Publisher Correction Issued for Landmark Study Revealing Neuron–Cancer Dialog
A recent Publisher Correction has been issued regarding the Cancer Cell article “Functional synapses between neurons and small cell lung cancer” (published online February 16, 2024), detailing a groundbreaking discovery of direct communication between neurons and small cell lung cancer (SCLC) cells via functional synapses. The correction, published March 11, 2024, addresses minor clarifications regarding author affiliations and does not alter the core findings of the research.
The original study, led by researchers from the University of Cologne and LMU Munich, demonstrated that SCLC cells form synapses – structures typically used for neuron-to-neuron communication – with neurons in the peripheral nervous system. This neuronal-cancer interaction was shown to promote SCLC growth and metastasis.
Key researchers involved in the study include Marcel Schmiel, Reinhard Büttner, and Roman K. Thomas (University of Cologne); Thorsten Persigehl & Holger Grüll (Institute for Diagnostic and Interventional radiology, University Hospital Cologne); Martin L. Sos (Department of Translational Oncology, German Cancer Consortium (DKTK), Munich & Department of Medicine III, LMU University Hospital Munich); Guido Reifenberger (institute of Neuropathology, Heinrich Heine University Düsseldorf); MAX AFPLOGZ (Institute of Anatomy II, Heinrich Heine University Düsseldorf); Silvio O. Rizzoli (University Medical Center Göttingen & Cluster of Excellence ‘multiscale Bioimaging’, University of Göttingen); Matteo Bergami (Institute of Genetics & faculty of Medicine, University of Cologne); and Hans Christian Reinhardt (West German Cancer Center, University Hospital Essen, & DKTK, University Hospital Essen & Center for Molecular Biotechnology, University Hospital Essen).
The findings challenge conventional understanding of cancer progression and open new avenues for therapeutic intervention, potentially by disrupting these neuronal-cancer synapses. The Publisher Correction ensures the accuracy of author affiliations associated with this pivotal research.