Potential Link Found Between Obesity, Choline Levels, and Accelerated Brain Aging
TEMPE, AZ – November 25, 2025 – New research from Arizona State University suggests a surprising connection between obesity, choline intake, and brain health, perhaps offering insights into Alzheimer’s disease risk. While the study doesn’t establish a direct cause-and-effect relationship, findings indicate that adequate choline levels and good metabolic health in young adults may contribute to neuronal health and healthy aging.
The research, published in Aging and Disease, highlights the complex interplay of factors involved in neurodegeneration. Scientists are increasingly recognizing that brain aging and dementia are not caused by a single factor, but rather a combination of variables.
“Our results suggest that, in young adults, good metabolic health and adequate choline contribute to neuronal health, laying the groundwork for healthy aging,” explains ASU behavioral neuroscientist Jessica Judd.
Researchers suggest low choline levels could be an early warning sign for diseases like Alzheimer’s, and increasing choline intake may have preventative benefits. The liver does produce some choline, but dietary sources are crucial to meeting daily recommended intake. Foods rich in choline include eggs, fish, poultry, beans, and cruciferous vegetables like broccoli.
“Most people don’t realize they aren’t getting enough choline,” says ASU biochemist Wendy Winslow. “Adding choline-rich foods to your routine can help reduce inflammation and support both your body and brain as you age.”
The study builds on existing research exploring the link between obesity and Alzheimer’s risk, and adds choline to the equation as a potentially significant factor. Further investigation is needed to fully understand the three-way relationship and its implications for preventative strategies.
