TikTok Trend to Health Trap: Doctors Warn of Risks in Off-label Diabetes Drug Use for Weight Loss
October 28, 2025, 08:11:12 AM EST – A viral TikTok trend promoting the use of diabetes medications Ozempic and Mounjaro for rapid weight loss is prompting urgent warnings from medical professionals, who cite potentially serious health consequences stemming from off-label prescriptions and self-medication. The surge in demand,fueled by social media endorsements,is creating shortages for patients wiht diabetes and raising concerns about the long-term effects of these drugs when used by individuals without a medical need.
Originally designed to manage type 2 diabetes by regulating blood sugar, semaglutide (Ozempic) and tirzepatide (Mounjaro) have gained notoriety for their appetite-suppressing side effects, leading to significant weight loss in some users. While the FDA has approved semaglutide under the brand name Wegovy specifically for weight management in individuals with obesity or weight-related medical conditions, its use for cosmetic weight loss-particularly without medical supervision-is driving a perilous trend. Doctors report a growing number of patients experiencing severe nausea, vomiting, diarrhea, and, in rare cases, pancreatitis and intestinal blockages.
The American Society of Metabolic and Bariatric Surgery (ASMBS) estimates that demand for these medications has increased by over 300% in recent months, largely attributed to social media influence. “We’re seeing a significant diversion of these medications, with people obtaining them through questionable sources or pressuring doctors to prescribe them off-label,” stated Dr.Amanda Velazquez, President of ASMBS, in a recent press conference. ”This isn’t a harmless shortcut to weight loss; it’s a potentially dangerous gamble with your health.”
The medications work by mimicking a natural hormone that regulates appetite and blood sugar, but their long-term effects on individuals without diabetes are largely unknown. Experts caution that prolonged use can lead to nutrient deficiencies, muscle loss, and potentially even cardiovascular problems. Furthermore, the sudden discontinuation of these drugs can result in rapid weight regain and other adverse effects.
Authorities are investigating reports of compounded versions of semaglutide and tirzepatide circulating online, which may contain incorrect dosages or harmful impurities. The FDA has issued warnings against purchasing medications from unregulated sources and urges individuals to consult with a healthcare professional before considering any weight loss drug.The situation is evolving, with ongoing research aimed at better understanding the risks and benefits of these medications, and increased scrutiny of online platforms promoting their off-label use.
