Cancer Network Foundation joins hands with hematology specialists and the MPN Patients Club Organize an online discussion to provide knowledge on Blood Cancer Month I hope Thai people understand. Be aware of chronic abnormal bone marrow production of blood cells.
Cancer Network Foundation joins hands with hematology specialists and the MPN Patients Club Organize an online discussion to provide knowledge on Blood Cancer Month I hope Thai people understand. Be aware of chronic abnormal bone marrow production of blood cells.
Cancer Network Foundation for Cancer Patients Together with hematology specialists MPN & MDS Working group and the MPN Leukemia Patients Club of Thailand. Organize online seminars for patients Caregivers and the public on September 9th, on the occasion of Blood Cancer Awareness Month, on the topic “Be aware of chronic abnormal bone marrow production of blood cells. Blood cancers, MPNs and MDS.”
Asst. Prof. Dr. Noppadol Sirithanaratanakul The chairman of the MPN & MDS Working group of hematology experts discussed the current problem of blood cancer in Thailand, which is increasingly found in patients aged 60 years and over, leading to the organization of a seminar to provide knowledge about Disease and treatment guidelines Including listening to the exchange of direct experiences from patients in taking care of themselves. To be useful for understanding for patients Caregivers and interested citizens
Ms. Sirinthip Khattiyakarn President of the Cancer Network Foundation Recognizing the importance of providing knowledge about cancer and blood diseases in order to be aware of the disease Know how to treat and know how to deal with this disease in maintaining health and living in daily life You can listen to previous episodes on the Facebook page of the Cancer Network Foundation. And read more information on the website of the Cancer Network Foundation.
side Assoc. Prof. Dr. Nonglak Kanitsap Mentioning blood cancer Caused by a chronic condition of the bone marrow making abnormal blood cells. which is the MPN group of blood cancers (Myelofibrosis Neoplasm, MPNs) Most have increased blood cells, divided into 3 common types: thick blood disease, high platelet disease. Bone marrow fibrosis Patients therefore have common symptoms: fatigue, tiredness, easy fatigue, dizziness, and headaches. Some people have skin symptoms, burning pain in the hands and feet, red marks, itching, flushing of the face. This occurs in patients with blood thickening and high platelet ailments. Some people experience abdominal distension. A lump can be felt under the ribcage due to an enlarged spleen, fever due to fibrosis in the bone marrow causing abnormal blood cells to form. Some people have important complications. Blood clots occur in the blood vessels. If it is very severe, the heart muscle may lack blood supply. But MDS bone marrow degeneration (Myelodysplastic Syndromes, MDS) Most people have decreased blood cells. As a result, the patient has symptoms of paleness, anemia, and easy bleeding. The cause of the disease is not clear. May be related to exposure to chemicals or radioactive substances This group of diseases is not contagious. The patients in the MPNs group have a JAK2 mutation.
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In the initial diagnosis of both MPN and MDS, the doctor will take the patient’s history. Check your body to see if you have symptoms of an enlarged spleen. Send for a complete blood count (Complete Blood Count, CBC) to look for abnormalities in blood cell components. By counting the number of red blood cells Look at the blood concentration. white blood cell count and platelet count and additional diagnostic testing by bone marrow aspiration
Treating MPNs by giving antiplatelet drugs such as aspirin, drawing blood (in the case of thick blood), giving chemotherapy or drugs that target JAK2 inhibitors, and giving medicines to reduce the amount of blood cells. Bone marrow transplant is only available in severe cases. Your doctor will monitor your symptoms with periodic blood tests. To assess symptoms, complications and changes and provide appropriate treatment according to symptoms Symptoms of thrombocytopenia and thrombocytopenia, if they become more severe, may change to bone marrow fibrosis or acute leukemia. Therefore, you should check with your doctor regularly.
