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Ancestry’s Role in Colorectal Cancer Risk: Brazilian Study Reveals Genetic Insights

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

Summary of the Research on Colorectal Cancer Risk in brazil

This research study, conducted with a large adn diverse Brazilian cohort (nearly 2,000 participants), has identified key genetic markers and the role of ancestry in colorectal cancer risk. Here’s a breakdown of the key findings:

1. Four Independent Genetic Markers:

The study identified four genetic markers that independently contribute to either increased risk or protection against colorectal cancer.
 Importantly, these are not mutations occurring within the tumor itself, but rather normal genetic variations inherited from parents – like those influencing skin color. We are born with these variations.

2. Role of Ancestry:

Individuals with lower proportions of African and Asian ancestry were found to be at higher risk of developing colorectal cancer.
 This supports the idea that genetic components inherited from African and Asian populations can have a protective effect. The researchers acknowledge this association could be linked to lifestyle factors common within these ancestral groups (e.g., diet rich in vegetables and fish).3. Importance of Sample Size & Diversity:

This study is significant due to its large sample size and representativeness of the Brazilian population, addressing limitations of previous smaller studies.
It highlights the importance of studying genetic diversity within specific populations, as findings from US or European studies may not directly apply to Brazil.

4. Future Implications: Personalized Medicine:

while these genetic variations cannot be changed,understanding them can lead to personalized prevention and tracking strategies. Individuals with risk-associated variants,combined with unhealthy lifestyles,face a considerably higher overall risk.
 The researchers aim to combine genetic data with environmental factors to create more effective, tailored screening programs – prioritizing those with higher genetic risk.

5. Ongoing Research:

The team is now working on mapping up to 3 million genetic variations specifically within the Brazilian population.
 The goal is to develop a unique risk score for Brazilians, taking into account thier specific genetic characteristics, to improve disease prevention and treatment.

In essence, this research emphasizes the importance of considering genetic ancestry and individual genetic profiles when addressing colorectal cancer risk in Brazil, paving the way for more effective and personalized healthcare strategies.

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Health

Oral Cancer Rising in India: Symptoms, Prevention & Early Detection

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

Oral Cancer Rising ⁤in Young Adults: Don’t Ignore Mouth Sores, Warns Oncologist

(world-Today-News.com) – New⁢ Delhi, India ‌- ⁢A ⁤concerning trend is emerging in India: a rise in oral cancer diagnoses, especially among young adults. Oncologists are urging the public to be⁣ vigilant about⁤ persistent mouth sores⁢ and unusual patches, as early detection is now linked to a dramatically improved survival rate – exceeding 90%.

Oral cancer, a type of Head and Neck Squamous Cell Carcinoma (HNSCC), ⁤accounts for 26% of cancers in Indian ‍men and 8% in women. Incidence ‌rates are particularly high in the Northeast, reaching 31.8 cases per 100,000 males. Nationwide, estimates suggest around 20 cases ⁢per 100,000 population.

“Early detection ​is absolutely critical,” explains Dr. Minish Jain, Director ‍of Medical Oncology at Ruby Hall Clinic. “When caught‍ early, the 5-year survival rate for oral cancer is ‌above 80%.However, this plummets ⁢to a mere 20-30% ⁣in advanced stages, even with aggressive⁣ treatment.”

(Image: Early⁤ detection of oral cancer can boost survival rates to 90% amid rising incidence. (Jerussa Paredes))

A Shifting ​Landscape: Cancer in Non-Tobacco Users

Traditionally,oral cancer has

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Health

Cardiologist reveals why people in 30s, 40s are collapsing during workouts: Treadmill isn’t the enemy but… | Health

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

Young Adults Collapsing During Exercise: It’s Not Your Workout

Hidden metabolic issues, not treadmills, blamed for alarming health events.

An alarming trend of individuals in their 30s and 40s collapsing during physical activity is raising concerns, but experts say the gym equipment isn’t the culprit.

The True Culprit Unveiled

According to functional medicine expert and cardiologist, Dr. Alok Chopra, the issue isn’t high-intensity workouts themselves. Instead, it’s often an underlying, undetected metabolic dysfunction that poses the real danger.

