FDA & State AGs Warn of Risks with Compounded,Counterfeit GLP-1 Weight loss Drugs
A growing chorus of warnings is sounding regarding the potential dangers of compounded and counterfeit versions of GLP-1 medications-drugs increasingly popular for weight loss-as authorities investigate a surge in unregulated products. The FDA and attorneys general from multiple states are urging caution and increased oversight amid concerns about unknown ingredients, dosages, and origins.
GLP-1 receptor agonists like Zepbound and Wegovy are prescribed to treat obesity and related conditions, but demand has fueled a market for compounded versions-drugs mixed by pharmacies-and outright counterfeits.Dr. Hsieh warns, “They just don’t know where it’s coming from. They have absolutely no idea what’s in it, how much is in it, and where it’s coming from.It’s that simple.” The FDA has issued a formal warning about these unapproved drugs, available here.
These concerns extend beyond the lack of FDA approval. Experts emphasize the importance of combining GLP-1 use with lifestyle changes, including proper nutrition and exercise, to avoid muscle loss, weight regain, and other side effects.”we say that GLP-1s are training wheels. They’re a tool. They’re not the cure. The cure is you learn how to eat differently, how to have different habits, how to have different ways of thinking about food,” explains dr. Hsieh.
Pat, a former Zepbound user, successfully transitioned to a healthier lifestyle and is no longer on the medication. He credits his commitment to change, stating, “I was ready, and I was behind it. I knew I was going to make this work. It was time to make this work.I wanted to see my grandkids graduate from high school,so I was really going to follow the rules.” He affirmed, “I’m not going back to where I was because it’s too hard to get where I’m at.”
The issue has prompted action from state officials. attorneys general from dozens of states, including indiana and Michigan, have jointly called on the FDA to strengthen its crackdown on compounding and counterfeiting. The letter to the FDA can be found here, and Michigan Attorney General Nessel’s declaration is available here.
A spokesperson for the Indiana Attorney General’s office stated, “GLP1s are being used widely by consumers both inside and outside of Indiana. As a product prescribed by licensed physicians and made in Indiana and elsewhere, GLP1s are certainly something that the Office is aware of and paying attention to. Keeping hoosiers safe and ensuring that they and local businesses are not being taken advantage of is a meaningful priority.”
Consumers in Indiana who suspect issues with GLP-1 medications can file a complaint here.