what are GLP-1 drugs and how do they work?

GLP-1 drugs, or glucagon-like peptide-1 receptor agonists, are a class of medications used to manage type-2 diabetes and obesity. They mimic naturally-occurring gut hormones called incretins,improving insulin secretion,inhibiting glucagon secretion,slowing stomach emptying,and reducing appetite.

How effective are GLP-1 medications for weight loss?

Semaglutide and tirzepatide, both GLP-1 drugs, have demonstrated importent weight loss results.Semaglutide leads to an average weight loss of 15%,while tirzepatide can result in up to 20% weight loss,comparable to bariatric surgery outcomes.

What other health benefits do GLP-1 drugs offer?

Beyond weight loss, GLP-1 drugs have shown potential in reducing cardiovascular events, improving liver health (reducing fatty buildup and fibrosis), and even showing promise in lowering the risk of Alzheimer's and dementia. They may also reduce cravings and help with alcohol addiction.

What is the history behind the development of GLP-1 drugs?

The study of incretins, gut hormones that regulate insulin and glucose, began in the early 20th century. GLP-1, the first incretin, was discovered in 1986. Novo Nordisk played a crucial role in developing stable GLP-1 medicines, leading to the creation of liraglutide and later, the more effective semaglutide.

Are ther any new GLP-1 drugs in development?

yes, several new GLP-1 drugs are currently in the pipeline. These include drugs with less frequent dosing schedules (once-a-month) and oral pills. Examples include retatrutide, CagriSema, orforglipron, danulipron, Survodutide, and Mazdutide, all in various stages of clinical trials.

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GLP-1 Drugs & Obesity: A Treatment Revolution Explained

by Dr. Michael Lee – Health Editor June 29, 2025

written by Dr. Michael Lee – Health Editor June 29, 2025

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GLP-1 Drugs Revolutionize Weight Loss and Offer Additional Health Benefits

the landscape of weight management and diabetes treatment is undergoing a significant change with the advent of GLP-1 drugs. Pharmaceutical companies are racing to innovate within the GLP-1 receptor agonist class,with Novo Nordisk recently launching its injectable semaglutide in India,following Eli Lilly‘s tirzepatide. These medications, initially designed for type 2 diabetes, have demonstrated remarkable efficacy in promoting weight loss and are being investigated for a range of other health conditions.

Understanding GLP-1 Receptor Agonists

GLP-1 drugs, short for glucagon-like peptide-1 receptor agonists, represent a novel class of medications primarily prescribed for managing type 2 diabetes and obesity. these drugs function by mimicking incretins, naturally occurring gut hormones, with GLP-1 being

Dr. Michael Lee – Health Editor

Dr. Michael Lee – Health Editor Dr. Michael Lee is a physician, medical writer, and Health Editor for World Today News. He translates complex health topics into clear, practical advice and leads our coverage of medical breakthroughs, public health, and wellness.

GLP-1 Drugs & Obesity: A Treatment Revolution Explained

GLP-1 Drugs Revolutionize Weight Loss and Offer Additional Health Benefits

Understanding GLP-1 Receptor Agonists

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