Dr. Chopra explained in a recent Instagram post that many people are experiencing heart-related problems due to factors they’ve overlooked for years. “Fast track to a heart attack. It’s not the treadmills triggering heart issues for the under 40s, it’s the metabolic dysfunction,” he stated.

Silent Risk Factors Identified

Dr. Chopra highlighted several key contributors to these concerning incidents:

  • Poor metabolic health
  • Silent insulin resistance
  • Chronic inflammation
  • Excessive stress
  • Inadequate sleep and recovery
  • Diets lacking essential nutrients

He emphasized that while cardiac events may occur during intense exercise, the workout is merely the trigger, not the root cause. “If your body is already a ticking time bomb, a sudden workout might just light the fuse. The treadmill isn’t the enemy. The enemy is what you’re ignoring,” he advised.

The key isn’t avoiding exercise—it’s detecting and addressing the silent risk factors before they turn fatal. (Freepik)

Prioritizing Early Detection

The path forward involves proactive health monitoring. Cardiologist Dr. Naveen Bhamri suggests that beyond a standard ECG, tests like the Treadmill Test (TMT) and echocardiography are crucial for a comprehensive understanding of heart health.

This aligns with a growing body of research indicating a rise in cardiac events among younger demographics. A recent study published in the *Journal of the American Medical Association* noted a significant increase in sudden cardiac arrest among adults under 35, with lifestyle factors like poor diet and chronic stress being key contributors (JAMA, 2023).

The fundamental message for individuals is clear: focus on identifying and managing underlying health issues rather than fearing exercise itself. Early detection and lifestyle adjustments are paramount to preventing serious cardiac events.

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Health

Parkinson’s Disease Symptoms: Causes, Diagnosis & Initial Signs

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

Parkinson’s Disease: understanding the Progressive Neurological Disorder and Its Symptoms

Jakarta – Parkinson’s disease, a progressive neurological disorder, gradually impacts the nervous system and a person’s ability to control body movements.This condition affects not only the general public but also prominent figures. Ozzy Osbourne, the legendary Heavy Metal musician, publicly shared his Parkinson’s diagnosis in 2020, though he was initially diagnosed in 2003.

What Are the Symptoms of Parkinson’s Disease?

The initial symptoms of Parkinson’s disease are often subtle and may go unnoticed for months or even years. According to the Mayo Clinic, the first signs commonly manifest as tremors that are barely perceptible, frequently beginning in one hand. These tremors can also affect the legs or jaw.

Typically, the tremor starts in the hand or finger. Though, it can also originate in the legs or jaw. Individuals may experience trembling in their hands while at rest or when experiencing stress.

In addition to tremors, other significant symptoms of Parkinson’s disease include:

  • Brady
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Health

Oncologist shares what most men miss about prostate cancer symptoms and how early screening can be life-saving | Health

by Dr. Michael Lee – Health Editor
written by Dr. Michael Lee – Health Editor

Oncologist Reveals Hidden Prostate Cancer Signs, Screening’s Lifesaving Role

Prostate cancer, a common threat for men, often hides its presence. Understanding its subtle early signals and the importance of timely detection can significantly improve outcomes. Dr. Ravi Chandran K, a leading uro-oncologist, highlights crucial symptoms and treatment avenues for this prevalent disease.

Unveiling the Subtle Signals

Early prostate cancer often presents no symptoms, necessitating regular check-ups for those at higher risk. Common indicators, according to Dr. Ravi, include urinary difficulties such as frequent urination, reduced flow, urgency, and painful urination.

Other symptoms may involve blood in urine or semen and new erectile function issues. Recurring pain in the lower pelvis, hips, or lower back could indicate the cancer has spread. However, these symptoms can also stem from benign conditions, requiring careful medical evaluation.

Diagnostic Procedures

Early diagnosis dramatically enhances treatment success. The two main screening tests include the Prostate-Specific Antigen (PSA) test and the Digital Rectal Examination (DRE). Elevated PSA levels may indicate prostate cancer, though other conditions can cause this. Abnormal results warrant further tests.

