Fungus From Ancient Tombs Shows Promise in Fighting Cancer

Scientists have discovered that a fungus, historically linked to the deaths of archaeologists, may hold the key to new cancer treatments. Research indicates molecules derived from this fungus could potentially disrupt the growth of leukemia cells, offering a new avenue in the fight against cancer.

Unearthing a Potential Cure

The fungus, *Aspergillus flavus*, often called the “mummy’s curse,” is being studied for its potential in combating cancer. A recent study from the University of Pennsylvania revealed promising results in stopping leukemia. The team, led by Dr. Sherry Gao, isolated and purified asperigimycins, a novel class of molecules from the fungus.

The molecules, developed inside the fungus and subsequently modified by the study authors, work by interfering with cell division. This process is key to halting the uncontrolled cell growth that defines cancer.

“Fungi gave us penicillin,”

—Dr. Sherry Gao, Associate Professor at Penn

The researchers tested these molecules against common cancer cells. Some displayed “potent” effects, even without modification, against leukemia cells. A modified variation performed as well as existing FDA-approved leukemia drugs.

How it Works

The team’s work focuses on a class of peptides often studied in bacteria, marking a unique approach to fungal research. The scientists believe these molecules block the formation of microtubules, which are vital for cell division.

“Cancer cells divide uncontrollably,” Dr. Gao stated, “These compounds block the formation of microtubules, which are essential for cell division.”

Challenges and Implications

*Aspergillus flavus* is a frequently isolated mold species in agriculture and medicine and can cause lung infections in people, particularly those with weakened immune systems. This is especially true for those with compromised immune systems, according to the CDC, with about 200,000 cases annually (CDC 2024).

The team, which includes researchers from several universities, hopes to continue its work with animal models and eventually human trials. The research was financed by the National Institutes of Health.

These findings open up new possibilities for cancer treatments, potentially providing a new generation of drugs based on naturally occurring compounds. Further research will reveal the full extent of its potential.