Aston University Receives Funding to Research Rare Muscle-Wasting Condition
Muscular Dystrophy UK has awarded £140,944 to Dr. Rebecca Jones at aston University to investigate the causes of inclusion body myopathy,also known as VCP multisystem proteinopathy type 1 (VCP MSP-1).This marks the first time the charity has funded research at Aston University and specifically into this condition.
VCP MSP-1 is a rare and frequently enough undiagnosed muscle-wasting condition impacting muscles, bones, and nerve cells. Symptoms are variable but commonly include muscle weakness,bone disease,and memory impairment.Currently, there are no effective treatments, and the underlying mechanisms driving the disease and symptom variation remain unclear.
Dr. jones, a lecturer in the school of Biosciences, will lead a four-year project examining how alterations in the VCP protein contribute to muscle weakness in individuals with VCP MSP-1. The research will focus on the impact of these changes on muscle repair processes, muscle cell structure, and muscle fiber formation.
The goal of the project is to identify potential targets for slowing or halting the progression of the disease, ultimately paving the way for targeted therapies.
This project is one of 13 new research initiatives funded by Muscular Dystrophy UK across England and Northern Ireland, representing a total investment of £2 million. Kate Adcock, Director of Research and Innovation at Muscular Dystrophy UK, stated the funding reflects the charity’s commitment to expanding research into rare conditions and supporting emerging researchers like Dr. Jones and her PhD student.
Alongside Dr. Jones’ work, Professor Jordi Diaz-Manera at Newcastle University is also conducting research into inclusion body myopathy. With this latest investment, muscular Dystrophy UK’s total research commitment now approaches £10 million, supporting 51 active projects across over 25 conditions. The charity is expanding its research portfolio to include projects at institutions in Belfast, london, Nottingham, Oxford, and Portsmouth, aiming to reach more individuals and communities affected by muscle-wasting and weakening conditions.
