Doctor Thira

Assoc. Prof. Dr. Thira Woratanarat, Faculty of Medicine Chulalongkorn University posted on Facebook stating that the performance of BA.2.86

Last night, Peking University’s Cao YL released the results of a laboratory study.

1. BA.2.86 has a very different antigen from other Omicron strains.

2. BA.2.86 is more resistant to immunity than other strains. that are currently spreading both XBB.1.5, EG.5.1 and FL.x

3. BA.2.86 is resistant to all currently approved antibodies.

4. However, if comparing the transmission performance, BA.2.86 has such performance slightly less than XBB.1.5.

From the results of Cao YL’s study, there is academic evidence to support that this omicron substrain BA.2.86 is very different from the previous strain. By being able to dodge immunity greatly. Therefore, there is a chance that people who have previously been infected with other strains will be re-infected. Including people who have immunity from vaccines as well

However, with the ability to infect Since the infectivity is less than that of XBB.1.5, it is likely that BA.2.86 will not spread rapidly. which is not as fast as the Omicron BA.1

must not be careless Assessment of the detection rate of BA.2.86 compared to when Delta (21J) and Omicron BA.2 were reported, BA.2.86 has a faster detection rate (Figure 5: Credit: Fleishon S)

latest situation France has also reported cases of BA.2.86.

Estimated that the wave at the end of this year, EG.5.x, will lead the outbreak, while BA.2.86 will take several months to incubate. which tends to develop further mutations to increase the ability to spread infection However, due to its high immune evasion performance, it is likely to be a successor to EG.5.x.

Should live a conscious life, not careless, always protect yourself.

2023-09-01 02:54:00

#Theera #reveals #BA.2.86 #performance #immune #resistance #strains

Assoc. Prof. Dr. Thira Woratanarat, Faculty of Medicine Chulalongkorn University posted a Facebook stating that it assessed the outbreak situation of BA.2.86 (Pirola).

1. Detection report

Information until this morning Detections have been reported in Israel, Denmark, UK, USA (Michigan and Ohio), Japan (people traveling from Japan to Virginia. United States), South Africa and, most recently, Switzerland. (found in municipal wastewater in the county of Bern, data from Prof.Stadler T) and Thailand (found in municipal wastewater, data from Dr.Wannigama L).

Therefore, such starburst detection global coverage across the Americas, Europe, Asia and Africa

This is mainly due to the large reduction in the number of random species in surveillance systems around the world. The presence of detection reports in many countries and continents in a short period of time. As such, it indicates the possibility that BA.2.86 may spread more than expected. As a result, the World Health Organization lists this strain as Variants under Monitoring and other countries. Keep a close eye on each other. Because it could lead to a serious outbreak like when Omicron appeared after Delta. and cause many infections Including causing a number of sick people and increased deaths

2. Detection period

Reports from countries around the world have been detected since July 2023.

3. origin

undetermined Experts now estimate that this strain may have emerged between May and July 2023, possibly due to mutations in the virus in a chronic infection before infecting others. However, we still have to wait for further proof.

4. Viral Mutation Characteristics

What makes the world very worried is The mutant loci of BA.2.86 are numerous, different from other Omicron strains. Both current and former epidemic BA.2 as well as XBB.1.5 and EG.5.1 (Figure 1, Cr: Topol E, Scripps Research).

However, those mutation positions There are several positions that suggest that the performance of the virus may be improved. both in terms of immune resistance and binding to target cells

The large number of mutant loci of BA.2.86 was therefore assessed. There is a chance that it will be listed as a new strain after Omicron and may need to be upgraded to Variant of Concern (VOC) if it becomes widespread. or make the disease more severe or affect the effectiveness of existing vaccines and drugs However, it is necessary to wait for the results of the next study.

5. Assessment of the impact of the virus BA.2.86

Earlier, the World Health Organization issued a risk assessment report for BA.2.86 stating that it has the potential to cause a global outbreak.

The US CDC released a vulnerability assessment last night, August 23, 2023, stating that BA.2.86 has the potential to cause infection more easily. Both among people who have been infected with COVID-19 before, including people who have been vaccinated.

Information on the severity of the disease is not yet available.

However, if roughly assessed from the location of the virus mutation It is expected that the standard antiretroviral drugs that are available should still be used. However, it is necessary to wait for the results of further clinical studies to see if the actual situation will be as expected or not.

…with the knowledge so far It suggests that BA.2.86 could lead to a global outbreak. Due to the increased performance of the virus from the mutation so much that it is different from the original strain that has spread

Emphasize that we are all aware of the situation.

Should live a conscious life, not careless, always protect yourself.

avoid crowded places poor ventilation

Do not share food with other people outside the home.

wearing a mask correctly It will greatly reduce the risk. no matter what breed

keep in mind that infected each time Risk of getting sick, dying and having Long COVID problems that follow until deteriorating quality of life. and have long-term expenses

Not infected or re-infected It’s the best.

