Shared Brain Signature Uncovered in Diverse Autism Forms

Groundbreaking research reveals a common neural pattern across different genetic forms of autism. This discovery could lead to better understanding and treatment strategies by pinpointing shared brain activity despite varying genetic origins.

Unified Brain Activity

A new study from the **University of Minnesota Medical School** has found that various genetic forms of autism share similar brain activity patterns. Scientists utilized brain-wide recordings from preclinical models. These autism-linked mutations influence how expectations shift during decision-making. The findings were recently published in Nature Neuroscience.

Sensory Processing Differences

The research team discovered that preclinical models with autism-linked genetic mutations struggled to modify their expectations based on new information during decision-making. Unlike typical models, these relied on the frontal brain region and less on sensory areas.

“We hope this research will serve as a stepping stone linking genetic differences and behavioral atypicalities,”

—Jean-Paul Noel, PhD, Assistant Professor

In 2024, the CDC estimated that 1 in 36 children are diagnosed with autism spectrum disorder (CDC). This underscores the need for continued research into the condition.

Examining Neural Responses

Using brain-recording technology, researchers examined entire brains to find common neural responses in different genetic forms of autism. They found a unique brain signature, even with genetic variances. The study suggests that autism models focus more on long-term expectation differences.

This research may open new paths for more targeted autism research, bridging genetic differences and behavioral traits.