forehead

Let the music continue to play in an innovative project on the frontier of knowledge such as Sensoxenomaand that it has the financial support it needs to be able to continue delving into a new path in which It has been found that melodies fine-tune the expression of altered genes in patients with neurodegenerative pathologiesare the two main demands of the orchestra made up of scientists from the Santiago Health Research Institute (IDIS), members of the Royal Philharmonic and associations of those affected.

This is what was put on the table during the presentation of the first results of this research project. powered by the Population Genetics in Medicine Group (GenPoB) and the Genetics, Vaccines and Infectious Diseases Research Group (GenVIP) of the USC and the IDSled by Professor Antonio Salas and the head of Pediatrics at CHUS, Federico Martinón, in a meeting in which the Sensoxenoma coordinator, Laura Navarro, participated; the technical director of the Real Filharmonía, Sabela García, and the manager of the CHUS health area, Eloína Núñez.

Federico Martinón: “We will be able to go faster and better if we are able to attract resources to be able to accelerate in this line”

Starting from “our first working hypothesis that behind all this brain plasticity, the ability of music to generate changes in the brain“There must have been molecules,” according to Antonio Salas, what has been proven is that “we have been able to recover 35,000 molecules that represent what those genes express; Let’s say that genes are a score that must be interpreted, and We have managed to overcome the challenge of rescuing 35,000 molecules from those genomic scores “that represent those alterations that music causes.”

They got it after analyze samples from users of the Agadea Alzheimer’s association and from healthy people attending the Real Filharmonía concerts in which last year blood and saliva samples were extracted before and after the performance, in an initiative in which Sanarte also collaborated.

Salas highlighted that the first results indicate that “there are thousands of genes that are altered and, in addition, music impacts differently on the genes of patients and those of people without cognitive impairment,” since “those affected are more “sensitive to music, it impacts twice as many genes.”

Antonio Salas: “Thousands of genes are altered with music, and they do so differentially in healthy people and in patients”

After recognizing that it is difficult to refine the role that each of these genes plays in the pathology in relation to musicindicated that “it is much easier to understand those routes that are being modified, to see that patients tend to express a little more than healthy people, since they dose that gene expression a little better.”

He stressed that “one of the most striking things is that if the disease has altered genes, with music we are seeing that these genes are expressed in the opposite direction; That is, there is a compensatory effect of the disease.”

Federico Martinón, who explained that “what we present here It’s a proof of concept.since we had to demonstrate whether these next-generation technologies in the context of infectious disease research could be used to evaluate the impact of musical stimulation on genetic expression, and we have achieved it,” he was satisfied with achieving the second challenge of to see “if we could give a differential response in patients with neurodegenerative processes compared to healthy women, and not only have we accomplished it, but it has surprised us.”

He pointed out that “They have thousands of samples pending analysis”, but said that they lack resources because “we have gone very fast, but we can go even further and better if we are able to attract resources.”

Upcoming concerts

The new Royal Philharmonic performances in which data will be collected will be on the 29th and 30th of this month at 6:30 p.m. In the first, samples will be taken deaf, blind and people with autism spectrum disorder, thanks to the collaboration of the Federation of Deaf People of Galicia, ONCE, Aspanaes and Asperga. The second will be a concert open to the general public. Tickets cost three euros.

2023-09-20 16:05:04
#music #play #neurodegenerative #pathologies