2023-08-24 02:56:00

#Teera #reveals #assessment #epidemic #situation #BA.2.86

Assoc. Prof. Dr. Thira Woratanarat, Faculty of Medicine Chulalongkorn University posted on Facebook stating that BA.2.86 Update

last night Two cases of BA.2.86 have been reported in South Africa. which is a specimen collected since the end of July (24 July 2023)

Makes the total cases now 9 cases from 6 countries (if including Japan In case the report was found in the state of Virginia, America as a person traveling from Japan)

Thus, the distribution of BA.2.86 from various continents over the same period: Asia (Israel, Japan), Europe (Denmark, United Kingdom), America and Africa (South Africa).

And most cases have no travel history. indicated that it was a domestic infection

Emphasizes the trend that BA.2.86 has spread throughout the world. And there are likely to be more people infected now than reported.

Throughout the Omicron outbreak from 2022 to the present Virus mutations are usually gradual, in a step ladder pattern, with few changes in genetic loci. and result in changes in the performance of the virus, such as being more resistant to immunity but in a manner that is still predictable and assessable without seldom changing the violence as followed

But BA.2.86 is different from what it used to be. because there are many mutation positions This makes the virus very different from both the currently spreading strain XBB.x and its direct ancestor BA.2.

It is speculated that BA.2.86 may be caused by a chronic infection that incubates viral transformation. But still can’t confirm where it came from.

It will take another 2 weeks. The results of the evaluation of virus performance from various laboratories. The world will gradually come out to know each other.

Of the BA.2.86 virus mutation loci, there are 16 loci that existing knowledge suggests may lead to increased immune resistance.

With surveillance systems that exist around the world now The number of randomly tested specimens has decreased by 90% compared to when the Omicron outbreak began in early 2021, making it difficult to accurately assess the actual outbreak situation.

Hence, the number of reported cases detected continues to increase in such a short period of time. is therefore an important signal because it indicates the possibility that BA.2.86 will be an important enemy in the near future that could lead to a global outbreak

Should live a conscious life, not careless, always protect yourself.

wearing a mask correctly It will greatly reduce the risk.

2023-08-23 09:57:00

#Mor #Theera #reveals #trend #BA.2.86 #spreading #world #number #infections #expected #higher #reported

Assoc. Prof. Dr. Thira Woratanarat, Faculty of Medicine Chulalongkorn University posted a Facebook stating that it updates the situation of COVID around the world.

EG.5.1 in Japan

A recent report by Japan’s National Institute of Infectious Diseases estimates that EG.5.1 will account for 46% of new cases nationwide by the end of this week.

in Tokyo The detection rate of EG.5.1 doubled in July. Most recently, it is still around 22%, behind XBB.1.16, found at 28%.

The overall number of patients requiring hospitalization nationwide in the week to August 6 reached 11,801.

A new subspecies of BA.2

from tracking the changes in the virus strains Recently, a virus mutated from BA.2 has been detected with more than 30 mutation loci (Figure 1, Credit: Hisner R.).

Currently detected in Israel and Denmark.

must continue to follow that What will be the performance of this new subspecies? And how will this new subspecies be named?

Long COVID and Mitochondria Disorders

After the research team from the United States The results of the study were published in Science Translational Medicine on August 9. by pointing out that COVID-19 infection This causes abnormalities in the Mitochondria, the key components within the body’s cells that produce energy. (Mitochondrial dysfunction) and may be one mechanism to explain the symptoms of Long COVID patients.

Most recently, a team from the US NIH’s National Heart, Lung, and Blood Institute published their findings Aug. 14, 2023, in the journal PNAS Medical Sciences. Mitochondria dysfunction in cells is likely associated with Long COVID.

However, considering the nature of the disease and pathophysiology Such a mechanism may explain Long COVID symptoms such as fatigue/chronic fatigue. Problems with thinking, memory, etc.

Each infection can cause illness, death and risk of Long COVID.

Should live consciously, not carelessly, protect yourself regularly.

travel Plan carefully to reduce the risk of infection, including where to eat, travel, accommodation, and activities.

wearing a mask correctly It will greatly reduce the risk.

Because in the end, when stuck, sick, dead or disabled, those who have to face problems are ourselves and those close to us.

Entering the Liu City No need to blink If it’s not right

The statistical numbers are stuck in sickness, death, and disability, which are seen all over the world. and provable

Health consciousness is important. and determines the path that must be faced

refer
1. New coronavirus variant EG.5 gains momentum in Japan. Japan Times. 14 August 2023.
2. WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome. PNAS. 14 August 2023.

2023-08-15 07:44:00

#Thira #update #COVID #world #reveals #Tokyo #EG.5.1 #July #times #higher