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Doctor Thira

The Impact of COVID-19 on the Brain: Long-Term Neurological Complications and Potential Implications

by Chief editor of world-today-news.com August 13, 2023

written by Chief editor of world-today-news.com

On August 13, 2023 Assoc.Prof.Dr.Theera Worathanarat or “Doctor Theera” Faculty of Medicine Chulalongkorn University Facebook post updates the issue. “COVID-19” stating that

The COVID-19 virus and the brain

It is well known today that the infectionCOVID-19 virus or SARS-CoV-2 is not only infectious in the respiratory system but can spread to almost every system in the body It has been proven by research from around the world.

Not many patients after recovering from the initial infection back with persistent abnormalities or reappear after recovering from illness and is continuing in the long run known as Long COVID or Post-COVID conditions

Symptoms that occur in the long run occur in every system in the body by resulting in illness impair performance in daily life worsen the quality of life Both in school, work and personal life. Including various expenses It is a burden on patients, families and society.

common symptoms There are both tired and exhausted things. muscle and joint pain including problems in the vital systems of the body both heart and blood vessels respiratory system digestive system urinary system And very important is the brain and nervous system. Which usually comes with problems with concentration, emotions, thoughts, memory, etc.

Mechanisms that cause abnormalities in Long COVID occur from many mechanisms, such as the presence of the virus or its fragments remaining in the body’s organs, the tissues or cells in that system. Destroyed by viruses, autoimmunity, infections provoke chronic inflammatory processes, including infection with COVID-19. Encourage infectious viruses that are hidden in the body to become active, etc.

One of the studies definitively proved that viral fragments remain in the brain after infection.COVID-19 It comes from a German research team. The study was published in bioRxiv last April. by detecting the cortical fragments of the virus both in the brain bone marrow of the skull and the cortex from the bodies of patients who died from COVID-19 About half of the total which led to the medical hypothesis that

The remains of the virus especially in the marrow part of the skull It is likely to lead to inflammation. interfere with brain function and/or destroy nerve cells in the brain This will cause problems with brain and nervous system abnormalities in Long COVID patients.

The German team conducted further studies and proposed that the above mechanisms could be used to explain brain and nervous system problems from other diseases. that are similar as well It was published in the medical science journal Cell on August 9th.

protection against infection or not repeating is the best

Live a conscious life, don’t be careless, always protect yourself.

wearing a mask correctly It will greatly reduce the risk.

refer

1. SARS-CoV-2 Spike Protein Accumulation in the Skull-Meninges-Brain Axis: Potential Implications for Long-Term Neurological Complications in post-COVID-19. bioRxiv. 5 April 2023.

2. Distinct molecular profiles of skull bone marrow in health and neurological disorders. Cell. 9 August 2023.

2023-08-12 23:47:00

#Thira #updated #COVID19 #brain #causing #problems #concentration #emotions #thoughts #memory

August 13, 2023 0 comments

Health

Mr. Thira Updates COVID-19 Strain EG.5.1, Potential Outbreak at Year-end & Comparison of Symptoms in Various Species

by Chief editor of world-today-news.com August 6, 2023

written by Chief editor of world-today-news.com

“Mr. Thira” updates the COVID-19 strain EG.5.1, a candidate that may lead to an outbreak at the end of this year. ready to compare the symptoms of COVID-19 various species

On August 6, 2023 Assoc.Prof.Dr.Theera Worathanarat or “Doctor Thira“Faculty of Medicine Chulalongkorn University Facebook post updates the issue. “COVID-19” (Covid-19) stating that

Regarding EG.5.1, a favorite horse that may lead to an outbreak at the end of this year

It is a mutated subspecies from XBB.1.9.2, also known as XBB.1.9.2. XBB.1.9.2.5.1

In comparison, it was like a great-grandson of XBB and a great-grandson of XBB.1.9 and something like that.

what makes EG.5.1 It is now a global concern. The detection rate is increasing faster than the different species. Previous outbreaks, including XBB.1.5, XBB.1.16, as well as XBB.1.9.1/1.9.2

Until this moment, the information became clearer and clearer. that is as expected

The latest data from the US CDC estimates that until August 5, 2023, Omicron subspecies EG.5.1 It had the highest detection rate at 17.3%, ahead of other subspecies such as XBB.1.16 (15.6%), XBB.2.3 (11.2%), XBB.1.5 (10.3%).

While the UK HSA released its report on August 2, It suggests that EG.5.1 already accounts for 12% of detections in the UK and is on the rise.

