cannabis Use Associated with Detectable Alterations to DNA, New Research Reveals
CHICAGO – A new study published in Molecular Psychiatry has revealed a link between cannabis use and measurable epigenetic changes in human blood samples, potentially offering insights into the long-term health effects of marijuana. Researchers at Northwestern University discovered these alterations, which affect how genes are expressed without changing the underlying DNA sequence itself, in individuals who reported cannabis use.
While the study doesn’t establish a causal relationship between cannabis and health problems, the findings represent a meaningful step toward understanding the biological impact of marijuana on the human body. Epigenetic changes have been implicated in a range of conditions, including schizophrenia, bipolar disorder, and substance use disorders. This research, conducted by epidemiologist Drew Nannini and his team, could pave the way for further investigation into the potential long-term consequences of cannabis consumption, especially as legalization expands and usage rates increase.
The research team analyzed data from over 360 individuals, comparing epigenetic markers in those who reported using cannabis with those who did not.They identified specific DNA methylation patterns – a key epigenetic mechanism – that differed significantly between the two groups. “This research has provided novel insights into the association between marijuana use and epigenetic factors,” Nannini said.
Researchers emphasize the need for further studies to confirm these findings across diverse populations and to determine whether these epigenetic changes correlate with specific health outcomes over time. Investigations into the effects of marijuana on age-related health are also planned, aiming to clarify the long-term impact of cannabis on overall well-being. The study was originally published in july 2023 and builds on a growing body of research exploring the complex relationship between cannabis and human health.
