Scientists Identify Pain Receptor, Paving Way for Healing-Friendly Pain Relief
FLORENCE, ITALY – researchers have pinpointed a specific receptor responsible for pain signaling without hindering the body’s natural inflammatory response, offering a potential breakthrough in pain management and a path away from the side effects of conventional painkillers. The discovery,led by scientists at the University of Florence and NYU College of Dentistry,focuses on the EP2 receptor within Schwann cells – nerve cells crucial in conditions like migraine and arthritis.
For decades, nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen have been relied upon for pain relief, with over 30 billion doses consumed annually in the US alone. Though, long-term use carries notable risks, including stomach damage, bleeding, and potential heart, kidney, and liver problems. These drugs work by suppressing prostaglandin production, which reduces both inflammation and pain.
“Inhibition of inflammation can actually slow down recovery,” explained Professor Piaranglo Geppetti of the University of Florence. “A better strategy is to only target pain, without disturbing the benefits of inflammation.”
The research team discovered that blocking the EP2 receptor locally in Schwann cells eliminated pain in experimental animals while allowing inflammation to proceed normally. This “separation” of pain and inflammation represents a significant advancement.
“Disabling EP2 receptors in Schwann cells really removes pain due to prostaglandins, without affecting inflammation. This is an crucial breakthrough,” Geppetti stated.
Nigel Bunnett, a professor at NYU College of Dentistry, emphasized the importance of inflammation itself, stating, “inflammation, which actually helps recovery, is an important step.”
Scientists are now working to develop drugs specifically targeting EP2 receptors, with potential applications for conditions like arthritis and migraine.While still in the pre-clinical stage, the research offers hope for a new generation of painkillers that could control pain without the severe side effects associated with NSAIDs.