Overall, it is now found around 20% in Asia, 10% in Europe, 7% in North America. (except in the United States, which is as high as 17.3%)

Why did EG.5.1 lead the others?

Last night’s data from Cao YR, Peking University. This suggests that EG.5.1 is genetically modified at F456L, which makes it more potent.immune evasionmuch more than the previous species.

interesting is Even immunogenic testing in the sera of people previously infected with the XBB strain was also found to be immune-resistant.

In addition, Cao YR has also found that various subspecies happened The change in position F456L in conjunction with L455F also requires monitoring. because it has the potential to make both more resistant to immunity and more tightly binds to the ACE2 receptor on the target cell surface. This may make it more likely to become infected and spread the infection. or more severe illness

However, the one that is most notable right now is EG.5.1 because it is clearly more widespread worldwide.

Factors including viruses that have improved performance In addition to the conditions that we tend to tend to like other countries in 6-10 weeks and the schedule of activities and festivals at the end of the year

after October There may be a chance that it will erupt. Should live a daily life consciously, not carelessly, always protect yourself. beware of crowded poor ventilation Do not share food with other people outside the home. wearing a mask correctly It will greatly reduce the risk.

Comparison of symptoms of COVID-19 various species

Team from the UK presenting the results of a comparative study of the symptoms of People infected with COVID-19 various species In the past, how are they similar or different?

Published in the scientific journal Scientific Reports on August 2, it was noted that Omicron That, whether it is BA.1, BA.2, BA.5, they all have quite a different illness from the previous species.

especially olfactory symptoms tongue can’t taste are often found in previous species Both primitive alpha delta species, but less common during Omicron.

The most notable symptoms of Omicron are cough, fatigue/fatigue, headache, muscle aches, sore throat, nasal congestion and runny nose.

refer
Scientific Reports. 2 August 2023

2023-08-06 01:29:00

#Mor #Theera #expects #COVID #EG.5.1 #candidate #lead #outbreak #year

August 6, 2023 0 comments

Health

EG.5.1 Strain of COVID-19 Emerges in Europe, Increasing Outbreaks: Updates by Dr. Theera

by Chief editor of world-today-news.com July 24, 2023

written by Chief editor of world-today-news.com

“Mor Theera” updated COVID-19, the EG.5.1 strain found outbreaks in Portugal about 25%, Austria 17%, and Sweden 13%, increasing in European countries. Just like what we see in Asia and America.

On July 24, 2023 Assoc.Prof.Dr.Theera Worathanarat or “Doctor Theera” Faculty of Medicine Chulalongkorn University Facebook post updates the issue. “COVID-19” (COVID-19), stating that

1. EG.5.1 in Europe

information from GISAID (Credit: Honey M, Australia) points out that EG.5.1 (in the line of EG.5 which the WHO has recently added to the watchlist Variant under Monitoring) has increased in European countries. Just like what we see in Asia and America.

In Portugal it is about 25%, Austria 17% and Sweden 13%.

With this trend of expansion across multiple continents, it is expected that EG.5.x It is likely to have the right to cause the next wave of outbreaks after XBB.1.16 due to its greater pervasive capacity than existing strains as a result of mutations at F456L, which increase immune evasion (Credit: Rajnarayanan R)

2. Disease control and prevention policies are the basis for fighting epidemics.

UK study results Published in the journal Science on July 20. Analyze the spread of the species. Omicron in the UK

Travel bans from high-infected countries were found to be less effective. If the epidemic in large areas is allowed exponentially and there are no adequate disease control measures.

The results of this study Points out the importance of disease control and prevention policies in the country. Emphasis on regular defensive behavior monitoring and reporting statistics of infection in the country in a transparent, timely manner, including timely decision-making at the policy level Not waiting until the end, spreading around like a lesson we’ve seen from the crisis of different lands. In the past several years

More importantly, it emphasizes that The decision to cut the outbreak cycle in the first wave of Thailand done correctly

While the result of the management of ripple D614G, Alpha/Delta, and Omicron During that later time How is it known? and why

Should live a conscious life Always protect yourself, don’t get infected or get reinfected. It’s the best for each time. severe illness, death, and risk of Long COVID as well

refer

Genomic assessment of invasion dynamics of SARS-CoV-2 Omicron BA.1. Science. 20 July 2023.

