Childhood Health May Predict Adult Male Disease Risk
Early infections, weight impact later insulin-like peptide 3 levels
New research reveals that boys who are overweight early in life or contract infectious diseases as infants may face an elevated risk of developing chronic conditions later. Monitoring childhood health could offer a way to predict and prevent future health issues.
Key Development
Scientists at the University of Nottingham analyzed insulin-like peptide 3 (INSL3) levels—a unique testis hormone biomarker—in 24-year-old men, relating these levels to childhood health and lifestyle factors. Prior work by the team indicated that INSL3 levels in younger men could predict chronic diseases later in life.
The recent study, featured in Andrology, demonstrated that being overweight during childhood or adolescence, along with experiencing chickenpox or other infectious diseases in infancy, significantly lowered adult INSL3 levels by 10 to 15%. A reduction may increase the risk of conditions like diabetes, cardiovascular disease, bone weakness, or sexual dysfunction.
“We know that INSL3 hormone levels in boys and men are a robust biomarker of the testicular capacity to produce the steroid hormone testosterone that is essential not only for reproduction but also for overall healthy well-being. In this new study we have found that there is a clear link between certain health factors in childhood at a time before puberty when the testes are still developing and later men’s health as they age.”
—Dr. Ravinder Anand-Ivell, Associate Professor in Endocrinology and Reproductive Physiology, University of Nottingham
Study Details
Researchers examined data from the “Children of the Nineties” cohort (Avon Longitudinal Study of Parents and Children) from the University of Bristol. The team correlated INSL3 levels in these young men with clinical and lifestyle factors from their childhoods to identify elements impacting men’s health as they age. Importantly, the study also pinpointed factors of lesser significance.
For instance, the CDC reports that childhood obesity affects over 14.7 million children and adolescents in the United States (CDC, 2024), highlighting the scale of the risk factor identified in the new study.
Predictive Biomarker
Dr. Anand-Ivell emphasizes the importance of early vaccination and adds that the biomarker INSL3 and childhood health data may help to predict at-risk men. Preventative measures can then be considered before diseases develop. The next research phase involves creating a high-throughput assay for routine INSL3 measurement in clinical assessments of male healthy aging.
The research indicated that childhood overweight status or early infancy infectious diseases, like chickenpox, markedly increased the risks to men’s future health, reinforcing the significance of early vaccinations.