Gene Discovery Offers New Hope for Cancer Therapy and Precision Medicine
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A groundbreaking study published in frontiers in Endocrinology has identified a gene, SDR42E1, as crucial for vitamin D absorption and metabolism. This discovery holds significant promise for precision medicine,including potential applications in cancer treatment.
Evergreen Insights
Vitamin D is more than just an essential nutrient; it acts as a precursor to calcitriol, a vital hormone. Calcitriol plays a critical role in regulating calcium and phosphate absorption in teh intestines, which is fundamental for bone health. Furthermore, it influences cellular growth, muscle function, nerve cell activity, and the immune system.
Dr. Georges Nemer, an associate professor at Hamad Bin Khalifa University in Qatar and the study’s lead author, stated, “We show that the blocking or inhibition of the SDR42E1 gene can selectively stop the growth of cancer cells.”
The research team was motivated by prior findings linking a specific mutation in the SDR42E1 gene on chromosome 16 to vitamin D deficiency. This mutation leads to a premature, inactive form of the gene.
Utilizing CRISPR/CAS9 genetic editing, researchers inactivated the SDR42E1 gene in a colorectal cancer cell line, HCT116. Thes cells typically exhibit high SDR42E1 expression, indicating its importance for their survival. Following the introduction of the defective gene, cancer cell viability decreased by 53%. The study also revealed that the expression levels of 4,663 “downstream” genes were altered, highlighting SDR42E1’s role as a key molecular switch in numerous cellular health processes.
Many of these affected genes are involved in cancer-related cellular signaling and the absorption and metabolism of cholesterol-like molecules. These findings suggest that inhibiting SDR42E1 could selectively eliminate cancer cells while sparing healthy neighboring cells.
“Our results open new directions in precision oncology, although clinical transposition requires rigorous validation and long-term development,” commented dr. nafiz Hendi, a professor at middle East University in Jordan and a co-lead author of the study.
Beyond its potential in cancer therapy, the research indicates that SDR42E1 has a dual function.Artificially increasing its levels in specific tissues through genetic technology could also be beneficial,leveraging the known positive effects of calcitriol.
Frequently Asked Questions
What is the significance of the SDR42E1 gene?
The SDR42E1 gene is essential for the intestinal absorption and metabolism of vitamin D.
How might this discovery impact cancer treatment?
Inhibiting the SDR42E1 gene has shown the potential to selectively stop the growth of cancer cells.
What technology was used in the study?
The researchers used CRISPR/CAS9 genetic editing to modify the SDR42E1 gene.
What are the broader implications of this research?
The findings suggest new avenues for precision medicine and oncology, and potentially for enhancing the benefits of vitamin D through genetic manipulation.
Compliance & Disclaimers
This article provides information on scientific research and potential medical applications. It does not constitute health, financial, or legal advice. Consult with qualified professionals for any personal health or financial concerns.
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