Vericiguat Shows Consistent Benefit for Heart Failure Patients in New Analysis
MADRID, SPAIN – August 30, 2025 – A pooled analysis of data presented today at the European Society of Cardiology (ESC) Congress 2025 reinforces the benefits of vericiguat, a soluble guanylate cyclase (sGC) stimulator, for a wide spectrum of patients with heart failure and reduced ejection fraction (hfref). The findings, unveiled during the HOT LINE 2 session in Madrid, demonstrate consistent improvements in clinical outcomes nonetheless of baseline characteristics, offering potential for broader request of the therapy.
The analysis combines results from the pivotal VICTOR and VICTORIA clinical trials, providing a more comprehensive understanding of vericiguat’s efficacy. Heart failure affects millions worldwide, and despite advances in treatment, important unmet needs remain, particularly for patients who don’t respond optimally to existing therapies.This data suggests vericiguat can provide additional benefit across diverse patient populations, possibly reducing hospitalizations and improving quality of life. Further research will focus on identifying specific patient subgroups who may benefit most from vericiguat.
Researchers presented findings from ‘VICTOR: Vericiguat Global Study in Participants with Chronic Heart Failure’ and ‘VICTORIA: Vericiguat Global Study in subjects with Heart Failure with Reduced Ejection Fraction’ between 08:33 and 08:53 in the Main Auditorium. Previous research, including a 2020 New England Journal of Medicine publication by Armstrong PW, et al., initially demonstrated vericiguat’s positive impact on cardiovascular outcomes in HFrEF patients. A subsequent study by Ezekowitz JA, et al.,published in JACC Heart Fail in 2020,further explored the relationship between N-terminal pro-B-type natriuretic peptide levels and vericiguat’s effects.
The ESC Congress 2025,the world’s largest gathering of cardiovascular professionals,runs from August 29 to September 1,2025,in Madrid and online. More details is available at https://www.escardio.org/Congresses-&-Events/ESC-Congress and https://esc365.escardio.org/ESC-Congress/schedule.