Assoc. Prof. Dr. Nonglak Kanitsap
Assoc. Prof. Dr. Chantana Phonprasert Describes the degenerative bone marrow disease MDS. (Myelodysplastic Syndromes, MDS) is a disease caused by abnormalities of stem cells in the bone marrow. Causes abnormal blood cell formation Have a shorter lifespan than normal and abnormally shaped blood cells If there are few red blood cells, you will feel pale and tired. If you have low platelets, you will bleed easily. There are spots of blood all over the body and arms and legs. May have low white blood cells, making it easy to get infected If the condition is severe, it may progress to acute leukemia. Found that the cause of MDS disease It is caused by a genetic mutation that occurs later. not born from birth Part of the cause is exposure to carcinogenic chemicals, the benzene group. Heavy metals from industrial plants, smoking, receiving chemotherapy or radiation to treat other cancer diseases Exposure to radioactive substances can cause gene mutations and MDS. in diagnosing disease The doctor will take your history and look at blood test results. Congenital diseases and the use of certain medications that can cause low blood cells without having MDS Certain herbal medicines that are used continuously for a long time can cause low platelets or white blood cells. Complete blood count (CBC), liver and kidney function tests Bone marrow examination Testing for chromosomal abnormalities, such as the absence of chromosomes 5 or 7. Testing for gene mutations found in approximately 90% of cases. A clear diagnosis and classification of disease severity must be assessed. to plan appropriate treatment
Most MDS patients are pale. Treatment can be done by giving injections to stimulate red blood cells. Gives good results in the case of hormones erythropoietin less than 500 U/L. Other treatments such as treatment for genetic abnormalities. and giving blood In the group of patients with low platelets, treatment is given with platelet stimulating drugs only in cases of bleeding and very low platelets. As for the group of patients with low white blood cells Treated with white blood cell stimulating drugs only in cases of frequent infections. For those at high risk who have a chance of turning into acute leukemia. Bone marrow transplantation should be considered in patients under 65 years of age and in good health. There is also treatment using chemotherapy, blood transfusions, and treatment in new drug research projects.
Assoc. Prof. Dr. Chantana Phonprasert
Dr. Sunisa Kongkiatkamon Chulalongkorn Hospital, Thai Red Cross Society, said that due to chronic bone marrow abnormalities, patients can have a good quality of life and live for more than ten years. Therefore, the quality of life of patients with both MPN and MDS is important in disease treatment. The patient may help monitor symptoms and treatment results on their own. In MPN disease, it includes blood thickening disease, high platelet disease. and bone marrow fibrosis. It was found that the 10 most common symptoms in MPN include weight loss, night sweats. Bone pain all over the body Chronic low-grade fever caused by inflammation, itching, lethargy, fatigue, and lack of concentration at work. Full quickly and stomach full especially Bone marrow fibrosis Although this group of patients is found least frequently, there are 10 such symptoms most often. It is more violent than other types. Patients observe symptoms using the MPN10 assessment form, which can be downloaded from the website of the Cancer Network Foundation. Compare the symptoms before diagnosis with after diagnosis to see how much the symptoms interfere with daily life. It is recommended to evaluate every 6 months to monitor symptoms after treatment. If there is a marked increase in symptoms, you should notify the attending physician to check further blood results.
As for MDS disease There is no specific evaluation form yet. But observe the symptoms before and after treatment to see if the results improve or not. will make the doctor in charge Better follow-up of treatment results By observing the symptoms, there is anemia, often symptoms of fatigue affecting daily life. In doing various activities, better or worse? As for symptoms of low white blood cells If you have a fever, you may easily become infected. This may be caused by complications from treatment. or the disease can progress forward You should have a thermometer and record yourself at home. As for symptoms of low platelets, look for red, bleeding spots on the skin. If you experience these symptoms, you must inform your doctor.
Dr. Sunisa concluded by saying that In conclusion, blood cancers can lead to a good quality of life if treated promptly with a hematology specialist. and always take care and observe your own symptoms after Appropriate treatment can increase survival rates.
Dr. Sunisa Kongkiatkamon
(You can watch a replay of the seminar. here)
2023-09-27 14:30:00
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