Treatment Options

Treatment decisions depend on cancer stage, biopsy results, PSA levels, age, health, and personal preferences. Active surveillance, surgery, radiation therapy, hormone therapy, chemotherapy, targeted therapies, and radioligand therapy are potential treatment options.

The National Cancer Institute reports that the five-year survival rate for prostate cancer is nearly 100% when detected early and confined to the prostate, underscoring the importance of regular screening and early detection.

Treatment Details

Men with slower-growing, low-risk cancer may choose active surveillance. This involves monitoring PSA levels, repeated MRIs, and possible biopsies. The approach aims to manage the cancer closely, intervening when early signs of progression emerge.

Radical Prostatectomy is another treatment option, involving the removal of the prostate and seminal vesicles. Robot-assisted surgery is the standard, providing good outcomes while minimizing side effects.

Hormone therapy reduces testosterone to combat high-risk prostate cancer, often alongside radiation.(Pexels)

Radiation therapy, through external beams or internal seeds (brachytherapy), can treat localized or locally advanced disease. Side effects include urinary, bowel, and sexual issues, often manageable. Hormone therapy aims to reduce testosterone, the fuel for prostate cancer, frequently used alongside radiation in high-risk cases.

Chemotherapy targets high-risk or advanced cases, slowing progression and improving survival. Other options include targeted and immunotherapy, with radioligand therapy emerging for metastatic disease, using radioactive molecules targeting prostate-specific markers.

Living with Prostate Cancer

A prostate cancer diagnosis can be overwhelming, but early detection often leads to curative treatments. Multidisciplinary care, including urologists, oncologists, psychologists, and dietitians, supports patients through the challenges of treatment and beyond.

Dr. Ravi concludes, “Prostate cancer is considerably more common in men than you may realise, and if caught early enough, awareness, timely detection, and access to the right interventions can often lead to curative treatment.” He emphasizes consulting a urologist/uro-oncologist for screening, especially for those over 50 or with risk factors.

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Health

New milestone in medicine

by Chief editor of world-today-news.com
written by Chief editor of world-today-news.com

Early detection is often crucial for the successful treatment of a disease. A new test could revolutionize it, and it only requires a drop of blood.

Our blood reveals a lot about our state of health, showing signs of organ damage, inflammation or metabolic dysfunction. But blood can also provide information about impending illnesses. This has already been proven for various types of cancer.

Now researchers have focused on the proteins in the blood and have come to astonishing results. They examined 2,900 proteins in over 40,000 blood samples from the UK Biobank – a large long-term observation of the health of now over 500,000 people.

Blood samples were taken from the selected subjects and linked to data on their health before, during and up to ten years after the blood sample was taken. The British scientists then investigated which specific proteins were associated with a particular disease. And finally, what the presence of these proteins in previous samples says about whether the disease can be predicted based on them.

The result is astonishing: “For 163 diseases, just five proteins were enough to perform as well as the clinical models – without any additional health information being required,” reports study leader Julia Carrasco-Zanini. “For 67 common and rare diseases, the evaluation of five to 20 blood proteins significantly improved the clinical models.”

To understand: Prediction models currently often refer to certain pre-existing conditions, lifestyle factors or specific blood values ​​(sugar or cholesterol levels). The determination of individual proteins is also included. But now there are apparently thousands more new markers.

The diseases that can be predicted using the protein test include various types of cancer such as prostate cancer, multiple myeloma or non-Hodgkin lymphoma (blood cancers), the lung disease COPD, liver and kidney diseases, rheumatism or some heart diseases.

However, as the science magazine scinexx.de reports, there are also some medical conditions for which protein tests offer little advantage over existing methods. These include bacterial infections, benign colon polyps, osteoporosis and cataracts. “These diseases require samples from other tissues or completely different approaches in order to be better predicted,” say the researchers.

They unanimously see the research result as a major step in the new form of diagnostics. The test will now be tested on an even larger scale and within different population groups. Initially, the focus will be on “high priority” diseases, i.e. those that are likely to be serious, progress quickly or occur frequently.

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