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How falling vaccination rates are fueling the antibiotic resistance crisis

Declining Vaccinations Fuel Antibiotic Resistance Crisis

Resurgent Measles Drives Secondary Bacterial Infections, Increasing Drug Use

Falling vaccination rates are exacerbating the global antibiotic resistance crisis, a threat often overshadowed by antibiotic overuse. The resurgence of preventable diseases like measles, linked directly to lower immunization coverage, is creating a cascade effect that intensifies the need for antibiotics.

Measles Outbreaks Strain Healthcare Systems

Canada is experiencing a significant comeback of measles, a disease previously eliminated. In early 2025, Ontario alone recorded 2,200 cases by mid-July, with the majority affecting unvaccinated individuals. Similarly, an Alberta outbreak beginning in March had surpassed 1,300 cases by mid-July, outstripping the entire U.S. case count for the same period.

Measles, declared eliminated in Canada in 1998, is reappearing due to missed or delayed immunizations. While seemingly localized viral outbreaks, they trigger widespread consequences, including increased illness, severe complications, and consequently, a greater demand for antibiotic treatments.

Viral Weakness Creates Bacterial Opportunity

Although antibiotics do not combat viral infections like measles, the virus severely compromises the immune system. This weakened state leaves individuals highly susceptible to secondary bacterial infections, such as pneumonia and ear infections, which require antibiotic intervention.

A 2019 study published in *Pediatrics* highlighted this pattern, revealing that a substantial number of children hospitalized with measles in the U.S. developed secondary bacterial infections, necessitating antibiotic therapy. Experts anticipate similar trends emerging from the current Ontario outbreak as data is analyzed.

The World Health Organization reported a 75% increase in measles outbreaks globally between 2021 and 2022, underscoring a worldwide trend of waning vaccine-induced immunity and rising susceptibility to preventable diseases (WHO, 2023).

The rise in infectious diseases like measles is indirectly fueling the antibiotic resistance crisis.

This connection between declining vaccination and increased antibiotic use is a critical, yet often under-discussed, driver of antibiotic resistance. Addressing immunization gaps is paramount to mitigating this multifaceted public health challenge.

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