2023-07-24 01:08:00

#Mor #Theera #update #COVID19 #strain #EG.5.1 #outbreak #Portugal #Austria

July 24, 2023 0 comments

Technology

Warning! Omicron EG.5 Subspecies: On the Verge of an Epidemic

by Chief editor of world-today-news.com July 23, 2023

written by Chief editor of world-today-news.com

Warning!Omicron The EG.5 subspecies is on the verge of an epidemic. Dr. Teera reveals the latest data from the US CDC, showing a clear increase in the proportion, now more than 11.4% in the US. Japan has a much higher percentage of detections nationwide.

COVID-19 continues to mutate before its origin and continues to spread.

Especially the Omicron species (Omicron), which occupies the largest proportion worldwide.

Most recently, Assoc. Chulalongkorn University Has posted a message via Facebook “Thira Woratanarat (Papa Mee Keen)” with a message indicating the global COVID situation that
Omicron subspecies EG.5 is coming

Dr. Teera said that the latest data from the US CDC until July 22, 2023 indicates that EG.5 has clearly increased in proportion, now about 11.4%.

If you look at the distribution across America, you will find that almost all of them exceed 10%. except the central and southern parts, while the Northeast region is almost 20%

In Japan, data from Honey H. indicated that EG.5.1 occupied a much higher percentage of detections nationwide except for the Miyagi region.

EG.5.x is a successor mutation from the XBB.1.9.2 family, with the key mutation F456L believed to result in higher infectious replication potential.

Dr. Teera said that children with type 1 diabetes had a higher rate.

The study, published in JAMA Network Open, compared rates of type 1 diabetes in children and adolescents under 19 and found that in 2020, when COVID-19 began to spread around the world. There are 14% more children with type 1 diabetes than in the previous year, while in 2021 the incidence rate of type 1 diabetes is even higher, 27% higher than in 2019.

Although more studies are needed to determine if the main cause is directly caused by COVID. how much or will come from behavioral changes of children and adolescents that affect risk factors for disease but at least The rising incidence of the disease is a wake-up call for health systems around the world. including parents Pay attention to the health of children and adolescents as well.

July 23, 2023 0 comments

Health

Update on COVID-19 strains epidemic in America and Metformin for COVID-19 treatment and Long COVID prevention

by Chief editor of world-today-news.com June 10, 2023

written by Chief editor of world-today-news.com

On June 10, 2023 Assoc. Prof. Dr. Thira Worathanarat or “Doctor Thira“Faculty of Medicine Chulalongkorn University Facebook post about the issue “COVID-19“Indicates that update knowledge of COVID-19

COVID-19 strains epidemic in America

Data from the US CDC up to 10 June 2023 assessed that Omicron subspecies XBB.1.5 Still occupying the proportion of the main epidemic at 39.9%, with a continuous downward trend.

while the subspecies XBB.1.16 increased to 18.2%, with a tendency to continue to increase as well

The next one is XBB.1.9.1 at 12.5%.

followed by XBB.1.16.1 and XBB.1.9.2, which were found in the same proportion of 8.4%.

and XBB.2.3, another variant under Monitoring (VUM) that the World Health Organization monitors, was also found at 6%.

the above characteristics Suffice it to point out the trend of species change in America. That should be more similar to Australasia in the coming quarters.

Some scientists, such as Weiland JP, have estimated that this could result in more hospitalizations in the US as well, with increases in 1.16.x, 1.9.x, 2.3.

Metformin for COVID-19 Treatment and Long COVID Prevention

According to research published in the New England Journal of Medicine last year, it reduced the risk of getting sick to the emergency department. hospital stay and death was approximately 42% (confidence range from 6%-65%).

Most recently, research published in The Lancet Infectious Diseases two days ago. Metformin was also studied and found to reduce the viral load in the blood. And most importantly, it can reduce the risk of Long COVID by about 40% by the incidence rate.Long COVID problem At 300 days after infection It was 10.4% in the drug-free group, while 6.3% in the drug-treated group.

If you calculate the Number needed to treat, it will be about 25, meaning that if you use the drug for 25 people, it will reduce the risk of Long COVID for 1 person.

The research above was studied in a population aged 30-85 years who were obese. or overweight Having a body mass index (BMI) of 25 or higher

The dose used is Metformin (500 mg) 1 tablet on the first day, then increased to 1 tablet twice a day. From day 2-5, continue with 1 morning pill and 2 evening pills for 14 days. The drug should be started within 3 days after the onset of illness.

