Cardinals, Saints Open Season as Underdogs in Week 1 Matchup
GLENDALE, AZ – August 31, 2025 – The Arizona Cardinals and New Orleans Saints will kick off their 2025 NFL seasons this Sunday, September 7th, with both teams entering the contest as betting underdogs. Early odds place the Saints as 3.5-point favorites, with an over/under of 41.5 points, according too major sportsbooks.
This season-opening clash carries significant weight for both franchises. Arizona, under new leadership, aims to demonstrate immediate progress after a challenging 2024 campaign.For New Orleans, a strong start is crucial as thay navigate a competitive NFC South division and strive for a playoff berth. The outcome of this game will not only set the tone for each team’s season but also provide valuable insights into their respective strengths and weaknesses.
Currently, the Saints boast a roster featuring several highly-compensated players. As of April 10,2025,New Orleans’ roster includes wide receiver Chris Olave,the team’s highest-paid player at an average annual value of $26.4 million. The Cardinals, simultaneously occurring, are building around young talent and have invested heavily in their defensive line, with edge rusher Zaven Collins ranking among the league’s highest-paid at his position, earning $23 million annually.
Betting lines as of August 31, 2025, show the Saints with a moneyline of -175, while the Cardinals are at +145. The point spread is Saints -3.5 (-110) and Cardinals +3.5 (-110).
Fans can catch the game on FOX at 3:25 PM MST.
