic beverages over a long period of time can cause a decrease or even damage to kidney function. Impaired kidney function can cause the kidneys to be unable to excrete uric acid so that uric acid levels increase. 4. ObesityBeing overweight can be a serious problem when it causes various diseases. Starting from, diabetes mellitus, high blood pressure, stroke, and gout. Some gout sufferers are obese. 5. AgeElderly people are more susceptible to disease. The decreasing physical strength and endurance of the body disrupts the working mechanisms of organs and makes them susceptible to disease. 6. GenderGenerally, people who often suffer from gout are men. This is because men naturally have higher levels of uric acid in the blood than women. Men also do not have high levels of the hormone estrogen, so it is difficult for uric acid to be excreted through urine. This can cause the risk of increasing uric acid levels in the body. How to Treat GoutAccording to Medical News Today, here are some easy ways to treat gout: Drink a lot of waterOne way to reduce these symptoms is to consume more water. Increasing fluid consumption can encourage the kidneys to excrete fluid and reduce swelling in gout sufferers Apply ice to the jointCompressing ice wrapped in cloth on the joints can help reduce inflammation caused by gout. You can compress the painful area with ice cubes for 20 minutes to relieve pain. Reduce stressStress can worsen gout symptoms. You can get enough rest, exercise, or meditate to reduce stress. Elevates the joints affected by goutGout can cause pain and swelling, especially in the feet, hands, knees and ankles. One way to reduce swelling is to elevate the painful joint. This is to encourage blood and fluid to move away from the joint. Taking over-the-counter pain medicationOver-the-counter anti-inflammatory drugs may be able to treat the pain and swelling caused by gout. However, you should not consume more than the recommended dose. This is an explanation of the characteristics of gout and how to deal with it. Hope it is useful. Watch the video “Tips to avoid getting lower back pain when WFH” (row/row) 2023-10-28 23:30:00 
Tuesday, 3 October 2023 – 05:05 WIB VIVA Lifestyle โ Although gout is more common in adults, including the elderly, young people can also experience this condition. Gout is a disease associated with increased levels of uric acid in the blood, which can cause pain and inflammation in the joints. The following are the characteristics of gout that need to be watched out for, even in young people. Joint Pain: Young people with gout may experience sharp pain, especially in certain joints such as the fingers, wrists, elbows, knees, or toes. This pain can occur suddenly and its intensity can vary. Swelling and Inflammation: Affected joints may experience swelling, redness, and inflammation around them. This can make movement difficult and painful. Swelling of the Lymph Nodes: Some young people with gout may experience swelling of the lymph nodes around the affected joints. Fatigue and Malaise: Young people with gout may feel tired and weak in general, even without excessive activity. Illustration of feet/tingling/varicose veins/goutKidney Stones: High uric acid in the blood can lead to the formation of kidney stones, which can cause severe pain in the waist area, accompanied by nausea, vomiting, and blood in the urine. Skin That Feels Hot and Red: The skin around the joints affected by gout can feel warm, red, and shiny. Limited Mobility: Young people with gout may experience limited mobility and difficulty moving the affected joints. Diet and Lifestyle: Young people with eating habits high in purine (a substance that is broken down into uric acid in the body) and a less active lifestyle have a higher risk of developing gout. If you suspect that a young person is experiencing the symptoms above, you should consult a doctor for further examination, diagnosis and an appropriate management plan. Good monitoring and management can help control uric acid levels and prevent further complications. 2023-10-02 22:05:02 
Jakarta – Question: Hello Doc, some time ago I checked the uric acid levels in my blood. It turns out the results show 12.5 points. Finally I was directed to an internist and given medicine. Can gout be cured with medication and do you have to take this medication for the rest of your life, Doc? Coco (female, 21 years old) Answer: The limit for hyperuricemia is 6.8. Meanwhile, uric acid lowering therapy is above 9 if the patient is asymptomatic. Apart from that, medication will also be given if the points are above 8. Especially for sufferers without symptoms, but with a risk of heart and blood vessel disease. However, if the patient has symptoms of gout or pain and swelling in the joints, generally in the big toe joint, then the target is to reduce uric acid to below 6. Increased uric acid is influenced by several factors, such as: Foodstuffs containing excessive purine Green vegetablesEmptingImpaired excretion through the kidneys, such as decreased kidney functionLack of activity Dr Vanyield Fridt Merdika Simanjuntak General practitioners Primaya Hospital West Bekasi About Health Consultation Reader detikcom Those who have questions about health can send questions along with their name, age and gender via the Consultation form detikHealthCLICK HERE. The identity of the questioner can be written clearly or disguised, according to the wishes of the questioner. Identity confidentiality is guaranteed. Want to know your mental health condition? Try taking a psychological test HERE. Watch the video “Tips for minimizing potential health problems due to hot weather” (star/kna) 2023-10-02 02:09:05 Newer Posts |