However, the limitation of the above study results is It cannot be used for other populations under 30 years of age, including people with normal body weight. or have a body mass index less than 25

Metformin is now of interest to medical professionals around the world. Because there is standard research data that proves the properties step by step and the price is cheap, although the mechanism explaining the properties is still unclear. But laboratory data suggests that the drug inhibits the replication of the disease virus.COVID-19 which suggests that this mechanism may play a role in reducing the risk of severe illness and reducing the risk of Long COVID

refer

1. Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19. NEJM. 18 August 2022.

2. Outpatient treatment of COVID-19 and incidence of post-COVID-19 condition over 10 months (COVID-OUT): a multicentre, randomised, quadruple-blind, parallel-group, phase 3 trial. The Lancet Infectious Diseases. 8 June 2023.

3. Covid-19: Metformin reduces the risk of developing long term symptoms by 40%, study finds. BMJ. 8 June 2023.

2023-06-10 01:29:00

#Theera #updates #COVID19 #America #strain #XBB.1.5 #decrease

June 10, 2023 0 comments

Health

Updates on COVID-19: Screening in Hospitals, Vaccines for XBB Strains, and Risk Factors for Long COVID

by Chief editor of world-today-news.com June 6, 2023

written by Chief editor of world-today-news.com

Assoc. Prof. Dr. Thira Woratanarat, Faculty of Medicine Chulalongkorn University posted a Facebook stating that it updates knowledge of COVID-19.

1. If the hospital does not screen for COVID-19 In patients who need to go to bed for treatment will increase the rate of infection with COVID-19 more within the hospital (Figure 1).

Research team from Harvard University, USA. The results of the study were published in the medical journal JAMA Internal Medicine on 5 June. This is from a study in the United Kingdom (England and Scotland).

This study reinforces the need for hospitals to prioritize screening in all patients admitted. to reduce the risk to patients themselves surrounding patients and personnel in the hospital because if there is an infection during treatment It will result in more deaths because most patients will have underlying disease. or poor health status Infection can exacerbate the disease and lead to more complications.

2. Vaccines specific to the epidemic strain It will be used in the fall of this year.

Information from CTV News on June 5, 2023 reported that Biontech, Germany. gave the news that Vaccine against COVID-19 Species-specific XBB strains are produced. and applying for certification from relevant agencies This should complete the approval process by the end of the summer. And it will be available in the world’s northern countries in early autumn.

3. Multiple infections: Females and the elderly are at increased risk of Long COVID.

Research by a team from Brazil. Study in a group of 7,051 medical personnel from 2020-2022 published in the medical journal Infection Control & Hospital Epidemiology on June 5, 2023.

The prevalence rate of Long COVID is about 27%.

recurrent infection Reinfections increase the risk of Long COVID by 27%.

Females were 21% more at risk than males.

and aging increases the risk slightly.

If a booster dose of vaccination (from 4 or more doses) can reduce the risk by more than 80%.

…Our Thai situation There are a lot of infections each day, and the morbidity and death statistics tend to increase continuously.

protection against infection or not repeating is the best

avoid crowded places poor ventilation

Beware of being in close contact without protection.

Do not share food and belongings with others outside the home.

If you feel unwell, you should seek treatment immediately. Self-isolate from others for 7-10 days until no symptoms and repeated ATK test results are negative.

wearing a mask correctly It will greatly reduce the risk.

refer
1. Discontinuation of Universal Admission Testing for SARS-CoV-2 and Hospital-Onset COVID-19 Infections in England and Scotland. JAMA Internal Medicine. 5 June 2023.
2. BioNTech proceeding with COVID-19 shot in line with WHO guidance. CTV News. 5 June 2023.
3. Risk factors for long coronavirus disease 2019 (long COVID) among healthcare personnel, Brazil, 2020–2022. Infection Control & Hospital Epidemiology. 5 June 2023.

2023-06-06 08:00:00

#Doctor #Theera #reveals #booster #injections #reduce #risk

June 6, 2023 0 comments

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Doctor Thira

“Mr. Thira” updates the COVID-19 strain EG.5.1, a candidate that may lead to an outbreak at the end of this year. ready to compare the symptoms of COVID-19 various species

Related Content

“Mor Theera” updated COVID-19, the EG.5.1 strain found outbreaks in Portugal about 25%, Austria 17%, and Sweden 13%, increasing in European countries. Just like what we see in Asia and America.

Related Content

Warning!Omicron The EG.5 subspecies is on the verge of an epidemic. Dr. Teera reveals the latest data from the US CDC, showing a clear increase in the proportion, now more than 11.4% in the US. Japan has a much higher percentage of detections nationwide.