Bubonic Plague Treatment Breakthrough: Oral Antibiotics Show Promise in Madagascar Trial
A prosperous first clinical trial in Madagascar offers a glimmer of hope in the fight against the bubonic plague,a disease with a terrifying history. The trial, led by researchers from Oxford University and Malagasy health services, provides the first concrete evidence of the effectiveness and safety of two treatment approaches.
The study indicates that a 10-day course of oral antibiotics presents a highly effective and safe alternative to the current standard of care – hospitalization and intravenous antibiotic administration. This is a important development, particularly for regions with limited healthcare resources.
Madagascar bears a disproportionate burden of bubonic plague, accounting for approximately 80% of global cases. This deadly disease has a mortality rate ranging from 15% to 25%. The new treatment strategies demonstrated a success rate of around 90%, reducing mortality to approximately 4% of cases.
The clinical trial involved 450 participants suspected of having the plague, with 222 confirmed infections. Participants were randomly assigned to receive either a 10-day course of oral antibiotics or a three-day course of injections followed by seven days of oral antibiotics.
Experts highlight the benefits of oral-only treatment, noting its potential to reduce hospital bed occupancy and minimize hospital-acquired complications like bedsores. Furthermore, this approach is considerably more affordable, a crucial advantage in a country like Madagascar where healthcare access is limited.
Affordable and Accessible Care
This clinical trial marks the first time human trials have been conducted, moving beyond animal studies and safety data. Professor Piero olliaro, the study’s lead author, stated, “Despite its long and deadly history, we had limited clinical data on the treatment of bubonic plague – until now. Thanks to the patients and health workers who participated in the clinical trial, we now have real evidence of an effective and safe treatment.”
He added that further data analysis will enhance understanding of the disease, including identifying risk factors, symptoms, and improving diagnostic accuracy.
Researchers are collaborating with the World Health Association to translate these findings into improved medical practices and ultimately,save lives.The goal is to provide the necessary information to implement these effective treatments globally.
